| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-06-17 |
| タイトル |
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|
言語 |
en |
|
タイトル |
Possible Relationship Between MYBL1 Alterations and Specific Primary Sites in Adenoid Cystic Carcinoma: A Clinicopathological and Molecular Study of 36 Cases |
| 言語 |
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|
言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
主題 |
adenoid cystic carcinoma |
| キーワード |
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主題Scheme |
Other |
|
主題 |
fluorescence in-situ hybridization |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
mandibular neoplasms |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
oncogene fusion |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
prognosis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
adenoid cystic carcinoma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
fluorescence in-situ hybridization |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
mandibular neoplasms |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
oncogene fusion |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
prognosis |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
Endo, Yukari
Kuwamoto, Satoshi
Ohira, Takahito
Matsushita, Michiko
Matsushige, Takahiro
Fukuhara, Takahiro
Nakamoto, Shu
Hayashi, Kazuhiko
Kugoh, Hiroyuki
Hirooka, Yasuaki
Endo, Yukari
Matsushige, Takahiro
Nakamoto, Shu
Hirooka, Yasuaki
|
| 著者所属 |
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Department of Pathology, Tottori University Hospital/Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine |
| 著者所属 |
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Department of Pathology, Tottori University Hospital |
| 著者所属 |
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Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University |
| 著者所属 |
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Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine |
| 著者所属 |
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Department of Pathology, Tottori University Hospital |
| 著者所属 |
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Division of Otolaryngology, Head and Neck Surgery, Department of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
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Department of Pathology, Tottori Prefectural Central Hospital |
| 著者所属 |
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Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
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Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University |
| 著者所属 |
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Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
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|
en |
|
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Department of Pathology, Tottori University Hospital/Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
|
en |
|
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Department of Pathology, Tottori University Hospital |
| 著者所属（英） |
|
|
|
en |
|
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Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University |
| 著者所属（英） |
|
|
|
en |
|
|
Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
|
en |
|
|
Department of Pathology, Tottori University Hospital |
| 著者所属（英） |
|
|
|
en |
|
|
Division of Otolaryngology, Head and Neck Surgery, Department of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
|
en |
|
|
Department of Pathology, Tottori Prefectural Central Hospital |
| 著者所属（英） |
|
|
|
en |
|
|
Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
|
en |
|
|
Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University |
| 著者所属（英） |
|
|
|
en |
|
|
Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine |
| 抄録 |
|
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内容記述タイプ |
Other |
|
内容記述 |
[Background] Adenoid cystic carcinoma (ACC) is a relatively rare malignant neoplasm that occurs in salivary glands and various other organs. Recent studies have revealed that a significant proportion of ACCs harbor gene alterations involving MYB or MYBL1 (mostly fusions with NFIB) in a mutually-exclusive manner. However, its clinical significance remains to be well-established. [Methods] We investigated clinicopathological and molecular features of 36 ACCs with special emphasis on the significance of MYBL1 alterations. Reverse-transcription polymerase-chain reaction (RT-PCR) and fluorescence in-situ hybridization (FISH) were performed to detect MYB/MYBL1-NFIB fusions and MYBL1 alterations, respectively. Immunohistochemistry was performed to evaluate MYB expression in the tumors. The results were correlated with clinicopathological profiles of the patients. [Results] RT-PCR revealed MYB-NFIB and MYBL1-NFIB fusions in 10 (27.8%) and 7 (19.4%) ACCs, respectively, in a mutually-exclusive manner. FISH for MYBL1 rearrangements was successfully performed in 11 cases, and the results were concordant with those of RT-PCR. Immunohistochemically, strong MYB expression was observed in 23 (63.9%) tumors, none of which showed MYBL1 alterations. Clinicopathologically, a trend of a better disease-specific survival was noted in patients with MYBL1 alterations than in those with MYB-NFIB fusions and/or strong MYB expression; however, the difference was not significant. Interestingly, we found tumors with MYBL1 alterations significantly frequently occurred in the mandibular regions (P = 0.012). Moreover, literature review revealed a similar tendency in a previous study. [Conclusion] Our results suggest that there are some biological or etiological differences between ACCs with MYB and MYBL1 alterations. Moreover, the frequent occurrence of MYBL1-associated ACC in the mandibular regions suggests that MYB immunohistochemistry is less useful in diagnosing ACCs arising in these regions. Further studies are warranted to verify our findings. |
| 書誌情報 |
Yonago Acta Medica
en : Yonago Acta Medica
巻 62,
号 1,
p. 67-76,
発行日 2019-03-28
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| 出版者 |
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|
出版者 |
Tottori University Medical Press |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
05135710 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00892882 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.33160/yam.2019.03.010 |
| 権利 |
|
|
権利情報 |
Yonago Acta medica 編集委員会 |
| 情報源 |
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関連名称 |
Yonago Acta Medica. 2019, 62(1), 67-76 |
| 関連サイト |
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識別子タイプ |
URI |
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|
関連識別子 |
https://www.jstage.jst.go.jp/article/yam/62/1/62_2019.03.010/_article/-char/en |
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|
関連名称 |
https://www.jstage.jst.go.jp/article/yam/62/1/62_2019.03.010/_article/-char/en |
| 関連サイト |
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|
識別子タイプ |
URI |
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|
関連識別子 |
http://www.lib.tottori-u.ac.jp/yam/yam/yam62-1/62-1contents.html |
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|
関連名称 |
http://www.lib.tottori-u.ac.jp/yam/yam/yam62-1/62-1contents.html |
| 著者版フラグ |
|
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出版タイプ |
VoR |
| EISSN |
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|
1346-8049 |
yam62(1)_67.pdf (2.1 MB)
