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  1. 学部学科区分一覧
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Developing a mouse model of acute encephalopathy using low-dose lipopolysaccharide injection and hyperthermia treatment

https://repository.lib.tottori-u.ac.jp/records/7193
https://repository.lib.tottori-u.ac.jp/records/7193
ded3d615-3bb4-488c-9a23-6d5668c3bf74
名前 / ファイル ライセンス アクション
ebm244(9)_743.pdf ebm244(9)_743.pdf (1.4 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-01-16
タイトル
タイトル Developing a mouse model of acute encephalopathy using low-dose lipopolysaccharide injection and hyperthermia treatment
言語 en
言語
言語 eng
キーワード
主題 Hyperthermia
キーワード
主題 lipopolysaccharide
キーワード
主題 seizure
キーワード
主題 blood–brain barrier
キーワード
主題 vasogenic edema
キーワード
主題 acute encephalopathy
キーワード
言語 en
主題 Hyperthermia
キーワード
言語 en
主題 lipopolysaccharide
キーワード
言語 en
主題 seizure
キーワード
言語 en
主題 blood–brain barrier
キーワード
言語 en
主題 vasogenic edema
キーワード
言語 en
主題 acute encephalopathy
資源タイプ
資源タイプ journal article
著者 Kurata, Hirofumi

× Kurata, Hirofumi

WEKO 4935
e-Rad 00774837
研究者総覧鳥取大学 100001484

en Kurata, Hirofumi

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Saito, Kengo

× Saito, Kengo

WEKO 26642

en Saito, Kengo

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Kawashima, Fumiaki

× Kawashima, Fumiaki

WEKO 26643

en Kawashima, Fumiaki

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Ikenari, Takuya

× Ikenari, Takuya

WEKO 26644

en Ikenari, Takuya

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Oguri, Masayoshi

× Oguri, Masayoshi

WEKO 2761
研究者総覧鳥取大学 100001721

en Oguri, Masayoshi

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Saito, Yoshiaki

× Saito, Yoshiaki

WEKO 3096
e-Rad 30328421
研究者総覧鳥取大学 100001228

en Saito, Yoshiaki

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Maegaki, Yoshihiro

× Maegaki, Yoshihiro

WEKO 1921
e-Rad 80252849
研究者総覧鳥取大学 100000249

en Maegaki, Yoshihiro

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Mori, Tetsuji

× Mori, Tetsuji

WEKO 2308
e-Rad 30285043
研究者総覧鳥取大学 100001237

en Mori, Tetsuji

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著者所属(英)
言語 en
値 Department of Biological Regulation, School of Health Science, Faculty of Medicine, Tottori University / Division of Child Neurology, Department of Brain and Neurosciences, Tottori University / Department of Pediatrics, National Hospital Organization, Kumamoto Saishunso National Hospital
著者所属(英)
言語 en
値 Department of Biological Regulation, School of Health Science, Faculty of Medicine, Tottori University
著者所属(英)
言語 en
値 Department of Biological Regulation, School of Health Science, Faculty of Medicine, Tottori University
著者所属(英)
言語 en
値 Department of Biological Regulation, School of Health Science, Faculty of Medicine, Tottori University
著者所属(英)
言語 en
値 Department of Pathobiological Science and Technology, School of Health Science, Faculty of Medicine, Tottori University
著者所属(英)
言語 en
値 Division of Child Neurology, Department of Brain and Neurosciences, Tottori University
著者所属(英)
言語 en
値 Division of Child Neurology, Department of Brain and Neurosciences, Tottori University
著者所属(英)
言語 en
値 Department of Biological Regulation, School of Health Science, Faculty of Medicine, Tottori University
抄録
内容記述タイプ Other
内容記述 Acute encephalopathy (AE) is mainly reported in East Asia and, in most cases, results from pediatric viral infections, leading to fever, seizure, and loss of consciousness. Cerebral edema is the most important pathological symptom of AE. At present, AE is classified into four categories based on clinical and pathophysiological features, and cytokine storm-induced AE is the severest among them. The pathogenesis of AE is currently unclear; this can be attributed to the lack of a simple and convenient animal model for research. Here, we hypothesized that the induction of systemic inflammation using lipopolysaccharide (LPS) injection followed by hyperthermia (HT) treatment can be used to develop an animal model of cytokine storm-induced AE. Postnatal eight-day-old mouse pups were intraperitoneally injected with low-dose LPS (50 or 100 µg/kg) followed by HT treatment (41.5°C, 30 min). Histological analysis of their brains was subsequently performed. Fluorescein isothiocyanate assay combined with immunohistochemistry was used to elucidate blood–brain barrier (BBB) disruption. LPS (100 µg/kg) injection followed by HT treatment increased BBB permeability in the cerebral cortex and induced microglial activation. Astrocytic clasmatodendrosis was also evident. The brains of some pups exhibited small ischemic lesions, particularly in the cerebral cortex. Our results indicate that a low-dose LPS injection followed by HT treatment can produce symptoms of cytokine storm-induced AE, which is observed in diseases, such as acute necrotizing encephalopathy and hemorrhagic shock and encephalopathy syndrome. Thus, this mouse model can help to elucidate the pathogenetic mechanisms underlying AE.
書誌情報 Experimental biology and medicine
en : Experimental biology and medicine

巻 244, 号 9, p. 743-751, 発行日 2019-05-02
雑誌内区分
値 Research Article
出版者
出版者 Society for Experimental Biology and Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 15353702
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11503891
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1177/1535370219846497
権利
権利情報 Copyright © 2019 by the Society for Experimental Biology and Medicine.
情報源
関連名称 This research was published by the Society for Experimental Biology and Medicine: Kurata, H., Saito, K., Kawashima, F., Ikenari, T., Oguri, M., Saito, Y., … Mori, T. (2019). Developing a mouse model of acute encephalopathy using low-dose lipopolysaccharid
関連サイト
識別子タイプ URI
関連識別子 https://journals.sagepub.com/doi/abs/10.1177/1535370219846497
関連名称 https://journals.sagepub.com/doi/abs/10.1177/1535370219846497
関連サイト
識別子タイプ URI
関連識別子 https://repository.lib.tottori-u.ac.jp/6527
関連名称 https://repository.lib.tottori-u.ac.jp/6527
著者版フラグ
出版タイプ AM
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