{"_buckets": {"deposit": "e4870d07-3da4-4490-8f87-a78479b418fb"}, "_deposit": {"created_by": 10, "id": "5868", "owners": [10], "pid": {"revision_id": 0, "type": "depid", "value": "5868"}, "status": "published"}, "_oai": {"id": "oai:repository.lib.tottori-u.ac.jp:00005868", "sets": ["13", "9", "58"]}, "author_link": ["4279"], "item_10006_checkbox_25": {"attribute_name": "部局名", "attribute_value_mlt": [{"subitem_checkbox_item": ["i-gakubu"]}]}, "item_10006_date_granted_11": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2018-03-01"}]}, "item_10006_degree_grantor_9": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "鳥取大学"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "15101", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_10006_degree_name_8": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)", "subitem_degreename_language": "ja"}]}, "item_10006_description_7": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Objective: Idiopathic interstitial pneumonias (IIPs) are a group of heterogeneous diffuse parenchymal lung disorders of unknown etiology. An acute exacerbation (AE) is an acute respiratory deterioration that occurs in IIPs. The prognosis of AE of IIPs (AE-IIPs) is extremely severe; however, no established therapies exist. We aimed to evaluate the efficacy of leukocytapheresis (LCAP) to treat patients with AE-IIPs. Patients and Methods: Six chronic IIPs patients who developed AE were enrolled in this study. We performed LCAP on days 2, 3, 9 and 10 in all six patients. All patients were also treated with high-dose corticosteroids and a continuous administration of low-molecular-weight heparin. We observed 30-day survival after the diagnosis of AE to evaluate the efficacy of LCAP. We also assessed oxygenation, high-resolution computed tomography (HRCT) findings, and certain chemical mediators in the peripheral blood. Results: Five of six patients survived more than 30 days. One patient died of progressive respiratory failure. Oxygenation and HRCT findings tended to improve in all survivors. The serum levels of lactate dehydrogenase, high mobility group box-1, and interleukin-18 were significantly decreased statistically post-LCAP. No severe adverse events occurred. Conclusion: We suggest that LCAP is a safe and effective therapy for treating patients with AE-IIPs. J. Med. Invest. 64: 110-116, February, 2017", "subitem_description_type": "Other"}]}, "item_10006_dissertation_number_12": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第876号"}]}, "item_10006_relation_14": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "This research was published by The Journal of Medical Investigation: YAMAMOTO, Akihiro, et al. Leukocytapheresis for the treatment of acute exacerbation of idiopathic interstitial pneumonias: a pilot study. The Journal of Medical Investigation, 2017, 64.1"}]}]}, "item_10006_relation_15": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://www.jstage.jst.go.jp/article/jmi/64/1.2/64_110/_article"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.jstage.jst.go.jp/article/jmi/64/1.2/64_110/_article", "subitem_relation_type_select": "URI"}}]}, "item_10006_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "注があるものを除き、この著作物は日本国著作権法により保護されています。"}]}, "item_10006_text_23": {"attribute_name": "EARMAS ID", "attribute_value_mlt": [{"subitem_text_value": "5652"}]}, "item_10006_version_type_18": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", 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"licensefree": "注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.", "licensetype": "license_note", "mimetype": "application/pdf", "size": 835100.0, "url": {"label": "本文 : Full Text", "objectType": "fulltext", "url": "https://repository.lib.tottori-u.ac.jp/record/5868/files/G11_15101A00876.pdf"}, "version_id": "01b7c14b-ebba-431a-92fd-d371060e7985"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-05-31"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "G11_15101A00876R.pdf", "filesize": [{"value": "519.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.", "licensetype": "license_note", "mimetype": "application/pdf", "size": 519299.99999999994, "url": {"label": "要旨 : Summary", "objectType": "abstract", "url": "https://repository.lib.tottori-u.ac.jp/record/5868/files/G11_15101A00876R.pdf"}, "version_id": "616bb21a-c20b-4bfa-b2b7-df1cfc50b8a0"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-05-31"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "G11_15101A00876S.pdf", "filesize": [{"value": "476.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.", "licensetype": "license_note", "mimetype": "application/pdf", "size": 476000.0, "url": {"label": "審査結果要旨 : Summary of Thesis Review", "objectType": "abstract", "url": "https://repository.lib.tottori-u.ac.jp/record/5868/files/G11_15101A00876S.pdf"}, "version_id": "fdc5ed7f-2083-451b-9729-fb073fa9746b"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "acute exacerbation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "idiopathic interstitial pneumonia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "idiopathic pulmonary fibrosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "leukocytapheresis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "nonspecific interstitial pneumonia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "acute exacerbation", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "idiopathic interstitial pneumonia", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "idiopathic pulmonary fibrosis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "leukocytapheresis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "nonspecific interstitial pneumonia", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "特発性間質性肺炎の急性増悪の治療のための白血球除去療法 : パイロット研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "特発性間質性肺炎の急性増悪の治療のための白血球除去療法 : パイロット研究", "subitem_title_language": "ja"}, {"subitem_title": "Leukocytapheresis for the treatment of acute exacerbation of idiopathic interstitial pneumonias : a pilot study", "subitem_title_language": "en"}]}, "item_type_id": "10006", "owner": "10", "path": ["13", "9", "58"], "permalink_uri": "https://repository.lib.tottori-u.ac.jp/records/5868", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2018-06-22"}, "publish_date": "2018-06-22", "publish_status": "0", "recid": "5868", "relation": {}, "relation_version_is_last": true, "title": ["特発性間質性肺炎の急性増悪の治療のための白血球除去療法 : パイロット研究"], "weko_shared_id": -1}