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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
  1. 資料タイプ一覧
  2. 学術雑誌論文
  1. 鳥取大学の刊行物
  2. Yonago Acta Medica
  3. 62
  4. 1

Possible Relationship Between MYBL1 Alterations and Specific Primary Sites in Adenoid Cystic Carcinoma: A Clinicopathological and Molecular Study of 36 Cases

https://repository.lib.tottori-u.ac.jp/records/4771
https://repository.lib.tottori-u.ac.jp/records/4771
bc806ccd-6183-4eba-ac83-31ca243d8def
名前 / ファイル ライセンス アクション
yam62(1)_67.pdf yam62(1)_67.pdf (2.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-06-17
タイトル
タイトル Possible Relationship Between MYBL1 Alterations and Specific Primary Sites in Adenoid Cystic Carcinoma: A Clinicopathological and Molecular Study of 36 Cases
言語 en
言語
言語 eng
キーワード
主題 adenoid cystic carcinoma
キーワード
主題 fluorescence in-situ hybridization
キーワード
主題 mandibular neoplasms
キーワード
主題 oncogene fusion
キーワード
主題 prognosis
キーワード
言語 en
主題 adenoid cystic carcinoma
キーワード
言語 en
主題 fluorescence in-situ hybridization
キーワード
言語 en
主題 mandibular neoplasms
キーワード
言語 en
主題 oncogene fusion
キーワード
言語 en
主題 prognosis
資源タイプ
資源タイプ journal article
著者 Endo, Yukari

× Endo, Yukari

WEKO 17090

Endo, Yukari
ja-Kana エンドウ, ユカリ
Search repository
Kuwamoto, Satoshi

× Kuwamoto, Satoshi

WEKO 1855
e-Rad 60567189
研究者総覧鳥取大学 100000360

Kuwamoto, Satoshi
ja-Kana クワモト, サトシ
en Kuwamoto, Satoshi
Search repository
Ohira, Takahito

× Ohira, Takahito

WEKO 2784
e-Rad 60757665
研究者総覧鳥取大学 100001509

Ohira, Takahito
ja-Kana オオヒラ, タカヒト
en Ohira, Takahito
Search repository
Matsushita, Michiko

× Matsushita, Michiko

WEKO 2075
e-Rad 70642198
研究者総覧鳥取大学 100000920

Matsushita, Michiko
ja-Kana マツシタ, ミチコ
en Matsushita, Michiko
Search repository
Matsushige, Takahiro

× Matsushige, Takahiro

WEKO 17091

Matsushige, Takahiro
Search repository
Fukuhara, Takahiro

× Fukuhara, Takahiro

WEKO 405
e-Rad 80403418
研究者総覧鳥取大学 100001318

Fukuhara, Takahiro
ja-Kana フクハラ, タカヒロ
en Fukuhara, Takahiro
Search repository
Nakamoto, Shu

× Nakamoto, Shu

WEKO 17092

Nakamoto, Shu
Search repository
Hayashi, Kazuhiko

× Hayashi, Kazuhiko

WEKO 660
e-Rad 30180962
研究者総覧鳥取大学 100000220

Hayashi, Kazuhiko
ja-Kana ハヤシ, カズヒコ
en Hayashi, Kazuhiko
Search repository
Kugoh, Hiroyuki

× Kugoh, Hiroyuki

WEKO 1772
e-Rad 40225131
研究者総覧鳥取大学 100000300

Kugoh, Hiroyuki
ja-Kana クゴウ, ヒロユキ
en Kugoh, Hiroyuki
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Hirooka, Yasuaki

× Hirooka, Yasuaki

WEKO 17093

Hirooka, Yasuaki
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Endo, Yukari

