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High Level Estradiol Induces EBV Reactivation and EBV gp350/220(+)CD138(+) Double-positive B Cell Population in Graves’ Disease Patients and Healthy Controls
https://repository.lib.tottori-u.ac.jp/records/4795
https://repository.lib.tottori-u.ac.jp/records/4795ffb26e9e-9d16-4f00-a1a9-df772692ea0b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
yam62(2)_240.pdf (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-07-23 | |||||
| タイトル | ||||||
| タイトル | High Level Estradiol Induces EBV Reactivation and EBV gp350/220(+)CD138(+) Double-positive B Cell Population in Graves’ Disease Patients and Healthy Controls | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | anti-gp350/220 antibody (72A1) | |||||
| キーワード | ||||||
| 主題 | Epstein-Barr virus, estradiol | |||||
| キーワード | ||||||
| 主題 | Graves’ disease | |||||
| キーワード | ||||||
| 主題 | reactivation | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | anti-gp350/220 antibody (72A1) | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Epstein-Barr virus, estradiol | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Graves’ disease | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | reactivation | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Hara, Sayuri
× Hara, Sayuri× Nagata, Keiko× Nakayama, Yuji× Higaki, Katsumi× Matsushita, Michiko× Kuwamoto, Satoshi× Kato, Masako× Hayashi, Kazuhiko |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Radioisotope Science, Research Initiative Center, Organization for Research Initiative and Promotion | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Graves’ disease occurs predominantly in women. Epstein-Barr virus (EBV) mainly persists in human B lymphocytes, and its reactivation stimulates antibody production. We previously suggested that the EBV reactivation-induced production of TRAb and IgM at 100 nM estradiol (pregnant level) was lower than that at 0 nM estradiol and that class switch recombination may be increased by estradiol. In this study, we examined the effect of estradiol on EBV reactivation. We identified the expression of EBV-glycoprotein 350/220 (gp350/220) in the late phase of reactivation and plasma cell differentiation of EBV-infected cells using 72A1 antibody and CD138 antibody, respectively. We found the mean ratio of gp 350/220(+) CD138(+) cells at 100 nM estradiol was higher than that at 0 nM estradiol. These results suggested that EBV-infected cells could survive with keeping the ability of antibody production in 100 nM estradiol, which is consistent with the improvement of Graves’ disease during maternity and exacerbation postpartum. | |||||
| 書誌情報 |
Yonago Acta Medica en : Yonago Acta Medica 巻 62, 号 2, p. 240-243, 発行日 2019-06-20 |
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| 出版者 | ||||||
| 出版者 | Tottori University Medical Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05135710 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.33160/yam.2019.06.010 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Sayuri Hara, Keiko Nagata, Yuji Nakayama, Katsumi Higaki, Michiko Matsushita, Satoshi Kuwamoto, Masako Kato, Kazuhiko Hayashi, High Level Estradiol Induces EBV Reactivation and EBV gp350/220(+)CD138(+) Double-positive B Cell Population in Graves’ Disease | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.lib.tottori-u.ac.jp/yam/yam/yam62-2/62-2contents.html | |||||
| 関連名称 | http://www.lib.tottori-u.ac.jp/yam/yam/yam62-2/62-2contents.html | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/yam/62/2/62_2019.06.010/_article/ | |||||
| 関連名称 | https://www.jstage.jst.go.jp/article/yam/62/2/62_2019.06.010/_article/ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| EISSN | ||||||
| 値 | 1346-8049 | |||||
