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Clinical Significance of Serum Antithrombin III Activity After Hepatectomy for Hepatocellular Carcinoma
https://repository.lib.tottori-u.ac.jp/records/4686
https://repository.lib.tottori-u.ac.jp/records/46865604b91e-2d99-4777-8d62-38cd52873936
| 名前 / ファイル | ライセンス | アクション |
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yam64(2)_168.pdf (767.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2021-06-30 | |||||
| タイトル | ||||||
| タイトル | Clinical Significance of Serum Antithrombin III Activity After Hepatectomy for Hepatocellular Carcinoma | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Antithrombin III | |||||
| キーワード | ||||||
| 主題 | Hepatectomy | |||||
| キーワード | ||||||
| 主題 | Hepatocellular carcinoma | |||||
| キーワード | ||||||
| 主題 | Prognostic factor | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Antithrombin III | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Hepatectomy | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Hepatocellular carcinoma | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Prognostic factor | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
徳安, 成郎
× 徳安, 成郎× 網崎, 正孝× 花木, 武彦× 村上, 裕樹× 森本, 昌樹× Yagyu, Takuki× Goto, Keisuke× 松永, 知之× 山本, 学× 高野, 周一× 坂本, 照尚× 本城, 総一郎× 藤原, 義之× Hanaki, Takehiko× Uchinaka, Ei× Yagyu, Takuki× Goto, Keisuke× Hasegawa, Toshimichi |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | [Background] As antithrombin III (AT-III) is produced in the hepatocytes, its serum activity decreases at the time of liver failure, in addition to ischemia reperfusion injury, vascular endothelial dysfunction, and disseminated intravascular coagulation (DIC). Here, we examined whether the serum AT-III value after hepatectomy could be a prognostic factor for hepatocellular carcinoma (HCC). [Methods] Of 141 patients who underwent hepatectomy for HCC, data for 101 patients in whom serum AT-III activity was measured on the first postoperative day were extracted. Patients with serum AT-III activity > 50% and ? 50% were assigned to high value (72 cases) and low value (29 cases) groups, respectively. We examined the clinical and prognostic differences between these two groups. [Results] The average age of enrolled patients (83 men and 18 women) was 68.0 years. The 5-year overall survival rate was 88% and 60% in the high and low value groups, respectively (P < 0.01). Furthermore, the 2-year relapse-free survival rate was 71% and 54% in the high and low value groups, respectively (P = 0.03). [Conclusion] This is the first study to demonstrate that serum AT-III levels on the first postoperative day may serve as a prognostic factor in HCC patients. | |||||
| 書誌情報 |
Yonago Acta Medica en : Yonago Acta Medica 巻 64, 号 2, p. 168-175, 発行日 2021-05-20 |
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| 出版者 | ||||||
| 出版者 | Tottori University Medical Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05135710 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.33160/yam.2021.05.007 | |||||
| 権利 | ||||||
| 権利情報 | (C) 2021 Tottori University Medical Press | |||||
| 情報源 | ||||||
| 関連名称 | Tokuyasu Naruo, Amisaki Masataka, Hanaki Takehiko, et al. Clinical Significance of Serum Antithrombin III Activity After Hepatectomy for Hepatocellular Carcinoma. Yonago Acta Medica. 2021, 64(2), 168-175. doi:10.33160/yam.2021.05.007 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.lib.tottori-u.ac.jp/yam/yam/yam64-2/64-2contents.html | |||||
| 関連名称 | http://www.lib.tottori-u.ac.jp/yam/yam/yam64-2/64-2contents.html | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/yam/64/2/64_2021.05.007/_article | |||||
| 関連名称 | https://www.jstage.jst.go.jp/article/yam/64/2/64_2021.05.007/_article | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| EISSN | ||||||
| 値 | 13468049 | |||||
