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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
  1. 資料タイプ一覧
  2. 学位論文(要旨のみのもの含む)
  1. 博士学位論文
  2. 博士(医学)

血清脂肪酸結合タンパク4(FABP4)濃度は末梢組織でのインスリン抵抗性と相関するという臨床研究

https://repository.lib.tottori-u.ac.jp/records/5864
https://repository.lib.tottori-u.ac.jp/records/5864
b22285e8-31c0-4278-961d-2839d7a5d28a
名前 / ファイル ライセンス アクション
G11_15101A00872.pdf 本文 : Full Text (1.2 MB)
G11_15101A00872R.pdf 要旨 : Summary (544.2 kB)
G11_15101A00872S.pdf 審査結果要旨 : Summary of Thesis Review (504.5 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-06-22
タイトル
タイトル 血清脂肪酸結合タンパク4(FABP4)濃度は末梢組織でのインスリン抵抗性と相関するという臨床研究
言語 ja
タイトル
タイトル Serum fatty acid-binding protein 4 (FABP4) concentration is associated with insulin resistance in peripheral tissues, A clinical study
言語 en
言語
言語 eng
資源タイプ
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
著者 中村, 理沙

× 中村, 理沙

WEKO 40038

中村, 理沙

ja-Kana ナカムラ, リサ

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Nakamura, Risa

× Nakamura, Risa

WEKO 40039

en Nakamura, Risa

ja-Kana ナカムラ, リサ

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抄録
内容記述タイプ Other
内容記述 Type 2 diabetes mellitus (T2DM) is caused by insulin resistance and β cell dysfunction. In recent studies reported that several markers associated with insulin sensitivity in skeletal muscle, Adiponectin and other parameters, such as fatty acid-binding protein (FABP4), have been reported to regulate insulin resistance, but it remains unclear which factor mostly affects insulin resistance in T2DM. In this cross-sectional study, we evaluated the relationships between several kinds of biomarkers and insulin resistance, and insulin secretion in T2DM and healthy controls. We recruited 30 participants (12 T2DM and 18 non-diabetic healthy controls). Participants underwent a meal tolerance test during which plasma glucose, insulin and serum C-peptide immunoreactivity were measured. We performed a hyperinsulinemic-euglycemic clamp and measured the glucose-disposal rate (GDR). The fasting serum levels of adiponectin, insulin-like growth factor-1, irisin, autotaxin, FABP4 and interleukin-6 were measured by ELISA. We found a strong negative correlation between FABP4 concentration and GDR in T2DM (r = -0.657, p = 0.020). FABP4 also was positively correlated with insulin secretion during the meal tolerance test in T2DM (IRI (120): r = 0.604, p = 0.038) and was positively related to the insulinogenic index in non-DM subjects (r = 0.536, p = 0.022). Autotaxin was also related to GDR. However, there was no relationship with insulin secretion. We found that serum FABP4 concentration were associated with insulin resistance and secretion in T2DM. This suggests that FABP4 may play an important role in glucose homeostasis.
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 15101
言語 ja
学位授与機関名 鳥取大学
学位授与年月日
学位授与年月日 2018-03-01
学位授与番号
学位授与番号 甲第872号
権利
権利情報 © 2017 Nakamura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credit
情報源
関連名称 This research was published by PLOS ONE : Nakamura R, Okura T, Fujioka Y, Sumi K, Matsuzawa K, Izawa S, et al. (2017) Serum fatty acid-binding protein 4 (FABP4) concentration is associated with insulin resistance in peripheral tissues, A clinical study. P
関連サイト
識別子タイプ URI
関連識別子 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179737
関連名称 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179737
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出版タイプ VoR
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