Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2024-03-21 |
タイトル |
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言語 |
en |
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タイトル |
Intra-Articular Injection of Chitin Nanofiber Attenuates Osteoarthritis: An Experimental Study in a Rat Model of Osteoarthritis |
言語 |
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言語 |
eng |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
chitin nanofibers |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
osteoarthritic rat model |
資源タイプ |
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資源タイプ |
journal article |
アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
著者 |
Okuno,Masayuki
榎田,誠
柳樂,慶太
永島,英樹
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著者所属(英) |
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en |
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Division of Orthopedic Surgery, Department of Sensory and Motor Organs, School of Medicine, Faculty of Medicine, Tottori University |
著者所属(英) |
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en |
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Division of Orthopedic Surgery, Department of Sensory and Motor Organs, School of Medicine, Faculty of Medicine, Tottori University |
著者所属(英) |
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en |
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Division of Orthopedic Surgery, Department of Sensory and Motor Organs, School of Medicine, Faculty of Medicine, Tottori University |
著者所属(英) |
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en |
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Division of Orthopedic Surgery, Department of Sensory and Motor Organs, School of Medicine, Faculty of Medicine, Tottori University |
抄録 |
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内容記述タイプ |
Other |
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内容記述 |
Background: This study aimed to evaluate the effect of chitin nanofibers (CNF) produced from crab shells as a medical material for the knee in an osteoarthritic rat model. Methods: The effect of intra-articular CNF injection was evaluated histologically among three groups: saline, hyaluronic acid (HA), and CNF injection groups. The Osteoarthritis Research Society International (OARSI) cartilage, subchondral bone, synovial, and meniscus scores were used for scoring. Results: At 4 weeks, the CNF group had significantly lower scores than the saline group. The Synovial score was lower in HA and CNF groups at 4 weeks than in the saline group. At 4 weeks post-treatment, the thickening of the subchondral bone plate and angiogenesis were significantly reduced in the CNF treatment group compared to those in the saline treatment group (P = 0.02). Conclusion: The anti-inflammatory effects of CNF on knee osteoarthritis were comparable to that of HA in the early stages. |
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言語 |
en |
書誌情報 |
en : Yonago Acta Medica
巻 67,
号 1,
p. 22-30,
ページ数 9,
発行日 2024-02-21
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出版者 |
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言語 |
en |
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出版者 |
Tottori University Medical Press |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
13468049 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00892882 |
権利 |
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言語 |
en |
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権利情報 |
(C)2024 Tottori University Medical Press |
情報源 |
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関連名称 |
Yonago Acta Medica. 2024, 67(1), 22-30. |
関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
https://www.lib.tottori-u.ac.jp/yam/yam/yam67-1/67-1contents.html |
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関連名称 |
https://www.lib.tottori-u.ac.jp/yam/yam/yam67-1/67-1contents.html |
関連サイト |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.33160/yam.2024.02.003 |
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関連名称 |
https://doi.org/10.33160/yam.2024.02.003 |
著者版フラグ |
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出版タイプ |
VoR |