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血清脂肪酸結合タンパク4（FABP4）濃度は末梢組織でのインスリン抵抗性と相関するという臨床研究
https://repository.lib.tottori-u.ac.jp/records/5864
https://repository.lib.tottori-u.ac.jp/records/5864b22285e8-31c0-4278-961d-2839d7a5d28a
| 名前 / ファイル | ライセンス | アクション |
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本文 : Full Text (1.2 MB)
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要旨 : Summary (544.2 kB)
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審査結果要旨 : Summary of Thesis Review (504.5 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | 血清脂肪酸結合タンパク4（FABP4）濃度は末梢組織でのインスリン抵抗性と相関するという臨床研究 | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | Serum fatty acid-binding protein 4 (FABP4) concentration is associated with insulin resistance in peripheral tissues, A clinical study | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| 著者 |
中村, 理沙
× 中村, 理沙× Nakamura, Risa |
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| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Type 2 diabetes mellitus (T2DM) is caused by insulin resistance and β cell dysfunction. In recent studies reported that several markers associated with insulin sensitivity in skeletal muscle, Adiponectin and other parameters, such as fatty acid-binding protein (FABP4), have been reported to regulate insulin resistance, but it remains unclear which factor mostly affects insulin resistance in T2DM. In this cross-sectional study, we evaluated the relationships between several kinds of biomarkers and insulin resistance, and insulin secretion in T2DM and healthy controls. We recruited 30 participants (12 T2DM and 18 non-diabetic healthy controls). Participants underwent a meal tolerance test during which plasma glucose, insulin and serum C-peptide immunoreactivity were measured. We performed a hyperinsulinemic-euglycemic clamp and measured the glucose-disposal rate (GDR). The fasting serum levels of adiponectin, insulin-like growth factor-1, irisin, autotaxin, FABP4 and interleukin-6 were measured by ELISA. We found a strong negative correlation between FABP4 concentration and GDR in T2DM (r = -0.657, p = 0.020). FABP4 also was positively correlated with insulin secretion during the meal tolerance test in T2DM (IRI (120): r = 0.604, p = 0.038) and was positively related to the insulinogenic index in non-DM subjects (r = 0.536, p = 0.022). Autotaxin was also related to GDR. However, there was no relationship with insulin secretion. We found that serum FABP4 concentration were associated with insulin resistance and secretion in T2DM. This suggests that FABP4 may play an important role in glucose homeostasis. | |||||
| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 15101 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 鳥取大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2018-03-01 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第872号 | |||||
| 権利 | ||||||
| 権利情報 | © 2017 Nakamura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credit | |||||
| 情報源 | ||||||
| 関連名称 | This research was published by PLOS ONE : Nakamura R, Okura T, Fujioka Y, Sumi K, Matsuzawa K, Izawa S, et al. (2017) Serum fatty acid-binding protein 4 (FABP4) concentration is associated with insulin resistance in peripheral tissues, A clinical study. P | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179737 | |||||
| 関連名称 | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179737 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
