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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
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  2. 学術雑誌論文

Bladder dysfunction after acute urinary retention in the rats: a novel over active bladder model.

https://repository.lib.tottori-u.ac.jp/records/7304
https://repository.lib.tottori-u.ac.jp/records/7304
77a4722c-9f33-4d52-920b-4a9fb46b4d8d
名前 / ファイル ライセンス アクション
mcb333(1-2)_109.pdf mcb333(1-2)_109.pdf (15.9 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-06-22
タイトル
タイトル Bladder dysfunction after acute urinary retention in the rats: a novel over active bladder model.
言語 en
言語
言語 eng
キーワード
主題 Acute urinary retention
キーワード
主題 Over active bladder
キーワード
主題 Rat
キーワード
言語 en
主題 Acute urinary retention
キーワード
言語 en
主題 Over active bladder
キーワード
言語 en
主題 Rat
資源タイプ
資源タイプ journal article
著者 Saito, Motoaki

× Saito, Motoaki

WEKO 3089
e-Rad 60273893

Saito, Motoaki

en Saito, Motoaki

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Shimizu, Shogo

× Shimizu, Shogo

WEKO 27125

Shimizu, Shogo

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Kinoshita, Yukako

× Kinoshita, Yukako

WEKO 1530
e-Rad 50032214

Kinoshita, Yukako

en Kinoshita, Yukako

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Satoh, Itaru

× Satoh, Itaru

WEKO 27126

Satoh, Itaru

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Shomori, Kohei

× Shomori, Kohei

WEKO 3391
e-Rad 60314572

Shomori, Kohei

en Shomori, Kohei

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Dimitriadis, Fotios

× Dimitriadis, Fotios

WEKO 27127

Dimitriadis, Fotios

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Satoh, Keisuke

× Satoh, Keisuke

WEKO 3198
e-Rad 50125564

Satoh, Keisuke

en Satoh, Keisuke

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Shimizu, Shogo

× Shimizu, Shogo

WEKO 27128

en Shimizu, Shogo

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Satoh, Itaru

× Satoh, Itaru

WEKO 27129

en Satoh, Itaru

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Dimitriadis, Fotios

× Dimitriadis, Fotios

WEKO 27130

en Dimitriadis, Fotios

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著者所属
値 Division of Molecular Pharmacology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University
著者所属
値 Division of Molecular Pharmacology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University
著者所属
値 Division of Molecular Pharmacology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University
著者所属
値 Division of Molecular Pharmacology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University
著者所属
値 Division of Molecular Pharmacology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University
著者所属
値 Division of Molecular Pharmacology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University
著者所属
値 Division of Molecular Pharmacology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University
抄録
内容記述タイプ Other
内容記述 As there is increasing evidence that benign prostatic hyperplasia and its related acute urinary retention (AUR) induce over active bladder (OAB) syndrome, we investigated the effects of AUR on bladder function over a 4-week period in a rat model. Ten-week-old female Sprague-Dawley rats were used in this study. AUR was induced by clamping the distal urethra of each rat with a small clip, and then infusing 3 ml (0.6 ml/min) of saline with an infusion pump through a transurethral catheter (22G). The obstruction was sustained for 60 min and the clip was removed and then the bladder was allowed to drain through the catheter. The bladder function was estimated by voiding behavior studies (at 3 days, 1, 2, 3, and 4 weeks), cystometric studies (at 2 and 4 weeks) and organ bath studies using KCl and carbachol (at 2 and 4 weeks). Furthermore, we evaluated histological changes in the rat bladder 2 and 4 weeks after the induction of AUR. The same parameters were also measured in non-AUR rats (control group). The rat bladder weight in the AUR group at 2 weeks was significantly larger than that of the controls, and returned to the control level 4 weeks after the AUR episode. The voiding behavior studies showed significant increase in micturition frequency per day and decrease in single voiding volume 3 days after the induction of AUR, and this voiding behavior was continued for more than 2 weeks. The cystometric studies showed a significant decrease in single-voided volume at 2 weeks rat. However, no significant changes of the other parameters were observed in the rats. The histological studies showed significant infiltration of neutrophils and lymphocytes, as well as increase in turnover of epithelium in AUR rats at 2 weeks, while significant increases in fibrosis in submucosal layer were observed in AUR rats at 4 weeks. This study demonstrated that bladder dysfunction in the rat model caused by AUR needs more than 2 weeks of recovery period. The AUR-associated alterations in the bladder may represent a key clue to understand the underlying pathophysiological mechanisms, which take place in OAB syndrome.
書誌情報 Molecular and Cellular Biochemistry
en : Molecular and Cellular Biochemistry

巻 333, 号 1-2, p. 109-114, 発行日 2010-01
出版者
出版者 Springer
ISSN
収録物識別子タイプ ISSN
収録物識別子 03008177
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00745800
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1007/s11010-009-0210-6
権利
権利情報 The final publication is available at www.springerlink.com
情報源
関連名称 Molecular and Cellular Biochemistry 2010, 333(1-2):109–114
関連サイト
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1007/s11010-009-0210-6
関連名称 http://dx.doi.org/10.1007/s11010-009-0210-6
著者版フラグ
出版タイプ AM
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