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Distinct Modes of Neuron Addition in Adult Mouse Neurogenesis
https://repository.lib.tottori-u.ac.jp/records/7384
https://repository.lib.tottori-u.ac.jp/records/738435bd6495-e4e1-473b-8047-2be8475dd203
| 名前 / ファイル | ライセンス | アクション |
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jn27(40)_10906.pdf (442.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2019-12-24 | |||||
| タイトル | ||||||
| タイトル | Distinct Modes of Neuron Addition in Adult Mouse Neurogenesis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | granule cells | |||||
| キーワード | ||||||
| 主題 | periglomerular neurons | |||||
| キーワード | ||||||
| 主題 | dentate gyrus | |||||
| キーワード | ||||||
| 主題 | olfactory bulb | |||||
| キーワード | ||||||
| 主題 | neuron integration | |||||
| キーワード | ||||||
| 主題 | neural network | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | granule cells | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | periglomerular neurons | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | dentate gyrus | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | olfactory bulb | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | neuron integration | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | neural network | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Ninkovic, Jovica
× Ninkovic, Jovica× Mori, Tetsuji× Götz, Magdalena |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Institute for Stem Cell Research, Gesellschaft fu¨r Strahlenforschung-National Research Institute for Environment and Health | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Institute for Stem Cell Research, Gesellschaft fu¨r Strahlenforschung-National Research Institute for Environment and Health | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Physiological Genomics, University of Munich | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Adult neurogenesis is restricted to two distinct areas of the mammalian brain: the olfactory bulb (OB) and the dentate gyrus (DG). Despite its spatial restriction, adult neurogenesis is of crucial importance for sensory processing and learning and memory. Although it has been shown that tens of thousands of new neurons arrive in the OB and DG every day with about half of them surviving after integration, the total contribution of adult neurogenesis to the pre-existing network remains mostly unknown. This is because of previous approaches labeling only a small proportion of adult-generated neurons. Here, we used genetic fate mapping to follow the majority of adult-generated neurons over long periods. Our data demonstrate two distinct modes of neuron addition to the pre-existing network. In the glomerular layer of the OB, there is a constant net addition of adult-generated neurons reaching a third of the total neuronal population within 9 months. In contrast, adult neurogenesis contributes to only a minor fraction of the entire neuronal network in the granular cell layer of the OB and the DG. Although the fraction of adult generated neurons can be further increased by an enriched environment, it still remains a minority of the neuronal network in the DG. Thus, neuron addition is distinct and tightly regulated in the neuronal networks that incorporate new neurons life long. | |||||
| 書誌情報 |
The Journal of Neuroscience en : The Journal of Neuroscience 巻 27, 号 40, p. 10906-10911, 発行日 2007-10-03 |
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| 雑誌内区分 | ||||||
| 値 | Brief Communications | |||||
| 出版者 | ||||||
| 出版者 | Society for Neuroscience | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 02706474 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10620404 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1523/JNEUROSCI.2572-07.2007 | |||||
| 権利 | ||||||
| 権利情報 | Copyright ©2007 Society for Neuroscience | |||||
| 情報源 | ||||||
| 関連名称 | Ninkovic, Jovica, Tetsuji Mori, and Magdalena Götz. "Distinct modes of neuron addition in adult mouse neurogenesis." Journal of Neuroscience 27.40 (2007): 10906-10911. | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jneurosci.org/content/27/40/10906 | |||||
| 関連名称 | https://www.jneurosci.org/content/27/40/10906 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
