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Regulatory Mechanism of SNAP23 in Phagosome Formation and Maturation
https://repository.lib.tottori-u.ac.jp/records/4730
https://repository.lib.tottori-u.ac.jp/records/473057f4e25a-bbcf-498c-aad6-232a70c6af3c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
yam63(3)_135.pdf (1.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2020-10-26 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Regulatory Mechanism of SNAP23 in Phagosome Formation and Maturation | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | MAP1LC3A | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | membrane fusion | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | phagocytosis | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | SNAP23 protein | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | SNARE proteins | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | MAP1LC3A | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | membrane fusion | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | phagocytosis | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | SNAP23 protein | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | SNARE proteins | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 著者 |
初沢, 清隆
× 初沢, 清隆
WEKO
4750
× 櫻井, 千恵 |
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| 著者所属（英） | ||||||||||||
| 言語 | en | |||||||||||
| 値 | Division of Molecular Biology, School of Life Sciences, Faculty of Medicine, Tottori University | |||||||||||
| 著者所属（英） | ||||||||||||
| 言語 | en | |||||||||||
| 値 | Division of Molecular Biology, School of Life Sciences, Faculty of Medicine, Tottori University | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | Synaptosomal associated protein of 23 kDa (SNAP23), a plasma membrane-localized soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE), is a ubiquitously expressed protein that is generally involved in fusion of the plasma membrane and secretory or endosomal recycling vesicles during several types of exocytosis. SNAP23 is expressed in phagocytes, such as neutrophils, macrophages, and dendritic cells, and functions in both exocytosis and phagocytosis. This review focuses on the function of SNAP23 in immunoglobulin G Fc receptor-mediated phagocytosis by macrophages. SNAP23 and its partner SNAREs mediate fusion of the plasma membrane with intracellular organelles or vesicles to form phagosomes as well as the fusion of phagosomes with endosomes or lysosomes to induce phagosome maturation, characterized by reactive oxygen species production and acidification. During these processes, SNAP23 function is regulated by phosphorylation. In addition, microtubule-associated protein 1A/1B light chain 3 (LC3)-associated phagocytosis, which tightly promotes or suppresses phagosome maturation depending on the foreign target, requires SNAP23 function. SNAP23 that is enriched on the phagosome membrane during LC3-associated phagocytosis may be phosphorylated or dephosphorylated, thereby enhancing or inhibiting subsequent phagosome maturation, respectively. These findings have increased our understanding of the SNAP23-associated membrane trafficking mechanism in phagocytes, which has important implications for microbial pathogenesis and innate and adaptive immune responses. | |||||||||||
| 書誌情報 |
Yonago Acta Medica en : Yonago Acta Medica 巻 63, 号 3, p. 135-145, 発行日 2020-08-20 |
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| 雑誌内区分 | ||||||||||||
| 値 | Review Articles: Special Contribution | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | Tottori University Medical Press | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 05135710 | |||||||||||
| 書誌レコードID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA00892882 | |||||||||||
| DOI | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.33160/yam.2020.08.001 | |||||||||||
| 権利 | ||||||||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||||||||
| 情報源 | ||||||||||||
| 関連名称 | Hatsuzawa Kiyotaka, Sakurai Chiye. Regulatory Mechanism of SNAP23 in Phagosome Formation and Maturation. Yonago Acta Medica. 2020, 63(3). 135-145. doi: 10.33160/yam.2020.08.001. | |||||||||||
| 関連サイト | ||||||||||||
| 識別子タイプ | URI | |||||||||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/yam/63/3/63_2020.08.001/_article/ | |||||||||||
| 関連名称 | https://www.jstage.jst.go.jp/article/yam/63/3/63_2020.08.001/_article/ | |||||||||||
| 関連サイト | ||||||||||||
| 識別子タイプ | URI | |||||||||||
| 関連識別子 | http://www.lib.tottori-u.ac.jp/yam/yam/yam63-3/63-3contents.html | |||||||||||
| 関連名称 | http://www.lib.tottori-u.ac.jp/yam/yam/yam63-3/63-3contents.html | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| EISSN | ||||||||||||
| 値 | 1346-8049 | |||||||||||
