| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-11-22 |
| タイトル |
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|
タイトル |
Development of a New Method for Simultaneous Quantitation of Plasma Concentrations of Voriconazole and Voriconazole N-Oxide Using Column-Switching LC-MS/MS and Its Application in Therapeutic Drug Monitoring |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題 |
liquid chromatography |
| キーワード |
|
|
言語 |
en |
|
主題 |
pharmacokinetics |
| キーワード |
|
|
言語 |
en |
|
主題 |
tandem mass spectrometry |
| キーワード |
|
|
言語 |
en |
|
主題 |
therapeutic drug monitoring |
| キーワード |
|
|
言語 |
en |
|
主題 |
voriconazole |
| 資源タイプ |
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|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
| 著者 |
Yamamoto,Tatsuro
Ishida,Masako
Kodama,Nao
Saiki,Yusuke
Fujiyoshi,Masachika
島田,美樹
|
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Pharmacy, Tottori University Hospital |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Pharmacy, Tottori University Hospital |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Pharmacy, Tottori University Hospital |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Pharmacy, Tottori University Hospital |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Pharmacy, Tottori University Hospital |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Pharmacy, Tottori University Hospital |
| 抄録 |
|
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内容記述タイプ |
Other |
|
内容記述 |
Background: Voriconazole therapy for fungal infections usually continues for several years and is often administered on an outpatient basis. Maintaining the voriconazole plasma concentration in the therapeutic range is highly important for effective therapy; however, it is difficult to obtain sufficient information to assess the voriconazole concentration in outpatients. Therefore, we developed a method to simultaneously measure the plasma concentrations of voriconazole and its major metabolite, voriconazole N-oxide, to obtain rapid results after outpatient blood collection and before medical consultation and to attain a better understanding of adherence and the drug-drug interactions of voriconazole. Methods: Fifty microliters of patient plasma was deproteinized with methanol, injected into the liquid chromatography-tandem mass spectrometry system, and purified using an online column. Separation was achieved on an InertSustain C18 column (2.1 mm id x 50 mm, 2 mu m) with a mobile phase of 30:70 (0.1% formic acid in water:methanol) at a flow rate of 0.2 mL/min. Detection was performed using electrospray ionization in positive ion multiple reaction monitoring mode. Results: The analysis time was 4 min. The calibration curve was linear, in the range of 0.1 mu g/mL to 20 mu g/mL for voriconazole and 0.05 mu g/mL to 10 mu g/mL for voriconazole N-oxide, with a coefficient of determination at R-2 > 0.999. Conclusion: There is no need to dilute the patient's plasma even if the concentration of voriconazole is near the upper limit of measurement. Furthermore, the short measurement-time could immediately inform physicians of the patient's voriconazole concentration during ambulatory medical care. Simultaneous measurement of voriconazole and voriconazole N-oxide may also be useful for the immediate adjustment of voriconazole dosage in outpatients and would help us to understand adherence or drug-drug interactions in plasma voriconazole concentrations. |
|
言語 |
en |
| 書誌情報 |
en : Yonago Acta Medica
巻 66,
号 3,
p. 365-374,
ページ数 10,
発行日 2023-08-25
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| 出版者 |
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|
出版者 |
Tottori University Medical Press |
|
言語 |
en |
| ISSN |
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|
収録物識別子タイプ |
PISSN |
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収録物識別子 |
13468049 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00892882 |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
(C)2023 Tottori University Medical Press |
| 情報源 |
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関連名称 |
Yonago Acta Medica. 2023, 66(3), 365-374. |
| 関連サイト |
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識別子タイプ |
URI |
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|
関連識別子 |
https://www.lib.tottori-u.ac.jp/yam/yam/yam66-3/66-3contents.html |
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|
関連名称 |
https://www.lib.tottori-u.ac.jp/yam/yam/yam66-3/66-3contents.html |
| 関連サイト |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.33160/yam.2023.08.009 |
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|
関連名称 |
https://doi.org/10.33160/yam.2023.08.009 |
| 著者版フラグ |
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出版タイプ |
VoR |
yam66(3)_365.pdf
