| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-02-28 |
| タイトル |
|
|
タイトル |
Development of a Prognostic Scoring System using MYC Expression and Soluble Interleukin Receptor -2 level for Diffuse Large B-cell Lymphoma |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
diffuse large B-cell lymphoma |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
not otherwise specified |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
immunohistochemistry |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
MYC |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Proto-Oncogene Proteins |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
non-Hodgkin lymphoma |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
R-CHOP chemotherapy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
diffuse large B-cell lymphoma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
not otherwise specified |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
immunohistochemistry |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
MYC |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Proto-Oncogene Proteins |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
non-Hodgkin lymphoma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
R-CHOP chemotherapy |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
桑本, 聡史
河村, 浩二
松下, 倫子
本倉, 徹
細田, 譲
梅北, 善久
福田, 哲也
Suzuki, Sayaka
Maegaki, Masaya
Hosoda, Rina
Hara, Kentaro
|
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Hematology, Tottori University Hospital / Division of Clinical Laboratory Medicine, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Pathology, School of Medicine, Faculty of Medicine, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Hematology, Tottori University Hospital / Division of Clinical Laboratory Medicine, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Pathobiological Science and Technology, School of Health Science, Faculty of Medicine, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Clinical Laboratory Medicine, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Hematology, Tottori University Hospital / Division of Clinical Laboratory Medicine, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Hematology, Tottori University Hospital |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Hematology, Tottori University Hospital |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Hematology, Tottori University Hospital |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Pathology, School of Medicine, Faculty of Medicine, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Hematology, Tottori University Hospital |
| 抄録 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Background: Diffuse large B-cell lymphoma, not otherwise specified (DLBCL-NOS), is the most frequent type of lymphoid neoplasm. Methods: We investigated the relationships between clinical factors of DLBCL-NOS and MYC immunohistochemistry (IHC) staining. Results: A total of 110 patients diagnosed with DLBCL-NOS from 2012 to 2020 at Tottori University Hospital and treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) chemotherapy were included. IHC staining of MYC in formalin-fixed, paraffin-embedded tumor specimens was performed, and ROC-curve analysis revealed the cut-off value of the MYC positive rate as 55%. The 2-year overall survival (OS) rates of the MYC-negative and -positive groups were 84.7% vs 57.7% (P = 0.0091), and the progression-free survival rates were 77.8% vs 54.7% (P = 0.016), respectively. Multivariate analysis for OS showed prognostic significance of MYC positivity [hazards ratio (HR): 2.496; P = 0.032], and serum levels of soluble interleukin-2 receptor (sIL-2R) > 2000 U/mL (HR: 3.950; P = 0.0019), as well as age > 75 (HR: 2.356; P = 0.068). The original scoring system was developed based on these findings. By assigning one point to each item, age (> 75), MYC positivity, and sIL-2R level (> 2000), all patients were classified into three risk categories: group 1 (0 points), group 2 (1 point), and group 3 (2–3 points). The 2-year survival rates were 100%, 83.0%, and 47.1% for the groups 1, 2, and 3, respectively (P < 0.0001). Conclusion: We suggest that a prognostic scoring system using MYC expression and soluble interleukin receptor -2 level is useful for the prediction of prognosis, contributing to further stratification in DLBCL-NOS. |
| 書誌情報 |
Yonago Acta Medica
en : Yonago Acta Medica
巻 66,
号 1,
p. 56-66,
発行日 2023-02-20
|
| 出版者 |
|
|
出版者 |
Tottori University Medical Press |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
05135710 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00892882 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.33160/yam.2023.02.007 |
| 権利 |
|
|
権利情報 |
(C) 2023 Tottori University Medical Press. |
| 情報源 |
|
|
|
関連名称 |
Yonago Acta Medica. 2023, 66(1), 56-66. doi:10.33160/yam.2023.02.007 |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.lib.tottori-u.ac.jp/yam/yam/yam66-1/66-1contents.html |
|
|
関連名称 |
https://www.lib.tottori-u.ac.jp/yam/yam/yam66-1/66-1contents.html |
| 関連サイト |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.33160/yam.2023.02.007 |
|
|
関連名称 |
https://doi.org/10.33160/yam.2023.02.007 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
| EISSN |
|
|
値 |
13468049 |
yam66(1)_56.pdf (1.3 MB)