× Endo, Yukari

WEKO 17094

en Endo, Yukari
ja-Kana エンドウ, ユカリ
Search repository
Matsushige, Takahiro

× Matsushige, Takahiro

WEKO 17095

en Matsushige, Takahiro
Search repository
Nakamoto, Shu

× Nakamoto, Shu

WEKO 17096

en Nakamoto, Shu
Search repository
Hirooka, Yasuaki

× Hirooka, Yasuaki

WEKO 17097

en Hirooka, Yasuaki
Search repository
著者所属
値 Department of Pathology, Tottori University Hospital/Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine
著者所属
値 Department of Pathology, Tottori University Hospital
著者所属
値 Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University
著者所属
値 Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine
著者所属
値 Department of Pathology, Tottori University Hospital
著者所属
値 Division of Otolaryngology, Head and Neck Surgery, Department of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Department of Pathology, Tottori Prefectural Central Hospital
著者所属
値 Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University
著者所属
値 Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine
著者所属（英）
言語 en
値 Department of Pathology, Tottori University Hospital/Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine
著者所属（英）
言語 en
値 Department of Pathology, Tottori University Hospital
著者所属（英）
言語 en
値 Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University
著者所属（英）
言語 en
値 Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine
著者所属（英）
言語 en
値 Department of Pathology, Tottori University Hospital
著者所属（英）
言語 en
値 Division of Otolaryngology, Head and Neck Surgery, Department of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine
著者所属（英）
言語 en
値 Department of Pathology, Tottori Prefectural Central Hospital
著者所属（英）
言語 en
値 Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine
著者所属（英）
言語 en
値 Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University
著者所属（英）
言語 en
値 Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine
抄録
内容記述タイプ Other
内容記述 [Background] Adenoid cystic carcinoma (ACC) is a relatively rare malignant neoplasm that occurs in salivary glands and various other organs. Recent studies have revealed that a significant proportion of ACCs harbor gene alterations involving MYB or MYBL1 (mostly fusions with NFIB) in a mutually-exclusive manner. However, its clinical significance remains to be well-established. [Methods] We investigated clinicopathological and molecular features of 36 ACCs with special emphasis on the significance of MYBL1 alterations. Reverse-transcription polymerase-chain reaction (RT-PCR) and fluorescence in-situ hybridization (FISH) were performed to detect MYB/MYBL1-NFIB fusions and MYBL1 alterations, respectively. Immunohistochemistry was performed to evaluate MYB expression in the tumors. The results were correlated with clinicopathological profiles of the patients. [Results] RT-PCR revealed MYB-NFIB and MYBL1-NFIB fusions in 10 (27.8%) and 7 (19.4%) ACCs, respectively, in a mutually-exclusive manner. FISH for MYBL1 rearrangements was successfully performed in 11 cases, and the results were concordant with those of RT-PCR. Immunohistochemically, strong MYB expression was observed in 23 (63.9%) tumors, none of which showed MYBL1 alterations. Clinicopathologically, a trend of a better disease-specific survival was noted in patients with MYBL1 alterations than in those with MYB-NFIB fusions and/or strong MYB expression; however, the difference was not significant. Interestingly, we found tumors with MYBL1 alterations significantly frequently occurred in the mandibular regions (P = 0.012). Moreover, literature review revealed a similar tendency in a previous study. [Conclusion] Our results suggest that there are some biological or etiological differences between ACCs with MYB and MYBL1 alterations. Moreover, the frequent occurrence of MYBL1-associated ACC in the mandibular regions suggests that MYB immunohistochemistry is less useful in diagnosing ACCs arising in these regions. Further studies are warranted to verify our findings.
書誌情報 Yonago Acta Medica
en : Yonago Acta Medica

巻 62, 号 1, p. 67-76, 発行日 2019-03-28
出版者
出版者 Tottori University Medical Press
ISSN
収録物識別子タイプ ISSN
収録物識別子 05135710
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00892882
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.33160/yam.2019.03.010
権利
権利情報 Yonago Acta medica　編集委員会
情報源
関連名称 Yonago Acta Medica. 2019, 62(1), 67-76
関連サイト
識別子タイプ URI
関連識別子 https://www.jstage.jst.go.jp/article/yam/62/1/62_2019.03.010/_article/-char/en
関連名称 https://www.jstage.jst.go.jp/article/yam/62/1/62_2019.03.010/_article/-char/en
関連サイト
識別子タイプ URI
関連識別子 http://www.lib.tottori-u.ac.jp/yam/yam/yam62-1/62-1contents.html
関連名称 http://www.lib.tottori-u.ac.jp/yam/yam/yam62-1/62-1contents.html
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
EISSN
値 1346-8049
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