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コラーゲン誘発関節炎ラットにおける腰椎変化の組織学的評価
https://repository.lib.tottori-u.ac.jp/records/5874
https://repository.lib.tottori-u.ac.jp/records/5874a70cb3c6-a07d-49f5-a9a3-23f3b91d89ab
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
本文 : Full Text (2.3 MB)
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要旨 : Summary (526.3 kB)
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審査結果要旨 : Summary of Thesis Review (486.9 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | コラーゲン誘発関節炎ラットにおける腰椎変化の組織学的評価 | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | Histological Evaluation of Lumbar Spine Changes in Rats with Collagen-induced Arthritis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | collagen-induced arthritis rat | |||||
| キーワード | ||||||
| 主題 | lumbar spine | |||||
| キーワード | ||||||
| 主題 | rheumatoid arthritis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | collagen-induced arthritis rat | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | lumbar spine | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | rheumatoid arthritis | |||||
| 資源タイプ | ||||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| 著者 |
三原, 徳満
× 三原, 徳満× Mihara, Tokumitsu |
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| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 【Background】 To histologically evaluate lumbar involvement in rheumatoid arthritis (RA) by investigating rats with collagen-induced arthritis (CIA) and to assess the potential effects of RA on the discovertebral joints and facet joints. 【Methods】 Seven-month-old female Sprague-Dawley rats were divided into groups with CIA and without CIA (control). All rats were sacrificed at 8 weeks after initial sensitization and the lumbar spine (L5/6) was harvested. Then the lumbar spine block specimens were stained with Villaneuva bone stain and sectioned in the midsagittal plane. The left facet joints were also sectioned in the midaxial plane. Specimens were studied under a microscope and infiltration of inflammatory cells was investigated. 【Results】 In the CIA group, lumbar lesions were observed in 13/18 rats (76%). Lymphocytes infiltrated into the anterior rim of the vertebral bodies only in 2 rats, while lymphocytes infiltrated the facet joints only in 4 rats. Both sites were involved in 7 rats. In addition, osteoclasts invaded the anterior rim of the vertebral bodies and formed cavities that also contained lymphocytes. Formation of pannus was seen in the facet joints in 11/18 rats. 【Conclusion】 In CIA rats, infiltration of inflammatory cells into the anterior rim of the vertebral bodies alone or into the facet joints alone was demonstrated in 2 rats and 4 rats, respectively, while both sites were involved in 7 rats. Therefore, lesions at the anterior rim of the vertebral body did not arise secondary to facet joint involvement, but were caused by CIA along with synovial lesions of the facet joints. | |||||
| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 15101 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 鳥取大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2018-03-01 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第882号 | |||||
| 権利 | ||||||
| 権利情報 | 注があるものを除き、この著作物は日本国著作権法により保護されています。 | |||||
| 情報源 | ||||||
| 関連名称 | This research was published by Yonago Acta Medica: Tokumitsu Mihara, Shinji Tanishima, Atsushi Tanida, Ryota Teshima and Hideki Nagashima. Histological Evaluation of Lumbar Spine Changes in Rats with Collagen-induced Arthritis. Yonago Acta Medica, 2018, 6 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.lib.tottori-u.ac.jp/yam/yam/yam61-1/61-1contents.html | |||||
| 関連名称 | http://www.lib.tottori-u.ac.jp/yam/yam/yam61-1/61-1contents.html | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
