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c-jun is differentially expressed in embryonic and adult neural precursor cells
https://repository.lib.tottori-u.ac.jp/records/7205
https://repository.lib.tottori-u.ac.jp/records/72050ac1003b-91a8-4177-aeb9-0cf965c83b58
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
hcb147(6)_721.pdf (2.9 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2020-01-16 | |||||
| タイトル | ||||||
| タイトル | c-jun is differentially expressed in embryonic and adult neural precursor cells | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | c-Jun | |||||
| キーワード | ||||||
| 主題 | Immunohistochemistry | |||||
| キーワード | ||||||
| 主題 | Development | |||||
| キーワード | ||||||
| 主題 | Adult neurogenesis | |||||
| キーワード | ||||||
| 主題 | Status epilepticus | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | c-Jun | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Immunohistochemistry | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Development | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Adult neurogenesis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Status epilepticus | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Kawashima, Fumiaki
× Kawashima, Fumiaki× Saito, Kengo× Kurata, Hirofumi× Maegaki, Yoshihiro× Mori, Tetsuji |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Biological Regulation, School of Health Science, Faculty of MedicineTottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Biological Regulation, School of Health Science, Faculty of MedicineTottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Biological Regulation, School of Health Science, Faculty of MedicineTottori University / Division of Child Neurology, Department of Brain and Neurosciences, Faculty of MedicineTottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Child Neurology, Department of Brain and Neurosciences, Faculty of MedicineTottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Biological Regulation, School of Health Science, Faculty of MedicineTottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | c-jun, a major component of AP-1 transcription factor, has a wide variety of functions. In the embryonic brain, c-jun mRNA is abundantly expressed in germinal layers around the ventricles. Although the subventricular zone (SVZ) of the adult brain is a derivative of embryonic germinal layers and contains neural precursor cells (NPCs), the c-jun expression pattern is not clear. To study the function of c-jun in adult neurogenesis, we analyzed c-jun expression in the adult SVZ by immunohistochemistry and compared it with that of the embryonic brain. We found that almost all proliferating embryonic NPCs expressed c-jun, but the number of c-jun immunopositive cells among proliferating adult NPCs was about half. In addition, c-jun was hardly expressed in post-mitotic migrating neurons in the embryonic brain, but the majority of c-jun immunopositive cells were tangentially migrating neuroblasts heading toward the olfactory bulb in the adult brain. In addition, status epilepticus is known to enhance the transient proliferation of adult NPCs, but the c-jun expression pattern was not significantly affected. These expression patterns suggest that c-jun has a pivotal role in the proliferation of embryonic NPCs, but it has also other roles in adult neurogenesis. | |||||
| 書誌情報 |
Histochemistry and cell biology en : Histochemistry and cell biology 巻 147, 号 6, p. 721-731, 発行日 2017-01-16 |
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| 雑誌内区分 | ||||||
| 値 | Original Paper | |||||
| 出版者 | ||||||
| 出版者 | Springer Berlin Heidelberg | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 09486143 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11033302 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s00418-016-1536-2 | |||||
| 権利 | ||||||
| 権利情報 | © Springer-Verlag Berlin Heidelberg 2017 | |||||
| 情報源 | ||||||
| 関連名称 | This is a post-peer-review, pre-copyedit version of an article published in [ Kawashima, F., Saito, K., Kurata, H. et al. Histochem Cell Biol (2017) 147: 721. https://doi.org/10.1007/s00418-016-1536-2 ]. The final authenticated version is available online | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://link.springer.com/article/10.1007%2Fs00418-016-1536-2 | |||||
| 関連名称 | https://link.springer.com/article/10.1007%2Fs00418-016-1536-2 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
