| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-07-23 |
| タイトル |
|
|
タイトル |
High Level Estradiol Induces EBV Reactivation and EBV gp350/220(+)CD138(+) Double-positive B Cell Population in Graves’ Disease Patients and Healthy Controls |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
anti-gp350/220 antibody (72A1) |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Epstein-Barr virus, estradiol |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Graves’ disease |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
reactivation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
anti-gp350/220 antibody (72A1) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Epstein-Barr virus, estradiol |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Graves’ disease |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
reactivation |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
Hara, Sayuri
Nagata, Keiko
Nakayama, Yuji
Higaki, Katsumi
Matsushita, Michiko
Kuwamoto, Satoshi
Kato, Masako
Hayashi, Kazuhiko
|
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Radioisotope Science, Research Initiative Center, Organization for Research Initiative and Promotion |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Graves’ disease occurs predominantly in women. Epstein-Barr virus (EBV) mainly persists in human B lymphocytes, and its reactivation stimulates antibody production. We previously suggested that the EBV reactivation-induced production of TRAb and IgM at 100 nM estradiol (pregnant level) was lower than that at 0 nM estradiol and that class switch recombination may be increased by estradiol. In this study, we examined the effect of estradiol on EBV reactivation. We identified the expression of EBV-glycoprotein 350/220 (gp350/220) in the late phase of reactivation and plasma cell differentiation of EBV-infected cells using 72A1 antibody and CD138 antibody, respectively. We found the mean ratio of gp 350/220(+) CD138(+) cells at 100 nM estradiol was higher than that at 0 nM estradiol. These results suggested that EBV-infected cells could survive with keeping the ability of antibody production in 100 nM estradiol, which is consistent with the improvement of Graves’ disease during maternity and exacerbation postpartum. |
| 書誌情報 |
Yonago Acta Medica
en : Yonago Acta Medica
巻 62,
号 2,
p. 240-243,
発行日 2019-06-20
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| 出版者 |
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|
出版者 |
Tottori University Medical Press |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
05135710 |
| 書誌レコードID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00892882 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.33160/yam.2019.06.010 |
| 権利 |
|
|
権利情報 |
Yonago Acta medica 編集委員会 |
| 情報源 |
|
|
|
関連名称 |
Sayuri Hara, Keiko Nagata, Yuji Nakayama, Katsumi Higaki, Michiko Matsushita, Satoshi Kuwamoto, Masako Kato, Kazuhiko Hayashi, High Level Estradiol Induces EBV Reactivation and EBV gp350/220(+)CD138(+) Double-positive B Cell Population in Graves’ Disease |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
http://www.lib.tottori-u.ac.jp/yam/yam/yam62-2/62-2contents.html |
|
|
関連名称 |
http://www.lib.tottori-u.ac.jp/yam/yam/yam62-2/62-2contents.html |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.jstage.jst.go.jp/article/yam/62/2/62_2019.06.010/_article/ |
|
|
関連名称 |
https://www.jstage.jst.go.jp/article/yam/62/2/62_2019.06.010/_article/ |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
| EISSN |
|
|
値 |
1346-8049 |
yam62(2)_240.pdf (1.3 MB)
