WEKO3
アイテム
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Recent studies have revealed that a significant proportion of ACCs harbor gene alterations involving MYB or MYBL1 (mostly fusions with NFIB) in a mutually-exclusive manner. However, its clinical significance remains to be well-established. [Methods] We investigated clinicopathological and molecular features of 36 ACCs with special emphasis on the significance of MYBL1 alterations. Reverse-transcription polymerase-chain reaction (RT-PCR) and fluorescence in-situ hybridization (FISH) were performed to detect MYB/MYBL1-NFIB fusions and MYBL1 alterations, respectively. Immunohistochemistry was performed to evaluate MYB expression in the tumors. The results were correlated with clinicopathological profiles of the patients. [Results] RT-PCR revealed MYB-NFIB and MYBL1-NFIB fusions in 10 (27.8%) and 7 (19.4%) ACCs, respectively, in a mutually-exclusive manner. FISH for MYBL1 rearrangements was successfully performed in 11 cases, and the results were concordant with those of RT-PCR. Immunohistochemically, strong MYB expression was observed in 23 (63.9%) tumors, none of which showed MYBL1 alterations. Clinicopathologically, a trend of a better disease-specific survival was noted in patients with MYBL1 alterations than in those with MYB-NFIB fusions and/or strong MYB expression; however, the difference was not significant. Interestingly, we found tumors with MYBL1 alterations significantly frequently occurred in the mandibular regions (P = 0.012). Moreover, literature review revealed a similar tendency in a previous study. [Conclusion] Our results suggest that there are some biological or etiological differences between ACCs with MYB and MYBL1 alterations. Moreover, the frequent occurrence of MYBL1-associated ACC in the mandibular regions suggests that MYB immunohistochemistry is less useful in diagnosing ACCs arising in these regions. Further studies are warranted to verify our findings.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Tottori University Medical Press"}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.33160/yam.2019.03.010", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_16": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "Yonago Acta Medica. 2019, 62(1), 67-76"}]}]}, "item_10001_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://www.jstage.jst.go.jp/article/yam/62/1/62_2019.03.010/_article/-char/en"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": 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Possible Relationship Between MYBL1 Alterations and Specific Primary Sites in Adenoid Cystic Carcinoma: A Clinicopathological and Molecular Study of 36 Cases
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||||||||||||||||||
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公開日 | 2019-06-17 | |||||||||||||||||||||||||||||||||||||||||
タイトル | ||||||||||||||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||||||||||||
タイトル | Possible Relationship Between MYBL1 Alterations and Specific Primary Sites in Adenoid Cystic Carcinoma: A Clinicopathological and Molecular Study of 36 Cases | |||||||||||||||||||||||||||||||||||||||||
言語 | ||||||||||||||||||||||||||||||||||||||||||
言語 | eng | |||||||||||||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||||||||||||
主題 | adenoid cystic carcinoma | |||||||||||||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||||||||||||
主題 | fluorescence in-situ hybridization | |||||||||||||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||||||||||||
主題 | mandibular neoplasms | |||||||||||||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||||||||||||
主題 | oncogene fusion | |||||||||||||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||||||||||||
主題 | prognosis | |||||||||||||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||||||||||||
主題 | adenoid cystic carcinoma | |||||||||||||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||||||||||||
主題 | fluorescence in-situ hybridization | |||||||||||||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||||||||||||
主題 | mandibular neoplasms | |||||||||||||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||||||||||||
主題 | oncogene fusion | |||||||||||||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||||||||||||
主題 | prognosis | |||||||||||||||||||||||||||||||||||||||||
資源タイプ | ||||||||||||||||||||||||||||||||||||||||||
資源タイプ | journal article | |||||||||||||||||||||||||||||||||||||||||
著者 |
Endo, Yukari
× Endo, Yukari× Kuwamoto, Satoshi
WEKO
1855
× Ohira, Takahito
WEKO
2784
× Matsushita, Michiko
WEKO
2075
× Matsushige, Takahiro× Fukuhara, Takahiro
WEKO
405
× Nakamoto, Shu× Hayashi, Kazuhiko
WEKO
660
× Kugoh, Hiroyuki
WEKO
1772
× Hirooka, Yasuaki× Endo, Yukari× Matsushige, Takahiro× Nakamoto, Shu× Hirooka, Yasuaki |
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著者所属 | ||||||||||||||||||||||||||||||||||||||||||
Department of Pathology, Tottori University Hospital/Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine | ||||||||||||||||||||||||||||||||||||||||||
著者所属 | ||||||||||||||||||||||||||||||||||||||||||
Department of Pathology, Tottori University Hospital | ||||||||||||||||||||||||||||||||||||||||||
著者所属 | ||||||||||||||||||||||||||||||||||||||||||
Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University | ||||||||||||||||||||||||||||||||||||||||||
著者所属 | ||||||||||||||||||||||||||||||||||||||||||
Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine | ||||||||||||||||||||||||||||||||||||||||||
著者所属 | ||||||||||||||||||||||||||||||||||||||||||
Department of Pathology, Tottori University Hospital | ||||||||||||||||||||||||||||||||||||||||||
著者所属 | ||||||||||||||||||||||||||||||||||||||||||
Division of Otolaryngology, Head and Neck Surgery, Department of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine | ||||||||||||||||||||||||||||||||||||||||||
著者所属 | ||||||||||||||||||||||||||||||||||||||||||
Department of Pathology, Tottori Prefectural Central Hospital | ||||||||||||||||||||||||||||||||||||||||||
著者所属 | ||||||||||||||||||||||||||||||||||||||||||
Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine | ||||||||||||||||||||||||||||||||||||||||||
著者所属 | ||||||||||||||||||||||||||||||||||||||||||
Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University | ||||||||||||||||||||||||||||||||||||||||||
