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Involvement of MAFB and MAFF in Retinoid-Mediated Suppression of Hepatocellular Carcinoma Invasion
https://repository.lib.tottori-u.ac.jp/records/7226
https://repository.lib.tottori-u.ac.jp/records/72262a483c47-4cba-480d-97cb-c81c636f7e17
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ijms19_ijms19051450.pdf (4.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2021-09-08 | |||||
| タイトル | ||||||
| タイトル | Involvement of MAFB and MAFF in Retinoid-Mediated Suppression of Hepatocellular Carcinoma Invasion | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | retinoids | |||||
| キーワード | ||||||
| 主題 | RAR alpha | |||||
| キーワード | ||||||
| 主題 | TFPI2 | |||||
| キーワード | ||||||
| 主題 | MAFB | |||||
| キーワード | ||||||
| 主題 | MAFF | |||||
| キーワード | ||||||
| 主題 | hepatocellular carcinoma | |||||
| キーワード | ||||||
| 主題 | invasion | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | retinoids | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | RAR alpha | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | TFPI2 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | MAFB | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | MAFF | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | hepatocellular carcinoma | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | invasion | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
土谷, 博之
× 土谷, 博之× Oura, Seiya |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Graduate School of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Graduate School of Pharmaceutical Sciences, Osaka University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Retinoids exert antitumor effects through the retinoic acid receptor α (RARα). In the present study, we sought to identify the factors involved in the RARα-mediated transcriptional regulation of the tumor suppressor gene and the tissue factor pathway inhibitor 2 (TFPI2) in hepatocellular carcinoma (HCC). All-trans-retinoic acid (ATRA) was used in the in vitro experiments. Cell invasiveness was measured using trans-well invasion assay. ATRA significantly increased TFPI2 expression through RARα in a human HCC cell line known as HuH7. TFPI2 was vital in the ATRA-mediated suppression of HuH7 cell invasion. The musculo-aponeurotic fibrosarcoma oncogene homolog B (MAFB) significantly enhanced the activation of the TFPI2 promoter via RARα while MAFF inhibited it. The knockdown of RARα or MAFB counteracted the ATRA-mediated suppression of HuH7 cell invasion while the knockdown of MAFF inhibited the invasion. TFPI2 expression in HCC tissues was significantly downregulated possibly due to the decreased expression of RARβ and MAFB. Patients with HCC expressing low MAFB and high MAFF levels showed the shortest disease-free survival time. These results suggest that MAFB and MAFF play critical roles in the antitumor effects of retinoids by regulating the expression of retinoid target genes such as TFPI2 and can be promising for developing therapies to combat HCC invasion. | |||||
| 書誌情報 |
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES en : INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 巻 19, 号 5, 発行日 2018-05 |
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| 出版者 | ||||||
| 出版者 | MDPI | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 14220067 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/ijms19051450 | |||||
| 権利 | ||||||
| 権利情報 | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||
| 情報源 | ||||||
| 関連名称 | Tsuchiya Hiroyuki, Oura Seiya. Involvement of MAFB and MAFF in Retinoid-Mediated Suppression of Hepatocellular Carcinoma Invasion. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2018. 19(5). doi:10.3390/ijms19051450 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.mdpi.com/1422-0067/19/5/1450 | |||||
| 関連名称 | https://www.mdpi.com/1422-0067/19/5/1450 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
