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Effectiveness of real-time PCR for diagnosis and prognosis of varicella-zoster virus keratitis
https://repository.lib.tottori-u.ac.jp/records/7233
https://repository.lib.tottori-u.ac.jp/records/7233684f4a8c-31a6-4577-b372-1d309b5d2cfc
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jjo62(4)_425.pdf (579.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2019-08-01 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Effectiveness of real-time PCR for diagnosis and prognosis of varicella-zoster virus keratitis | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題 | varicella-zoster virus keratitis | |||||||||||
| キーワード | ||||||||||||
| 主題 | real-time PCR | |||||||||||
| キーワード | ||||||||||||
| 主題 | herpes zoster ophthalmicus | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題 | varicella-zoster virus keratitis | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題 | real-time PCR | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題 | herpes zoster ophthalmicus | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ | journal article | |||||||||||
| 著者 |
Inata, Kodai
× Inata, Kodai× Miyazaki, Dai× Uotani, Ryu× Shimizu, Daisuke× Miyake, Atsuko× Shimizu, Yumiko× Inoue, Yoshitsugu
WEKO
4639
× Inata, Kodai× Uotani, Ryu× Shimizu, Daisuke× Miyake, Atsuko× Shimizu, Yumiko |
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| 著者所属 | ||||||||||||
| 値 | Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University | |||||||||||
| 著者所属 | ||||||||||||
| 値 | Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University | |||||||||||
| 著者所属 | ||||||||||||
| 値 | Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University | |||||||||||
| 著者所属 | ||||||||||||
| 値 | Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University | |||||||||||
| 著者所属 | ||||||||||||
| 値 | Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University | |||||||||||
| 著者所属 | ||||||||||||
| 値 | Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University | |||||||||||
| 著者所属 | ||||||||||||
| 値 | Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University | |||||||||||
| 著者所属（英） | ||||||||||||
| 言語 | en | |||||||||||
| 値 | Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University | |||||||||||
| 著者所属（英） | ||||||||||||
| 言語 | en | |||||||||||
| 値 | Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University | |||||||||||
| 著者所属（英） | ||||||||||||
| 言語 | en | |||||||||||
| 値 | Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University | |||||||||||
| 著者所属（英） | ||||||||||||
| 言語 | en | |||||||||||
| 値 | Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University | |||||||||||
| 著者所属（英） | ||||||||||||
| 言語 | en | |||||||||||
| 値 | Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University | |||||||||||
| 著者所属（英） | ||||||||||||
| 言語 | en | |||||||||||
| 値 | Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University | |||||||||||
| 著者所属（英） | ||||||||||||
| 言語 | en | |||||||||||
| 値 | Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | Pupose: To determine the efficacy of real-time PCR for the diagnosis and prognosis of varicella-zoster virus (VZV) keratitis. Study design: Retrospective case series. Methods: Patients: 545 consecutive patients with keratitis were examined to quantify copy numbers of VZV DNA by real-time PCR. Association of copy numbers of DNA of VZV to clinical signs and disease course was assessed using logistic regression analysis and Cox proportional hazard model. Results: Of the 545 eyes, 38 eyes (6.9%) were diagnosed as VZV keratitis. The copy numbers of the DNA of VZV (median: 104.19 copy) was significantly associated with diagnosis of VZV keratitis with the highest odds ratio (OR) of 3390 (for median copy) compared to clinical signs. Diagnostic accuracy of the VZV DNA copy indicated good diagnostic value of area under the curve (0.92) by receiver operating characteristic analysis, and detection of unrelated VZV DNA from the cornea was very rare (0.2%). When the VZV DNA copy and clinical signs were assessed for association with the disease course after herpes zoster ophthalmicus, the disease duration was significantly prolonged in VZV keratitis cases with higher numbers of VZV DNA copies, iritis, and history of recurrences. The amount of VZV DNA led to a continuous risk to prolong disease duration until the ocular inflammation subsides (hazard ratio (HR) 0.17, 95%CI: 0.07 - 0.42, for median copies). Conclusions: Higher VZV DNA copy numbers are associated with the refractoriness of VZV keratitis, and its evaluation may be a clinically useful way to diagnose and manage VZV keratitis. | |||||||||||
| 書誌情報 |
Japanese Journal of Ophthalmology en : Japanese Journal of Ophthalmology 巻 62, 号 4, p. 425-431, 発行日 2018-06-11 |
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| 出版者 | ||||||||||||
| 出版者 | Springer Japan | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 00215155 | |||||||||||
| 書誌レコードID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA00691177 | |||||||||||
| DOI | ||||||||||||
| 関連タイプ | isVersionOf | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.1007/s10384-018-0604-7 | |||||||||||
| 権利 | ||||||||||||
| 権利情報 | © Japanese Ophthalmological Society 2018 | |||||||||||
| 情報源 | ||||||||||||
| 関連名称 | Japanese Journal of Ophthalmology. 2018, 62(4), 425-431 This is a post-peer-review, pre-copyedit version of an article published in Japanese Journal of Ophthalmology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10384 | |||||||||||
| 関連サイト | ||||||||||||
| 識別子タイプ | URI | |||||||||||
| 関連識別子 | https://link.springer.com/article/10.1007%2Fs10384-018-0604-7 | |||||||||||
| 関連名称 | https://link.springer.com/article/10.1007%2Fs10384-018-0604-7 | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | AM | |||||||||||