著者所属 | ||||||||||||||||||||||||||||||||||||||||||
Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine | ||||||||||||||||||||||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||||||||||||||||||||||
en | ||||||||||||||||||||||||||||||||||||||||||
Department of Pathology, Tottori University Hospital/Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine | ||||||||||||||||||||||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||||||||||||||||||||||
en | ||||||||||||||||||||||||||||||||||||||||||
Department of Pathology, Tottori University Hospital | ||||||||||||||||||||||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||||||||||||||||||||||
en | ||||||||||||||||||||||||||||||||||||||||||
Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University | ||||||||||||||||||||||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||||||||||||||||||||||
en | ||||||||||||||||||||||||||||||||||||||||||
Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine | ||||||||||||||||||||||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||||||||||||||||||||||
en | ||||||||||||||||||||||||||||||||||||||||||
Department of Pathology, Tottori University Hospital | ||||||||||||||||||||||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||||||||||||||||||||||
en | ||||||||||||||||||||||||||||||||||||||||||
Division of Otolaryngology, Head and Neck Surgery, Department of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine | ||||||||||||||||||||||||||||||||||||||||||
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Department of Pathology, Tottori Prefectural Central Hospital | ||||||||||||||||||||||||||||||||||||||||||
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Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine | ||||||||||||||||||||||||||||||||||||||||||
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Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University | ||||||||||||||||||||||||||||||||||||||||||
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Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine | ||||||||||||||||||||||||||||||||||||||||||
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内容記述タイプ | Other | |||||||||||||||||||||||||||||||||||||||||
内容記述 | [Background] Adenoid cystic carcinoma (ACC) is a relatively rare malignant neoplasm that occurs in salivary glands and various other organs. Recent studies have revealed that a significant proportion of ACCs harbor gene alterations involving MYB or MYBL1 (mostly fusions with NFIB) in a mutually-exclusive manner. However, its clinical significance remains to be well-established. [Methods] We investigated clinicopathological and molecular features of 36 ACCs with special emphasis on the significance of MYBL1 alterations. Reverse-transcription polymerase-chain reaction (RT-PCR) and fluorescence in-situ hybridization (FISH) were performed to detect MYB/MYBL1-NFIB fusions and MYBL1 alterations, respectively. Immunohistochemistry was performed to evaluate MYB expression in the tumors. The results were correlated with clinicopathological profiles of the patients. [Results] RT-PCR revealed MYB-NFIB and MYBL1-NFIB fusions in 10 (27.8%) and 7 (19.4%) ACCs, respectively, in a mutually-exclusive manner. FISH for MYBL1 rearrangements was successfully performed in 11 cases, and the results were concordant with those of RT-PCR. Immunohistochemically, strong MYB expression was observed in 23 (63.9%) tumors, none of which showed MYBL1 alterations. Clinicopathologically, a trend of a better disease-specific survival was noted in patients with MYBL1 alterations than in those with MYB-NFIB fusions and/or strong MYB expression; however, the difference was not significant. Interestingly, we found tumors with MYBL1 alterations significantly frequently occurred in the mandibular regions (P = 0.012). Moreover, literature review revealed a similar tendency in a previous study. [Conclusion] Our results suggest that there are some biological or etiological differences between ACCs with MYB and MYBL1 alterations. Moreover, the frequent occurrence of MYBL1-associated ACC in the mandibular regions suggests that MYB immunohistochemistry is less useful in diagnosing ACCs arising in these regions. Further studies are warranted to verify our findings. | |||||||||||||||||||||||||||||||||||||||||
書誌情報 |
Yonago Acta Medica en : Yonago Acta Medica 巻 62, 号 1, p. 67-76, 発行日 2019-03-28 |
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出版者 | Tottori University Medical Press | |||||||||||||||||||||||||||||||||||||||||
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収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||||||||||||||
収録物識別子 | 05135710 | |||||||||||||||||||||||||||||||||||||||||
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収録物識別子タイプ | NCID | |||||||||||||||||||||||||||||||||||||||||
収録物識別子 | AA00892882 | |||||||||||||||||||||||||||||||||||||||||
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識別子タイプ | DOI | |||||||||||||||||||||||||||||||||||||||||
関連識別子 | 10.33160/yam.2019.03.010 | |||||||||||||||||||||||||||||||||||||||||
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権利情報 | Yonago Acta medica 編集委員会 | |||||||||||||||||||||||||||||||||||||||||
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関連名称 | Yonago Acta Medica. 2019, 62(1), 67-76 | |||||||||||||||||||||||||||||||||||||||||
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識別子タイプ | URI | |||||||||||||||||||||||||||||||||||||||||
関連識別子 | https://www.jstage.jst.go.jp/article/yam/62/1/62_2019.03.010/_article/-char/en | |||||||||||||||||||||||||||||||||||||||||
関連名称 | https://www.jstage.jst.go.jp/article/yam/62/1/62_2019.03.010/_article/-char/en | |||||||||||||||||||||||||||||||||||||||||
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識別子タイプ | URI | |||||||||||||||||||||||||||||||||||||||||
関連識別子 | http://www.lib.tottori-u.ac.jp/yam/yam/yam62-1/62-1contents.html | |||||||||||||||||||||||||||||||||||||||||
関連名称 | http://www.lib.tottori-u.ac.jp/yam/yam/yam62-1/62-1contents.html | |||||||||||||||||||||||||||||||||||||||||
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出版タイプ | VoR | |||||||||||||||||||||||||||||||||||||||||
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1346-8049 |