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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
  1. 資料タイプ一覧
  2. 紀要論文
  1. 鳥取大学の刊行物
  2. 米子医学雑誌
  3. 63
  4. 1

甲状腺腫蕩組織における転写抑制因子PLZFの発現パターンについての検討

https://repository.lib.tottori-u.ac.jp/records/4408
https://repository.lib.tottori-u.ac.jp/records/4408
5b4378a2-feab-4ae9-abd3-708363e6410d
名前 / ファイル ライセンス アクション
jyma63(1)_15.pdf jyma63(1)_15.pdf (775.6 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2018-06-22
タイトル
言語 ja
タイトル 甲状腺腫蕩組織における転写抑制因子PLZFの発現パターンについての検討
タイトル
言語 en
タイトル Transcriptional repressor PLZF is differentially expressed in thyroid neoplasm,reflecting the impairment of follicular formation
言語
言語 jpn
キーワード
主題 PLZF
キーワード
主題 thyroid neoplasm
キーワード
主題 tumorigenesis
キーワード
主題 folliculogenesis
キーワード
言語 en
主題 PLZF
キーワード
言語 en
主題 thyroid neoplasm
キーワード
言語 en
主題 tumorigenesis
キーワード
言語 en
主題 folliculogenesis
資源タイプ
資源タイプ departmental bulletin paper
タイトル(ヨミ)
その他のタイトル コウジョウセン シュヨウ ソシキ ニ オケル テンシャ ヨクセイ インシ PLZF ノ ハツゲン パターン ニ ツイテ ノ ケントウ
言語 ja-Kana
著者 松澤, 和彦

× 松澤, 和彦

WEKO 2090
研究者総覧鳥取大学 100000851

松澤, 和彦

ja-Kana マツザワ, カズヒコ

en Matsuzawa, Kazuhiko

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著者所属
鳥取大学医学部統合内科医学講座病態情報内科学分野(主任山本一博教授)
抄録
内容記述タイプ Other
内容記述 PLZF (Promyelocytic Leukemia Zn Finger) is a transcriptional repressor which is originally isolated from a patient with promyelocytic leukemia. Moreover, PLZF affects the key element of cell cycle progression such as cyclin A. So far, the functional role of PLZF in thyroid cells remains unclear. In this study, we analyzed the expression profile of PLZF in thyroid neoplasms. We estimated PLZF expression in normal thyroid (n=6), multinodular goiter (n=4), follicular adenoma (n=3), follicular carcinoma (n=1), papillary carcinoma (n=18) and anaplastic carcinoma (n=3). PLZF expression was estimated by immunohistochemical staining and western blotting. In all of papillary carcinoma, PLZF is expressed in cytosol with high intensity. In contrast, in normal thyroid, follicular adenoma and follicular carcinoma, P LZF is localized in nucleus. We speculate that the intracellular translocation of PLZF reflects the differentiation between benign and malignancy. Although follicular carcinoma is malignant tissue, its PLZF expression pattern was same as benign thyroid tissues. Then differentiation of PLZF expression in follicular carcinoma from papillary carcinoma and anaplastic carcinoma is due to retaining follicular structure. We presume that PLZF expression in nucleus could be related to the maintenance of follicular structure.
書誌情報 ja : 米子医学雑誌
en : The Journal of the Yonago Medical Association

巻 63, 号 1, p. 15-21, 発行日 2012-01-31
出版者
出版者 米子医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00440558
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00247383
権利
権利情報 注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.
情報源
関連名称 米子医学雑誌. 2012, 63(1), 15-21
著者版フラグ
出版タイプ VoR
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