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Development of a Prognostic Scoring System using MYC Expression and Soluble Interleukin Receptor -2 level for Diffuse Large B-cell Lymphoma
https://repository.lib.tottori-u.ac.jp/records/4609
https://repository.lib.tottori-u.ac.jp/records/46096beb8a81-101d-47fd-9254-1bdfc3bf285f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
yam66(1)_56.pdf (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2023-02-28 | |||||
| タイトル | ||||||
| タイトル | Development of a Prognostic Scoring System using MYC Expression and Soluble Interleukin Receptor -2 level for Diffuse Large B-cell Lymphoma | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | diffuse large B-cell lymphoma | |||||
| キーワード | ||||||
| 主題 | not otherwise specified | |||||
| キーワード | ||||||
| 主題 | immunohistochemistry | |||||
| キーワード | ||||||
| 主題 | MYC | |||||
| キーワード | ||||||
| 主題 | Proto-Oncogene Proteins | |||||
| キーワード | ||||||
| 主題 | non-Hodgkin lymphoma | |||||
| キーワード | ||||||
| 主題 | R-CHOP chemotherapy | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | diffuse large B-cell lymphoma | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | not otherwise specified | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | immunohistochemistry | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | MYC | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Proto-Oncogene Proteins | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | non-Hodgkin lymphoma | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | R-CHOP chemotherapy | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
桑本, 聡史
× 桑本, 聡史× 河村, 浩二× 松下, 倫子× 本倉, 徹× 細田, 譲× 梅北, 善久× 福田, 哲也× Suzuki, Sayaka× Maegaki, Masaya× Hosoda, Rina× Hara, Kentaro |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Hematology, Tottori University Hospital / Division of Clinical Laboratory Medicine, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Pathology, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Hematology, Tottori University Hospital / Division of Clinical Laboratory Medicine, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Pathobiological Science and Technology, School of Health Science, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Clinical Laboratory Medicine, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Hematology, Tottori University Hospital / Division of Clinical Laboratory Medicine, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Hematology, Tottori University Hospital | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Hematology, Tottori University Hospital | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Hematology, Tottori University Hospital | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Pathology, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Hematology, Tottori University Hospital | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Background: Diffuse large B-cell lymphoma, not otherwise specified (DLBCL-NOS), is the most frequent type of lymphoid neoplasm. Methods: We investigated the relationships between clinical factors of DLBCL-NOS and MYC immunohistochemistry (IHC) staining. Results: A total of 110 patients diagnosed with DLBCL-NOS from 2012 to 2020 at Tottori University Hospital and treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) chemotherapy were included. IHC staining of MYC in formalin-fixed, paraffin-embedded tumor specimens was performed, and ROC-curve analysis revealed the cut-off value of the MYC positive rate as 55%. The 2-year overall survival (OS) rates of the MYC-negative and -positive groups were 84.7% vs 57.7% (P = 0.0091), and the progression-free survival rates were 77.8% vs 54.7% (P = 0.016), respectively. Multivariate analysis for OS showed prognostic significance of MYC positivity [hazards ratio (HR): 2.496; P = 0.032], and serum levels of soluble interleukin-2 receptor (sIL-2R) > 2000 U/mL (HR: 3.950; P = 0.0019), as well as age > 75 (HR: 2.356; P = 0.068). The original scoring system was developed based on these findings. By assigning one point to each item, age (> 75), MYC positivity, and sIL-2R level (> 2000), all patients were classified into three risk categories: group 1 (0 points), group 2 (1 point), and group 3 (2–3 points). The 2-year survival rates were 100%, 83.0%, and 47.1% for the groups 1, 2, and 3, respectively (P < 0.0001). Conclusion: We suggest that a prognostic scoring system using MYC expression and soluble interleukin receptor -2 level is useful for the prediction of prognosis, contributing to further stratification in DLBCL-NOS. | |||||
| 書誌情報 |
Yonago Acta Medica en : Yonago Acta Medica 巻 66, 号 1, p. 56-66, 発行日 2023-02-20 |
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| 出版者 | ||||||
| 出版者 | Tottori University Medical Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05135710 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.33160/yam.2023.02.007 | |||||
| 権利 | ||||||
| 権利情報 | (C) 2023 Tottori University Medical Press. | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta Medica. 2023, 66(1), 56-66. doi:10.33160/yam.2023.02.007 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.lib.tottori-u.ac.jp/yam/yam/yam66-1/66-1contents.html | |||||
| 関連名称 | https://www.lib.tottori-u.ac.jp/yam/yam/yam66-1/66-1contents.html | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.33160/yam.2023.02.007 | |||||
| 関連名称 | https://doi.org/10.33160/yam.2023.02.007 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| EISSN | ||||||
| 値 | 13468049 | |||||
