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Sulfatide species with various fatty acid chains in oligodendrocytes at different developmental stages determined by imaging mass spectrometry
https://repository.lib.tottori-u.ac.jp/records/7268
https://repository.lib.tottori-u.ac.jp/records/7268ef40251a-bb29-4456-8a8e-a1e0720af280
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jn140(3)_435.pdf (2.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2020-01-15 | |||||
| タイトル | ||||||
| タイトル | Sulfatide species with various fatty acid chains in oligodendrocytes at different developmental stages determined by imaging mass spectrometry | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | fatty acid chain | |||||
| キーワード | ||||||
| 主題 | HSO3‐3‐galactosylceramide | |||||
| キーワード | ||||||
| 主題 | imaging mass spectrometry | |||||
| キーワード | ||||||
| 主題 | myelin | |||||
| キーワード | ||||||
| 主題 | pro‐oligodendroblast | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | fatty acid chain | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | HSO3‐3‐galactosylceramide | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | imaging mass spectrometry | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | myelin | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | pro‐oligodendroblast | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Hirahara, Yukie
× Hirahara, Yukie× Wakabayashi, Taketoshi× Mori, Tetsuji× Koike, Taro× Yao, Ikuko× Tsuda, Masayuki× Honke, Koichi× Gotoh, Hitoshi× Ono, Katsuhiko× Yamada, Hisao |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy and Cell Science, Kansai Medical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy and Cell Science, Kansai Medical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy and Cell Science, Kansai Medical University / School of Health Science, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy and Cell Science, Kansai Medical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Optical Imaging, Institute for Medical Photonics Research, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | The Division of Laboratory Animal Science, Science Research Center, Kochi University Medical School | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Biochemistry, Kochi University Medical School | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Biology, Kyoto Prefectural University of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Biology, Kyoto Prefectural University of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy and Cell Science, Kansai Medical University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | HSO3‐3‐galactosylceramide (Sulfatide) species comprise the major glycosphingolipid components of oligodendrocytes and myelin and play functional roles in the regulation of oligodendrocyte maturation and myelin formation. Although various sulfatide species contain different fatty acids, it is unclear how these sulfatide species affect oligodendrogenesis and myelination. The O4 monoclonal antibody reaction with sulfatide has been widely used as a useful marker for oligodendrocytes and myelin. However, sulfatide synthesis during the pro‐oligodendroblast stage, where differentiation into the oligodendrocyte lineage has already occurred, has not been examined. Notably, this stage comprises O4‐positive cells. In this study, we identified a sulfatide species from the pro‐oligodendroblast‐to‐myelination stage by imaging mass spectrometry. The results demonstrated that short‐chain sulfatides with 16 carbon non‐hydroxylated fatty acids (C16) and 18 carbon non‐hydroxylated fatty acids (C18) or 18 carbon hydroxylated fatty acids (C18‐OH) existed in restricted regions of the early embryonic spinal cord, where pro‐oligodendroblasts initially appear, and co‐localized with Olig2‐positive pro‐oligodendroblasts. C18 and C18‐OH sulfatides also existed in isolated pro‐oligodendroblasts. C22‐OH sulfatide became predominant later in oligodendrocyte development and the longer C24 sulfatide was predominant in the adult brain. Additionally, the presence of each sulfatide species in a different area of the adult brain was demonstrated by imaging mass spectrometry at an increased lateral resolution. These findings indicated that O4 recognized sulfatides with short‐chain fatty acids in pro‐oligodendroblasts. Moreover, the fatty acid chain of the sulfatide became longer as the oligodendrocyte matured. Therefore, individual sulfatide species may have unique roles in oligodendrocyte maturation and myelination. | |||||
| 書誌情報 |
Journal of neurochemistry en : Journal of neurochemistry 巻 140, 号 3, p. 435-450, 発行日 2016-11-12 |
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| 雑誌内区分 | ||||||
| 値 | Original Article | |||||
| 出版者 | ||||||
| 出版者 | International Society for Neurochemistry | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 14714159 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11628230 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/jnc.13897 | |||||
| 権利 | ||||||
| 権利情報 | © 2016 International Society for Neurochemistry | |||||
| 情報源 | ||||||
| 関連名称 | This is the peer reviewed version of the following article: Hirahara, Y., Wakabayashi, T., Mori, T., Koike, T., Yao, I., Tsuda, M., Honke, K., Gotoh, H., Ono, K. and Yamada, H. (2017), Sulfatide species with various fatty acid chains in oligodendrocytes a | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://onlinelibrary.wiley.com/doi/full/10.1111/jnc.13897 | |||||
| 関連名称 | https://onlinelibrary.wiley.com/doi/full/10.1111/jnc.13897 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
