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特発性間質性肺炎の急性増悪の治療のための白血球除去療法 : パイロット研究
https://repository.lib.tottori-u.ac.jp/records/5868
https://repository.lib.tottori-u.ac.jp/records/5868d70cef66-89df-4c18-97e4-02a8705f4cfd
| 名前 / ファイル | ライセンス | アクション |
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本文 : Full Text (835.1 kB)
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要旨 : Summary (519.3 kB)
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審査結果要旨 : Summary of Thesis Review (476.0 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | 特発性間質性肺炎の急性増悪の治療のための白血球除去療法 : パイロット研究 | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | Leukocytapheresis for the treatment of acute exacerbation of idiopathic interstitial pneumonias : a pilot study | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | acute exacerbation | |||||
| キーワード | ||||||
| 主題 | idiopathic interstitial pneumonia | |||||
| キーワード | ||||||
| 主題 | idiopathic pulmonary fibrosis | |||||
| キーワード | ||||||
| 主題 | leukocytapheresis | |||||
| キーワード | ||||||
| 主題 | nonspecific interstitial pneumonia | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | acute exacerbation | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | idiopathic interstitial pneumonia | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | idiopathic pulmonary fibrosis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | leukocytapheresis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | nonspecific interstitial pneumonia | |||||
| 資源タイプ | ||||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| 著者 |
山本, 章祐
× 山本, 章祐 |
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| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Objective: Idiopathic interstitial pneumonias (IIPs) are a group of heterogeneous diffuse parenchymal lung disorders of unknown etiology. An acute exacerbation (AE) is an acute respiratory deterioration that occurs in IIPs. The prognosis of AE of IIPs (AE-IIPs) is extremely severe; however, no established therapies exist. We aimed to evaluate the efficacy of leukocytapheresis (LCAP) to treat patients with AE-IIPs. Patients and Methods: Six chronic IIPs patients who developed AE were enrolled in this study. We performed LCAP on days 2, 3, 9 and 10 in all six patients. All patients were also treated with high-dose corticosteroids and a continuous administration of low-molecular-weight heparin. We observed 30-day survival after the diagnosis of AE to evaluate the efficacy of LCAP. We also assessed oxygenation, high-resolution computed tomography (HRCT) findings, and certain chemical mediators in the peripheral blood. Results: Five of six patients survived more than 30 days. One patient died of progressive respiratory failure. Oxygenation and HRCT findings tended to improve in all survivors. The serum levels of lactate dehydrogenase, high mobility group box-1, and interleukin-18 were significantly decreased statistically post-LCAP. No severe adverse events occurred. Conclusion: We suggest that LCAP is a safe and effective therapy for treating patients with AE-IIPs. J. Med. Invest. 64: 110-116, February, 2017 | |||||
| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 15101 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 鳥取大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2018-03-01 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第876号 | |||||
| 権利 | ||||||
| 権利情報 | 注があるものを除き、この著作物は日本国著作権法により保護されています。 | |||||
| 情報源 | ||||||
| 関連名称 | This research was published by The Journal of Medical Investigation: YAMAMOTO, Akihiro, et al. Leukocytapheresis for the treatment of acute exacerbation of idiopathic interstitial pneumonias: a pilot study. The Journal of Medical Investigation, 2017, 64.1 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/jmi/64/1.2/64_110/_article | |||||
| 関連名称 | https://www.jstage.jst.go.jp/article/jmi/64/1.2/64_110/_article | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
