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Endothelial dysfunction in the early- and late-stage type-2 diabetic Goto-Kakizaki rat aorta
https://repository.lib.tottori-u.ac.jp/records/7305
https://repository.lib.tottori-u.ac.jp/records/73053b289e55-c57b-4195-b56d-4a3f3d6a7794
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
mcb332(1-2)_95.pdf (424.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Endothelial dysfunction in the early- and late-stage type-2 diabetic Goto-Kakizaki rat aorta | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Diabetes | |||||
| キーワード | ||||||
| 主題 | Goto-Kakizaki (GK) rat | |||||
| キーワード | ||||||
| 主題 | Aorta | |||||
| キーワード | ||||||
| 主題 | Nitric oxide synthase | |||||
| キーワード | ||||||
| 主題 | Aging | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Diabetes | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Goto-Kakizaki (GK) rat | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Aorta | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Nitric oxide synthase | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Aging | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Kazuyama, Emi
× Kazuyama, Emi× Saito, Motoaki× Kinoshita, Yukako× Satoh, Itaru× Dimitriadis, Fotios× Satoh, Keisuke× Kazuyama, Emi× Satoh, Itaru× Dimitriadis, Fotios |
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| 著者所属 | ||||||
| 値 | Division of Molecular Pharmacology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Division of Molecular Pharmacology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Division of Molecular Pharmacology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Division of Molecular Pharmacology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Division of Molecular Pharmacology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Division of Molecular Pharmacology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | As there are increasing evidences that human diabetes induces cardiovascular dysfunction, we investigated the type-2 diabetes-induced endothelial dysfunction in the early and late-stage Goto-Kakizaki (GK) rat aorta. We performed organ bath studies, and examined the changes in expression levels of muscarinic M(3) receptor, endothelial, inducible, and neuronal nitric oxide synthase (eNOS, iNOS, and nNOS, respectively) mRNAs in the rat aorta utilizing real-time polymerase chain reaction in 12-week-old and 70-week-old GK rats as well as in age-matched Wistar rats. In the 12-week-old GK rat aorta, a significant increase in norepinephrine-induced contraction and a significant decrease in acetylcholine-induced relaxation as well as significant increases in expression levels of muscarinic M(3) receptor and eNOS and a significant decrease in nNOS mRNAs were observed compared to age-matched controls. In the older GK rat aorta, significant decreases in acetylcholine- and nitroglycerine-induced relaxations as well as significant decreases in the expression levels of muscarinic M(3) receptor, eNOS, iNOS, and nNOS mRNAs were observed compared to those in the younger GK rats. In contrast, although significant decreases in acetylcholine and nitroglycerine-induced relaxations were observed, the expression levels of muscarinic M(3) receptor, eNOS, iNOS, and nNOS mRNAs in the older Wistar rats aorta were unchanged, increased, increased and decreased, respectively, compared to the younger Wistar rat aorta. These results indicate that endothelial dysfunction in the rat aorta progresses with age and development of diabetes condition, and that decreased relaxations in the late-stage rat aorta may be due to these alterations. | |||||
| 書誌情報 |
Molecular and Cellular Biochemistry en : Molecular and Cellular Biochemistry 巻 332, 号 1-2, p. 95-102, 発行日 2009-12 |
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| 出版者 | ||||||
| 出版者 | Springer | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03008177 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00745800 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s11010-009-0178-2 | |||||
| 権利 | ||||||
| 権利情報 | The final publication is available at www.springerlink.com | |||||
| 情報源 | ||||||
| 関連名称 | Molecular and Cellular Biochemistry 2009, 332(1-2):95–102 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1007/s11010-009-0178-2 | |||||
| 関連名称 | http://dx.doi.org/10.1007/s11010-009-0178-2 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
