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Indirubin, a Constituent of the Chinese Herbal Medicine Qing-Dai, Attenuates Dextran Sulfate Sodium-induced Murine Colitis
https://repository.lib.tottori-u.ac.jp/records/4823
https://repository.lib.tottori-u.ac.jp/records/48237bf06071-67aa-41f0-9440-7bf2d64ea26f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
yam61(2)_128.pdf (2.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2018-06-22 | |||||||||
| タイトル | ||||||||||
| タイトル | Indirubin, a Constituent of the Chinese Herbal Medicine Qing-Dai, Attenuates Dextran Sulfate Sodium-induced Murine Colitis | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | Chinese herbal medicine | |||||||||
| キーワード | ||||||||||
| 主題 | DSS-induced colitis model | |||||||||
| キーワード | ||||||||||
| 主題 | indirubin | |||||||||
| キーワード | ||||||||||
| 主題 | inflammatory bowel disease | |||||||||
| キーワード | ||||||||||
| 主題 | Qing-Dai | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題 | Chinese herbal medicine | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題 | DSS-induced colitis model | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題 | indirubin | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題 | inflammatory bowel disease | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題 | Qing-Dai | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
Tokuyasu, Naruo
× Tokuyasu, Naruo× Shomori, Kohei× Amano, Kuniki× Honjo, Soichiro× Sakamoto, Teruhisa× Watanabe, Joji× Amisaki, Masataka× Morimoto, Masaki× Uchinaka, Ei× Yagyu, Takuki× Saito, Hiroaki× Ito, Hisao× Fujiwara, Yoshiyuki
WEKO
377
× Amano, Kuniki× Uchinaka, Ei× Yagyu, Takuki |
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| 著者所属 | ||||||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine/Division of Organ Pathology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of Organ Pathology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Sky Clinic | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of Organ Pathology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 【Background】Indirubin, a constituent of the Chinese herbal medicine “Qing-Dai,” has anti-cancer and anti-inflammatory activities. We aimed to evaluate the efficacy of indirubin for ameliorating colonic inflammation in a mouse model of inflammatory bowel disease. 【Methods】Mice with dextran sulfate sodium (DSS)induced acute and chronic colitis were treated with indirubin in their diet. Clinical and histologic changes were evaluated. In addition, colon levels of interleukin-6, a critical pro-inflammatory mediator, was detected by enzyme-linked immunosorbent assay. 【Results】In the model of acute colitis, indirubin treatment improved the loss of body weight. Histology of colonic tissue revealed that indirubin treatment improved the histology grading of colitis (P = 0.02), the extent of submucosal fibrosis (P = 0.018), the number of mucosal toluidine blue-positive cells (P = 0.004) and colon length (P = 0.01). In the model of chronic colitis, indirubin treatment had no significant effect on pathologic findings except for colon length (P = 0.003). However, indirubin administration significantly reduced colon levels of interleukin-6 in the chronic-colitis model (P = 0.001). 【Conclusion】Our study clearly showed that oral intake of indirubin can improve murine DSS-induced colitis (which mimics human inflammatory bowel disease). | |||||||||
| 書誌情報 |
Yonago Acta Medica en : Yonago Acta Medica 巻 61, 号 2, p. 128-136, 発行日 2018-06-18 |
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| 出版者 | ||||||||||
| 出版者 | Tottori University Faculty of Medicine | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 05135710 | |||||||||
| 書誌レコードID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA00892882 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.33160/yam.2018.06.005 | |||||||||
| 権利 | ||||||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||||||
| 情報源 | ||||||||||
| 関連名称 | Yonago Acta Medica. 2018,61(2), 128-136 | |||||||||
| 関連サイト | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | http://www.lib.tottori-u.ac.jp/yam/yam/yam61-2/61-2contents.html | |||||||||
| 関連名称 | http://www.lib.tottori-u.ac.jp/yam/yam/yam61-2/61-2contents.html | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| EISSN | ||||||||||
| 値 | 1346-8049 | |||||||||
