{"_buckets": {"deposit": "9d4eedf4-0075-41f4-8d1f-ddd8d5376536"}, "_deposit": {"created_by": 10, "id": "5850", "owners": [10], "pid": {"revision_id": 0, "type": "depid", "value": "5850"}, "status": "published"}, "_oai": {"id": "oai:repository.lib.tottori-u.ac.jp:00005850", "sets": ["13", "9", "58"]}, "author_link": ["40032", "40033"], "item_10006_checkbox_25": {"attribute_name": "部局名", "attribute_value_mlt": [{"subitem_checkbox_item": ["i-gakubu"]}]}, "item_10006_date_granted_11": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2017-09-30"}]}, "item_10006_degree_grantor_9": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "鳥取大学"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "15101", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_10006_degree_name_8": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)", "subitem_degreename_language": "ja"}]}, "item_10006_description_7": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Blood vessels are important tissue structures that deliver oxygen and nutrition. In tumour tissue, abnormal blood vessels, which are hyperpermeable and immature, are often formed; these tissues also have irregular vascularisation and intravasation. This situation leads to hypoperfusion in tumour tissue along with low oxygen and nutrition depletion; this is also called the tumour microenvironment and is characterised by hypoxia, depleted nutrition, low pH and high interstitial pressure. This environment induces resistance to anticancer drugs, which causes an increase in anticancer drug doses, leading to increased side effects. We hypothesised that normalised tumour blood vessels would improve tumour tissue perfusion, resupply nutrition and re-oxygenate the tumour tissue. Chemotherapy would then be more effective and cause a decrease in anticancer drug doses. Here we report a neovascularisation-inducing drug that improved tumour vascular abnormalities, such as low blood flow, blood leakage and abnormal vessel structure. These results could lead to not only an increased chemo-sensitivity and tissue-drug distribution but also an up-regulated efficiency for cancer chemotherapy. This suggests that tumour blood vessel normalisation therapy accompanied by angiogenesis may be a novel strategy for cancer therapy.", "subitem_description_type": "Other"}]}, "item_10006_dissertation_number_12": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第866号"}]}, "item_10006_relation_14": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "Koyama, S. et al. Tumour blood vessel normalisation by prolyl hydroxylase inhibitor repaired sensitivity to chemotherapy in a tumour mouse model. Sci. Rep. 7, 45621; doi: 10.1038/srep45621 (2017)."}]}]}, "item_10006_relation_15": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://www.nature.com/articles/srep45621"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.nature.com/articles/srep45621", "subitem_relation_type_select": "URI"}}]}, "item_10006_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article\u0027s Creative Commons license, unless indicated otherwise in the credit line; if the ma"}]}, "item_10006_text_23": {"attribute_name": "EARMAS ID", "attribute_value_mlt": [{"subitem_text_value": "5634"}]}, "item_10006_version_type_18": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "小山, 哲史"}, {"creatorName": "コヤマ, サトシ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "40032", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koyama, Satoshi", "creatorNameLang": "en"}, {"creatorName": "コヤマ, サトシ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "40033", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-05-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "G11_15101A00866.pdf", "filesize": [{"value": "706.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article\u0027s Creative Commons license, unless indicated otherwise in the credit line; if the ma", "licensetype": "license_note", "mimetype": "application/pdf", "size": 706400.0, "url": {"label": "本文 : Full Text", "objectType": "fulltext", "url": "https://repository.lib.tottori-u.ac.jp/record/5850/files/G11_15101A00866.pdf"}, "version_id": "e5f87574-0d97-4224-81cb-5fbe9870c284"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-12-29"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "G11_15101A00866R.pdf", "filesize": [{"value": "527.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.", "licensetype": "license_note", "mimetype": "application/pdf", "size": 527800.0, "url": {"label": "要旨 : Summary", "objectType": "abstract", "url": "https://repository.lib.tottori-u.ac.jp/record/5850/files/G11_15101A00866R.pdf"}, "version_id": "8a94095b-5528-4430-8453-4435c3e9ea41"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-12-29"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "G11_15101A00866S.pdf", "filesize": [{"value": "487.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.", "licensetype": "license_note", "mimetype": "application/pdf", "size": 487400.0, "url": {"label": "審査結果要旨 : Summary of Thesis Review", "objectType": "abstract", "url": "https://repository.lib.tottori-u.ac.jp/record/5850/files/G11_15101A00866S.pdf"}, "version_id": "46f7c541-3ed9-4ba7-b3e1-a1753d29de7d"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "腫瘍マウスモデルにおいてプロリル水酸化酵素阻害剤による腫瘍血管の正常化は化学療法に対する感受性を回復させた", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "腫瘍マウスモデルにおいてプロリル水酸化酵素阻害剤による腫瘍血管の正常化は化学療法に対する感受性を回復させた", "subitem_title_language": "ja"}, {"subitem_title": "Tumour blood vessel normalisation by prolyl hydroxylase inhibitor repaired sensitivity to chemotherapy in a tumour mouse model", "subitem_title_language": "en"}]}, "item_type_id": "10006", "owner": "10", "path": ["13", "9", "58"], "permalink_uri": "https://repository.lib.tottori-u.ac.jp/records/5850", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2018-06-22"}, "publish_date": "2018-06-22", "publish_status": "0", "recid": "5850", "relation": {}, "relation_version_is_last": true, "title": ["腫瘍マウスモデルにおいてプロリル水酸化酵素阻害剤による腫瘍血管の正常化は化学療法に対する感受性を回復させた"], "weko_shared_id": -1}