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腫瘍マウスモデルにおいてプロリル水酸化酵素阻害剤による腫瘍血管の正常化は化学療法に対する感受性を回復させた
https://repository.lib.tottori-u.ac.jp/records/5850
https://repository.lib.tottori-u.ac.jp/records/58508bf28b79-c79f-483f-8b03-f6b2f6f34658
| 名前 / ファイル | ライセンス | アクション |
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本文 : Full Text (706.4 kB)
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要旨 : Summary (527.8 kB)
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審査結果要旨 : Summary of Thesis Review (487.4 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | 腫瘍マウスモデルにおいてプロリル水酸化酵素阻害剤による腫瘍血管の正常化は化学療法に対する感受性を回復させた | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | Tumour blood vessel normalisation by prolyl hydroxylase inhibitor repaired sensitivity to chemotherapy in a tumour mouse model | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| 著者 |
小山, 哲史
× 小山, 哲史× Koyama, Satoshi |
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| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Blood vessels are important tissue structures that deliver oxygen and nutrition. In tumour tissue, abnormal blood vessels, which are hyperpermeable and immature, are often formed; these tissues also have irregular vascularisation and intravasation. This situation leads to hypoperfusion in tumour tissue along with low oxygen and nutrition depletion; this is also called the tumour microenvironment and is characterised by hypoxia, depleted nutrition, low pH and high interstitial pressure. This environment induces resistance to anticancer drugs, which causes an increase in anticancer drug doses, leading to increased side effects. We hypothesised that normalised tumour blood vessels would improve tumour tissue perfusion, resupply nutrition and re-oxygenate the tumour tissue. Chemotherapy would then be more effective and cause a decrease in anticancer drug doses. Here we report a neovascularisation-inducing drug that improved tumour vascular abnormalities, such as low blood flow, blood leakage and abnormal vessel structure. These results could lead to not only an increased chemo-sensitivity and tissue-drug distribution but also an up-regulated efficiency for cancer chemotherapy. This suggests that tumour blood vessel normalisation therapy accompanied by angiogenesis may be a novel strategy for cancer therapy. | |||||
| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 15101 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 鳥取大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2017-09-30 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第866号 | |||||
| 権利 | ||||||
| 権利情報 | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the ma | |||||
| 情報源 | ||||||
| 関連名称 | Koyama, S. et al. Tumour blood vessel normalisation by prolyl hydroxylase inhibitor repaired sensitivity to chemotherapy in a tumour mouse model. Sci. Rep. 7, 45621; doi: 10.1038/srep45621 (2017). | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.nature.com/articles/srep45621 | |||||
| 関連名称 | http://www.nature.com/articles/srep45621 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
