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日本人の潰瘍性大腸炎患者におけるヒト白血球抗原と臨床的特徴の関連
https://repository.lib.tottori-u.ac.jp/records/5873
https://repository.lib.tottori-u.ac.jp/records/5873adccc4bf-8597-4729-ba61-249e808387e4
| 名前 / ファイル | ライセンス | アクション |
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本文 : Full Text (548.8 kB)
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要旨 : Summary (515.5 kB)
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審査結果要旨 : Summary of Thesis Review (472.2 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | 日本人の潰瘍性大腸炎患者におけるヒト白血球抗原と臨床的特徴の関連 | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | Association of Clinical Features with Human Leukocyte Antigen in Japanese Patients with Ulcerative Colitis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | HLA | |||||
| キーワード | ||||||
| 主題 | inflammatory bowel disease | |||||
| キーワード | ||||||
| 主題 | Japanese | |||||
| キーワード | ||||||
| 主題 | ulcerative colitis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | HLA | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | inflammatory bowel disease | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Japanese | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | ulcerative colitis | |||||
| 資源タイプ | ||||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| 著者 |
岩本, 拓
× 岩本, 拓× Iwamoto, Taku |
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| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 【Background】 The human leukocyte antigen (HLA) region has been found to be involved in the pathogenesis of inflammatory bowel disease (IBD), which is classified into ulcerative colitis (UC) and Crohn’s disease (CD), by genome-wide association studies. The aim of this study was to confirm whether HLA-alleles confer susceptibility to UC and to determine whether HLA-allel1es are associated with the clinical phenotypes in Japanese patients with UC. 【Methods】 In this study, HLA typing was performed by PCR-sequence-specific oligonucleotides (PCR-SSO) to confirm the correlation between UC and HLA alleles (for HLA-A, B, DRB1) in 45 Japanese UC patients. In addition, whether the HLA alleles are related to patient and clinical background characteristics was examined. 【Results】 Overall, 62.2%, and 66.7% of the 45 UC patients had HLA-B*52 and HLA-DRB1*15, respectively. These allele frequencies were significantly higher than in previously reported Japanese control persons (P < 0.0001). The frequencies of extraintestinal manifestations [odds ratio (OR) = 0.12, P = 0.039] and a history of colectomy (OR = 0.18, P = 0.046) were lower in HLA-B*52-positive UC patients than in HLA-B*52 negative UC patients. The white blood cell (WBC) count was significantly higher in HLA-DRB1*15-positive patients (9430 ± 4592/μL) than in HLA-DRB1*15-negative patients (6729 ± 2160/μL). Thus, HLA-B*52 and DRB1*15 appear to be associated with disease features and severity in Japanese UC patients. 【Conclusion】 These results indicate that HLA-B*52 and DRB1*15 are not only associated with overall UC susceptibility, but also with the clinical phenotypes in Japanese patients. | |||||
| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 15101 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 鳥取大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2018-03-01 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第881号 | |||||
| 権利 | ||||||
| 権利情報 | 注があるものを除き、この著作物は日本国著作権法により保護されています。 | |||||
| 情報源 | ||||||
| 関連名称 | This research was published by Yonago Acta Medica: Taku Iwamoto, Kazuo Yashima, Keiko Morio, Naoki Ueda, Yuichiro Ikebuchi, Koichiro Kawaguchi, Kenichi Harada and Hajime Isomoto. Association of Clinical Features with Human Leukocyte Antigen in Japanese Pa | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.lib.tottori-u.ac.jp/yam/yam/yam61-1/61-1contents.html | |||||
| 関連名称 | http://www.lib.tottori-u.ac.jp/yam/yam/yam61-1/61-1contents.html | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
