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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
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  2. 学術雑誌論文

Conditional deletion of β1‐integrin in astroglia causes partial reactive gliosis

https://repository.lib.tottori-u.ac.jp/records/7201
https://repository.lib.tottori-u.ac.jp/records/7201
28374e37-3638-4af7-873e-165eff12ee6a
名前 / ファイル ライセンス アクション
g57(15)_1630.pdf g57(15)_1630.pdf (2.9 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-01-08
タイトル
タイトル Conditional deletion of β1‐integrin in astroglia causes partial reactive gliosis
言語 en
言語
言語 eng
キーワード
主題 astroglia
キーワード
主題 extracellular matrix
キーワード
主題 polarity
キーワード
言語 en
主題 astroglia
キーワード
言語 en
主題 extracellular matrix
キーワード
言語 en
主題 polarity
資源タイプ
資源タイプ journal article
著者 Robel, Stefanie

× Robel, Stefanie

WEKO 26676

en Robel, Stefanie

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Mori, Tetsuji

× Mori, Tetsuji

WEKO 2308
e-Rad 30285043
研究者総覧鳥取大学 100001237

en Mori, Tetsuji

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Zoubaa, Saida

× Zoubaa, Saida

WEKO 26677

en Zoubaa, Saida

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Schlegel, Jürgen

× Schlegel, Jürgen

WEKO 26678

en Schlegel, Jürgen

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Sirko, Svetlana

× Sirko, Svetlana

WEKO 26679

en Sirko, Svetlana

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Faissner, Andreas

× Faissner, Andreas

WEKO 26680

en Faissner, Andreas

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Goebbels, Sandra

× Goebbels, Sandra

WEKO 26681

en Goebbels, Sandra

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Dimou, Leda

× Dimou, Leda

WEKO 26682

en Dimou, Leda

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Götz, Magdalena

× Götz, Magdalena

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en Götz, Magdalena

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著者所属(英)
言語 en
値 Department of Physiological Genomics, Institute of Physiology, Ludwig‐Maximilians University Munich / Institute for Stem Cell Research, HelmholtzZentrum Munich
著者所属(英)
言語 en
値 Institute for Stem Cell Research, HelmholtzZentrum Munich
著者所属(英)
言語 en
値 Institute of Pathology, HelmholtzZentrum Munich
著者所属(英)
言語 en
値 Institute of Pathology, HelmholtzZentrum Munich
著者所属(英)
言語 en
値 Cell Morphology and Molecular Neurobiology, Ruhr-University-Bochum
著者所属(英)
言語 en
値 Cell Morphology and Molecular Neurobiology, Ruhr-University-Bochum
著者所属(英)
言語 en
値 Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine
著者所属(英)
言語 en
値 Department of Physiological Genomics, Institute of Physiology, Ludwig-Maximilians University Munich
著者所属(英)
言語 en
値 Department of Physiological Genomics, Institute of Physiology, Ludwig-Maximilians University Munich / Institute for Stem Cell Research, HelmholtzZentrum Munich / Munich Center for Integrated Protein Science, CiPSM
抄録
内容記述タイプ Other
内容記述 Astrocytes play many pivotal roles in the adult brain, including their reaction to injury. A hallmark of astrocytes is the contact of their endfeet with the basement membrane surrounding blood vessels, but still relatively little is known about the signaling mediated at the contact site. Here, we examine the role of β1‐integrin at this interface by its conditional deletion using different Cre lines. Thereby, the protein was reduced only at postnatal stages either in both glia and neurons or specifically only in neurons. Strikingly, only the former resulted in reactive gliosis, with the hallmarks of reactive astrocytes comprising astrocyte hypertrophy and up‐regulation of the intermediate filaments GFAP and vimentin as well as pericellular components, such as Tenascin‐C and the DSD‐1 proteoglycan. In addition, we also observed to a certain degree a non‐cell autonomous activation of microglial cells after conditional β1‐integrin deletion. However, these reactive astrocytes did not divide, suggesting that the loss of β1‐integrin‐mediated signaling is not sufficient to elicit proliferation of these cells as observed after brain injury. Interestingly, this partial reactive gliosis appeared in the absence of cell death and blood brain barrier disturbances. As these effects did not appear after neuron‐specific deletion of β1‐integrin, we conclude that β1‐integrin‐mediated signaling in astrocytes is required to promote their acquisition of a mature, nonreactive state. Alterations in β1‐integrin‐mediated signaling may hence be implicated in eliciting specific aspects of reactive gliosis after injury. © 2009 Wiley‐Liss, Inc.
書誌情報 Glia
en : Glia

巻 57, 号 15, p. 1630-1647, 発行日 2009-11-15
雑誌内区分
値 Original Article
出版者
出版者 Wiley‐Liss, Inc.
ISSN
収録物識別子タイプ ISSN
収録物識別子 10981136
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11620396
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1002/glia.20876
権利
権利情報 Copyright © 2009 Wiley‐Liss, Inc.
情報源
関連名称 This is the peer reviewed version of the following article: Robel, S., Mori, T., Zoubaa, S., Schlegel, J., Sirko, S., Faissner, A., Goebbels, S., Dimou, L. and Götz, M. (2009), Conditional deletion of β1‐integrin in astroglia causes partial reactive glios
関連サイト
識別子タイプ URI
関連識別子 https://onlinelibrary.wiley.com/doi/full/10.1002/glia.20876
関連名称 https://onlinelibrary.wiley.com/doi/full/10.1002/glia.20876
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出版タイプ AM
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