| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-02-21 |
| タイトル |
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|
タイトル |
Comparison of the Survivals and Adverse Events for Localized High-Risk Prostate Cancer Treated with Intensity-Modulated Radiotherapy Plus Androgen Deprivation and Trimodality Therapy, Including Low-Dose Iodine-125 Brachytherapy and External Beam Radiotherapy Plus Androgen Deprivation |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
adverse events |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
I-125 brachytherapy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
intensity-modulated radiotherapy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
localized prostate cancer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
trimodality |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| アクセス権 |
|
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
北川,寛
吉田,賢史
竹内,有樹
Tanino,Tomohiko
坂口,弘美
清水,龍太郎
山口,徳也
森實,修一
武中,篤
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| 抄録 |
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内容記述タイプ |
Other |
|
内容記述 |
Background: To evaluate and compare the survivals and radiotherapy-induced adverse events (AEs) of intensity-modulated radiotherapy (IMRT) with androgen deprivation therapy (ADT) and trimodality therapy, including low-dose iodine-125 brachytherapy, external beam radiotherapy, and ADT, for high-risk localized prostate cancer (LPC). Methods: High-risk patients with LPC at T stage ≥ 3a,Gleason score ≥ 8, and initial prostate-specific antigen ≥20.0 ng/mL treated between 2010 and 2021 were retrospectively evaluated. All the patients were treated with IMRT plus ADT or trimodality therapy. In both groups, ADT was initiated 6 months before and continued for 2 years after radiotherapy. Survival and acute and late radiation-induced AEs were evaluated and compared. Results: Two hundred and thirty-eight patients were treated with IMRT, and 91 underwent trimodality. Five-and 7-year biochemical-clinical failure-free survival (BCFFS) rates in the IMRT/trimodality group were 94.9/96.2, and 91.8/91.5%, respectively (P = 0.511). Stratified by 1–2/3 factors, 5- and 7-year BCFFS rates in the IMRT groups were 95.8/91.8, and 95.8/75.6%,respectively (P = 0.009). Five and 7-year BCFFS rates in the trimodality group were 96.8/94.1, and 91.4/94.1%, respectively (P = 0.995). The cumulative 3-/5-year incidence of late genitourinary AEs in the IMRT/trimodality group was 7.3/8.4, and 15.5/16.9%, respectively(P = 0.037), and the cumulative 3-/5-year incidence of late gastrointestinal AEs was 2.2/3.4, and 11.0/12.2%, respectively (P = 0.001). Thirty patients (9.1%) could not complete long-term ADT. Conclusion: Treatment results of both IMRT and trimodality were considered to be good, and our results also indicated that the long-term survival of unfavorable high-risk patients with LPC who had three risk factors was poor in the IMRT group. Further treatment experience of both modalities must be accumulated with more appropriate patient allocations. |
|
言語 |
en |
| 書誌情報 |
en : Yonago Acta Medica
巻 68,
号 1,
p. 12-21,
ページ数 10,
発行日 2025-02-21
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| 出版者 |
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出版者 |
Tottori University Medical Press |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
05135710 |
| ISSN |
|
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収録物識別子タイプ |
EISSN |
|
収録物識別子 |
13468049 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00892882 |
| 権利 |
|
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言語 |
en |
|
権利情報 |
(C) 2025 Tottori University Medical Press |
| 情報源 |
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言語 |
en |
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関連名称 |
Yutaka Kitagawa, Kenji Yoshida, Yuuki Takeuchi, Tomohiko Tanino, Hiromi Sakaguchi, Ryutaro Shimizu, Noriya Yamaguchi, Shuichi Morizane, Atsushi Takenaka. Comparison of the Survivals and Adverse Events for Localized High-Risk Prostate Cancer Treated with Intensity-Modulated Radiotherapy Plus Androgen Deprivation and Trimodality Therapy, Including Low-Dose Iodine-125 Brachytherapy and External Beam Radiotherapy Plus Androgen Deprivation. Yonago Acta Medica, 2025, 68(1), 12-21, doi: https://doi.org/10.33160/yam.2025.02.002 |
| 関連サイト |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.33160/yam.2025.02.002 |
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関連名称 |
https://doi.org/10.33160/yam.2025.02.002 |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
https://www.lib.tottori-u.ac.jp/yam/yam/yam68-1/68-1contents.html |
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関連名称 |
https://www.lib.tottori-u.ac.jp/yam/yam/yam68-1/68-1contents.html |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
yam68(1)_12.pdf (1.5 MB)
