{"_buckets": {"deposit": "ba5e1315-4784-49f3-b87a-8ab7317c0a7c"}, "_deposit": {"created_by": 10, "id": "4771", "owners": [10], "pid": {"revision_id": 0, "type": "depid", "value": "4771"}, "status": "published"}, "_oai": {"id": "oai:repository.lib.tottori-u.ac.jp:00004771", "sets": ["12", "9", "994"]}, "author_link": ["17090", "1855", "2784", "2075", "17091", "405", "17092", "660", "1772", "17093", "17094", "17095", "17096", "17097"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-03-28", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "76", "bibliographicPageStart": "67", "bibliographicVolumeNumber": "62", "bibliographic_titles": [{"bibliographic_title": "Yonago Acta Medica"}, {"bibliographic_title": "Yonago Acta Medica", "bibliographic_titleLang": "en"}]}]}, "item_10001_checkbox_27": {"attribute_name": "部局名", "attribute_value_mlt": [{"subitem_checkbox_item": ["i-gakubu"]}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "[Background] Adenoid cystic carcinoma (ACC) is a relatively rare malignant neoplasm that occurs in salivary glands and various other organs. Recent studies have revealed that a significant proportion of ACCs harbor gene alterations involving MYB or MYBL1 (mostly fusions with NFIB) in a mutually-exclusive manner. However, its clinical significance remains to be well-established. [Methods] We investigated clinicopathological and molecular features of 36 ACCs with special emphasis on the significance of MYBL1 alterations. Reverse-transcription polymerase-chain reaction (RT-PCR) and fluorescence in-situ hybridization (FISH) were performed to detect MYB/MYBL1-NFIB fusions and MYBL1 alterations, respectively. Immunohistochemistry was performed to evaluate MYB expression in the tumors. The results were correlated with clinicopathological profiles of the patients. [Results] RT-PCR revealed MYB-NFIB and MYBL1-NFIB fusions in 10 (27.8%) and 7 (19.4%) ACCs, respectively, in a mutually-exclusive manner. FISH for MYBL1 rearrangements was successfully performed in 11 cases, and the results were concordant with those of RT-PCR. Immunohistochemically, strong MYB expression was observed in 23 (63.9%) tumors, none of which showed MYBL1 alterations. Clinicopathologically, a trend of a better disease-specific survival was noted in patients with MYBL1 alterations than in those with MYB-NFIB fusions and/or strong MYB expression; however, the difference was not significant. Interestingly, we found tumors with MYBL1 alterations significantly frequently occurred in the mandibular regions (P = 0.012). Moreover, literature review revealed a similar tendency in a previous study. [Conclusion] Our results suggest that there are some biological or etiological differences between ACCs with MYB and MYBL1 alterations. Moreover, the frequent occurrence of MYBL1-associated ACC in the mandibular regions suggests that MYB immunohistochemistry is less useful in diagnosing ACCs arising in these regions. Further studies are warranted to verify our findings.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Tottori University Medical Press"}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.33160/yam.2019.03.010", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_16": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "Yonago Acta Medica. 2019, 62(1), 67-76"}]}]}, "item_10001_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://www.jstage.jst.go.jp/article/yam/62/1/62_2019.03.010/_article/-char/en"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.jstage.jst.go.jp/article/yam/62/1/62_2019.03.010/_article/-char/en", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "http://www.lib.tottori-u.ac.jp/yam/yam/yam62-1/62-1contents.html"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.lib.tottori-u.ac.jp/yam/yam/yam62-1/62-1contents.html", "subitem_relation_type_select": "URI"}}]}, "item_10001_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Yonago Acta medica　編集委員会"}]}, "item_10001_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00892882", "subitem_source_identifier_type": "NCID"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05135710", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_text_25": {"attribute_name": "EARMAS ID", "attribute_value_mlt": [{"subitem_text_value": "6299"}]}, "item_10001_text_26": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_text_value": "1346-8049"}]}, "item_10001_text_29": {"attribute_name": "最新掲載誌名", "attribute_value_mlt": [{"subitem_text_value": "yam;Yonago Acta medica;Yonago Acta medica"}]}, "item_10001_text_32": {"attribute_name": "著者所属", "attribute_value_mlt": [{"subitem_text_value": "Department of Pathology, Tottori University Hospital/Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine"}, {"subitem_text_value": "Department of Pathology, Tottori University Hospital"}, {"subitem_text_value": "Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University"}, {"subitem_text_value": "Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine"}, {"subitem_text_value": "Department of Pathology, Tottori University Hospital"}, {"subitem_text_value": "Division of Otolaryngology, Head and Neck Surgery, Department of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine"}, {"subitem_text_value": "Department of Pathology, Tottori Prefectural Central Hospital"}, {"subitem_text_value": "Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine"}, {"subitem_text_value": "Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University"}, {"subitem_text_value": "Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine"}]}, "item_10001_text_33": {"attribute_name": "著者所属（英）", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Pathology, Tottori University Hospital/Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pathology, Tottori University Hospital"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pathology, Tottori University Hospital"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Otolaryngology, Head and Neck Surgery, Department of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pathology, Tottori Prefectural Central Hospital"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Endo, Yukari"}, {"creatorName": "エンドウ, ユカリ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": 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"nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsushige, Takahiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "17095", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamoto, Shu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "17096", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirooka, Yasuaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "17097", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-05-22"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "yam62(1)_67.pdf", "filesize": [{"value": "2.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Yonago Acta medica　編集委員会", "licensetype": "license_note", "mimetype": "application/pdf", "size": 2100000.0, "url": {"label": "yam62(1)_67.pdf", "url": "https://repository.lib.tottori-u.ac.jp/record/4771/files/yam62(1)_67.pdf"}, "version_id": "cc2c6f55-8ceb-45e9-9b6c-8756be35b83b"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "adenoid cystic carcinoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "fluorescence in-situ hybridization", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mandibular neoplasms", "subitem_subject_scheme": "Other"}, {"subitem_subject": "oncogene fusion", "subitem_subject_scheme": "Other"}, {"subitem_subject": "prognosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "adenoid cystic carcinoma", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "fluorescence in-situ hybridization", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mandibular neoplasms", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "oncogene fusion", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "prognosis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Possible Relationship Between MYBL1 Alterations and Specific Primary Sites in Adenoid Cystic Carcinoma: A Clinicopathological and Molecular Study of 36 Cases", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Possible Relationship Between MYBL1 Alterations and Specific Primary Sites in Adenoid Cystic Carcinoma: A Clinicopathological and Molecular Study of 36 Cases", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "10", "path": ["12", "9", "994"], "permalink_uri": "https://repository.lib.tottori-u.ac.jp/records/4771", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2019-06-17"}, "publish_date": "2019-06-17", "publish_status": "0", "recid": "4771", "relation": {}, "relation_version_is_last": true, "title": ["Possible Relationship Between MYBL1 Alterations and Specific Primary Sites in Adenoid Cystic Carcinoma: A Clinicopathological and Molecular Study of 36 Cases"], "weko_shared_id": -1}