WEKO3
アイテム
Cisplatin Induces Cell Death in Rat Adult Kidney Stem/ Progenitor Cell-Derived Kidney Organoids
https://repository.lib.tottori-u.ac.jp/records/4619
https://repository.lib.tottori-u.ac.jp/records/46192f9887d3-62f1-4559-8d8d-b0d184e198d5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
yam66(1)_153.pdf (2.3 MB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2023-02-28 | |||||
| タイトル | ||||||
| タイトル | Cisplatin Induces Cell Death in Rat Adult Kidney Stem/ Progenitor Cell-Derived Kidney Organoids | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | cell death | |||||
| キーワード | ||||||
| 主題 | cisplatin | |||||
| キーワード | ||||||
| 主題 | kidney organoids | |||||
| キーワード | ||||||
| 主題 | stem cells | |||||
| キーワード | ||||||
| 主題 | three-dimensional culture | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | cell death | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | cisplatin | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | kidney organoids | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | stem cells | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | three-dimensional culture | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Kuromi, Yasushi
× Kuromi, Yasushi× Endo, Takeshi× 古倉, 健嗣× 大林, 徹也× Kuromi, Yasushi× Kitamura, Shinji× Endo, Takeshi× Ueno, Shota |
|||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Research Facility, Advanced Medicine & Translational Research Center, Organization for Research Initiative and Promotion, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Research Facility, Advanced Medicine & Translational Research Center, Organization for Research Initiative and Promotion, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Research Facility, Advanced Medicine & Translational Research Center, Organization for Research Initiative and Promotion, Tottori University / Research and Development Division, Kikkoman Corporation | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Biomolecular Science, Faculty of Science, Toho University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Research Facility, Advanced Medicine & Translational Research Center, Organization for Research Initiative and Promotion, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Background: The use of stem/ progenitor cell-derived organoids to evaluate the toxicity of chemical substances has widely increased. Organoids with nephron-like structures (NLS) can be derived from rat adult kidney stem/ progenitor cells (rKS cells) using three-dimensional culture. In this study, we examined the effects of cisplatin, an anticancer drug that induces nephrotoxicity in vivo, on rKS cell-derived NLS. Methods: Twelve organoids were simultaneously derived from three-dimensionally cultured rKS cells in Matrigel matrices. The surface area of each organoid was measured using microscopy-based imaging, and the morphological changes of NLS were monitored using an image analysis method. NLS were exposed to cisplatin, and their associated effects were assessed. Results: NLS elongated over time. The surface areas of the 12 organoids were almost constant. Cisplatin exposure induced cell death in NLS and inhibited the increase in the surface area of the organoids. Conclusion: Cisplatin exposure induces damage to NLS derived from rKS cells. Thus, the organoids may be valuable as an in vitro model to assess nephrotoxicity. | |||||
| 書誌情報 |
Yonago Acta Medica en : Yonago Acta Medica 巻 66, 号 1, p. 153-158, 発行日 2023-02-20 |
|||||
| 出版者 | ||||||
| 出版者 | Tottori University Medical Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05135710 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.33160/yam.2023.02.018 | |||||
| 権利 | ||||||
| 権利情報 | (C) 2023 Tottori University Medical Press. | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta Medica. 2023, 66(1), 153-158. doi:10.33160/yam.2023.02.018 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.lib.tottori-u.ac.jp/yam/yam/yam66-1/66-1contents.html | |||||
| 関連名称 | https://www.lib.tottori-u.ac.jp/yam/yam/yam66-1/66-1contents.html | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.33160/yam.2023.02.018 | |||||
| 関連名称 | https://doi.org/10.33160/yam.2023.02.018 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| EISSN | ||||||
| 値 | 13468049 | |||||
