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Hepatic insulin clearance is increased in patients with high HbA1c type 2 diabetes: a preliminary report
https://repository.lib.tottori-u.ac.jp/records/7116
https://repository.lib.tottori-u.ac.jp/records/7116d8fc2d14-2ac8-490d-9a06-d62bcd156eac
| 名前 / ファイル | ライセンス | アクション |
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bodrc8(1)_bmjdrc-2019-001149.pdf (466.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2021-09-15 | |||||
| タイトル | ||||||
| タイトル | Hepatic insulin clearance is increased in patients with high HbA1c type 2 diabetes: a preliminary report | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | insulin | |||||
| キーワード | ||||||
| 主題 | clearance and action | |||||
| キーワード | ||||||
| 主題 | type 2 diabetes | |||||
| キーワード | ||||||
| 主題 | insulin clamp | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | insulin | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | clearance and action | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | type 2 diabetes | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | insulin clamp | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
大倉, 毅
× 大倉, 毅× 藤岡, 洋平× 松澤, 和彦× 伊澤, 正一郎× 大倉, 広子× 加藤, 雅彦× 今村, 武史× 谷口, 晋一× 山本, 一博× Nakamura, Risa× Anno, Mari× Ito, Yuichi× Kitao, Sonoko× Matsumoto, Kazuhisa× Shoji, Kyoko× Sumi, Keisuke× Izawa, Shoichiro× Okura, Hiroko× Ueta, Etsuko× Noma, Hisashi× Taniguchi, Shin-ichi |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Endocrinology and Metabolism, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Endocrinology and Metabolism, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Endocrinology and Metabolism, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Endocrinology and Metabolism, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Endocrinology and Metabolism, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Endocrinology and Metabolism, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Endocrinology and Metabolism, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Endocrinology and Metabolism, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Endocrinology and Metabolism, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Endocrinology and Metabolism, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Endocrinology and Metabolism, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Endocrinology and Metabolism, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | School of Health Science, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Institute of Statistical Mathematics | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | School of Health Science Major in Clinical LaboratoryScience, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Molecular Pharmacology, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Regional Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Endocrinology and Metabolism, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Introduction: Hepatic insulin clearance (HIC) is an important pathophysiology of type 2 diabetes. HIC was reported to decrease in patients with type 2 diabetes and metabolic syndrome. However, hyperglycemia was suggested to enhance HIC, and it is not known whether poorly controlled diabetes increases HIC in patients with type 2 diabetes. We investigated whether HIC was increased in patients with poorly controlled diabetes, and whether HIC was associated with insulin resistance and incretins. Research: design and methods We performed a meal tolerance test and the hyperinsulinemic–euglycemic clamp in 21 patients with type 2 diabetes. We calculated the postprandial C-peptide area under the curve (AUC)-to-insulin AUC ratio as the HIC; measured fasting and postprandial glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon levels and analyzed serum adiponectin and zinc transporter-8 (ZnT8) gene polymorphism. Results: The HIC significantly correlated with glycated hemoglobin (HbA1c) (r_S=0.58, p<0.01). In patients with high HIC above the median of 6.5, the mean HbA1c was significantly higher compared with low HIC below the median. Homeostatic model assessment (HOMA)-beta (r_S=−0.77, p<0.01) and HOMA-IR (r_S=−0.66, p<0.005) were correlated with HIC. The M/I value in the clamp study was correlated with HIC. GLP-1-AUC and GIP-AUC were not correlated with HIC. Glucagon-AUC was negatively correlated with HIC, but there were no significant differences between the high and low HIC groups. Adiponectin was positively correlated with HIC. The ZnT8 gene polymorphism did not affect HIC. Conclusions: These results suggest that HIC was increased in patients with high HbA1c type 2 diabetes, low insulin secretion, low insulin resistance and high adiponectin conditions. | |||||
| 書誌情報 |
BMJ OPEN DIABETES RESEARCH & CARE en : BMJ OPEN DIABETES RESEARCH & CARE 巻 8, 号 1, 発行日 2020-01 |
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| 出版者 | ||||||
| 出版者 | BMJ | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1136/bmjdrc-2019-001149 | |||||
| 権利 | ||||||
| 権利情報 | © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. | |||||
| 情報源 | ||||||
| 関連名称 | Okura Tsuyoshi, Fujioka Yohei, Nakamura Risa, et al. Hepatic insulin clearance is increased in patients with high HbA1c type 2 diabetes: a preliminary report. BMJ OPEN DIABETES RESEARCH & CARE. 2020. 8(1). doi:10.1136/bmjdrc-2019-001149 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://drc.bmj.com/content/8/1/e001149 | |||||
| 関連名称 | https://drc.bmj.com/content/8/1/e001149 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| EISSN | ||||||
| 値 | 20524897 | |||||
