| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2020-01-08 |
| タイトル |
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タイトル |
Conditional deletion of β1‐integrin in astroglia causes partial reactive gliosis |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
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主題 |
astroglia |
| キーワード |
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主題Scheme |
Other |
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主題 |
extracellular matrix |
| キーワード |
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主題Scheme |
Other |
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主題 |
polarity |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
astroglia |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
extracellular matrix |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
polarity |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
Robel, Stefanie
Mori, Tetsuji
Zoubaa, Saida
Schlegel, Jürgen
Sirko, Svetlana
Faissner, Andreas
Goebbels, Sandra
Dimou, Leda
Götz, Magdalena
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| 著者所属（英） |
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言語 |
en |
|
値 |
Department of Physiological Genomics, Institute of Physiology, Ludwig‐Maximilians University Munich / Institute for Stem Cell Research, HelmholtzZentrum Munich |
| 著者所属（英） |
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言語 |
en |
|
値 |
Institute for Stem Cell Research, HelmholtzZentrum Munich |
| 著者所属（英） |
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言語 |
en |
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値 |
Institute of Pathology, HelmholtzZentrum Munich |
| 著者所属（英） |
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言語 |
en |
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値 |
Institute of Pathology, HelmholtzZentrum Munich |
| 著者所属（英） |
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言語 |
en |
|
値 |
Cell Morphology and Molecular Neurobiology, Ruhr-University-Bochum |
| 著者所属（英） |
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言語 |
en |
|
値 |
Cell Morphology and Molecular Neurobiology, Ruhr-University-Bochum |
| 著者所属（英） |
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言語 |
en |
|
値 |
Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine |
| 著者所属（英） |
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言語 |
en |
|
値 |
Department of Physiological Genomics, Institute of Physiology, Ludwig-Maximilians University Munich |
| 著者所属（英） |
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言語 |
en |
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値 |
Department of Physiological Genomics, Institute of Physiology, Ludwig-Maximilians University Munich / Institute for Stem Cell Research, HelmholtzZentrum Munich / Munich Center for Integrated Protein Science, CiPSM |
| 抄録 |
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内容記述タイプ |
Other |
|
内容記述 |
Astrocytes play many pivotal roles in the adult brain, including their reaction to injury. A hallmark of astrocytes is the contact of their endfeet with the basement membrane surrounding blood vessels, but still relatively little is known about the signaling mediated at the contact site. Here, we examine the role of β1‐integrin at this interface by its conditional deletion using different Cre lines. Thereby, the protein was reduced only at postnatal stages either in both glia and neurons or specifically only in neurons. Strikingly, only the former resulted in reactive gliosis, with the hallmarks of reactive astrocytes comprising astrocyte hypertrophy and up‐regulation of the intermediate filaments GFAP and vimentin as well as pericellular components, such as Tenascin‐C and the DSD‐1 proteoglycan. In addition, we also observed to a certain degree a non‐cell autonomous activation of microglial cells after conditional β1‐integrin deletion. However, these reactive astrocytes did not divide, suggesting that the loss of β1‐integrin‐mediated signaling is not sufficient to elicit proliferation of these cells as observed after brain injury. Interestingly, this partial reactive gliosis appeared in the absence of cell death and blood brain barrier disturbances. As these effects did not appear after neuron‐specific deletion of β1‐integrin, we conclude that β1‐integrin‐mediated signaling in astrocytes is required to promote their acquisition of a mature, nonreactive state. Alterations in β1‐integrin‐mediated signaling may hence be implicated in eliciting specific aspects of reactive gliosis after injury. © 2009 Wiley‐Liss, Inc. |
| 書誌情報 |
Glia
en : Glia
巻 57,
号 15,
p. 1630-1647,
発行日 2009-11-15
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| 雑誌内区分 |
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値 |
Original Article |
| 出版者 |
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出版者 |
Wiley‐Liss, Inc. |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
10981136 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11620396 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1002/glia.20876 |
| 権利 |
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権利情報 |
Copyright © 2009 Wiley‐Liss, Inc. |
| 情報源 |
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関連名称 |
This is the peer reviewed version of the following article: Robel, S., Mori, T., Zoubaa, S., Schlegel, J., Sirko, S., Faissner, A., Goebbels, S., Dimou, L. and Götz, M. (2009), Conditional deletion of β1‐integrin in astroglia causes partial reactive glios |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
https://onlinelibrary.wiley.com/doi/full/10.1002/glia.20876 |
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関連名称 |
https://onlinelibrary.wiley.com/doi/full/10.1002/glia.20876 |
| 著者版フラグ |
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出版タイプ |
AM |
g57(15)_1630.pdf (2.9 MB)
