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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
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  2. 学術雑誌論文
  1. 鳥取大学の刊行物
  2. Yonago Acta Medica
  3. 60
  4. 3

Higher Expression of Activation-induced Cytidine Deaminase Is Significantly Associated with Merkel Cell Polyomavirus-negative Merkel Cell Carcinomas

https://repository.lib.tottori-u.ac.jp/records/4863
https://repository.lib.tottori-u.ac.jp/records/4863
56230922-03db-42d4-bc64-3ee7aea81942
名前 / ファイル ライセンス アクション
yam60(3)_145.pdf yam60(3)_145.pdf (3.5 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-06-22
タイトル
タイトル Higher Expression of Activation-induced Cytidine Deaminase Is Significantly Associated with Merkel Cell Polyomavirus-negative Merkel Cell Carcinomas
言語 en
言語
言語 eng
キーワード
主題 activation-induced cytidine deaminase
キーワード
主題 Merkel cell carcinoma
キーワード
主題 Merkel cell polyomavirus
キーワード
言語 en
主題 activation-induced cytidine deaminase
キーワード
言語 en
主題 Merkel cell carcinoma
キーワード
言語 en
主題 Merkel cell polyomavirus
資源タイプ
資源タイプ journal article
著者 Matsushita, Michiko

× Matsushita, Michiko

WEKO 2075
e-Rad 70642198
研究者総覧鳥取大学 100000920

Matsushita, Michiko

en Matsushita, Michiko

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Iwasaki, Takeshi

× Iwasaki, Takeshi

WEKO 17562

Iwasaki, Takeshi

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Nonaka, Daisuke

× Nonaka, Daisuke

WEKO 17563

Nonaka, Daisuke

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Kuwamoto, Satoshi

× Kuwamoto, Satoshi

WEKO 1855
e-Rad 60567189
研究者総覧鳥取大学 100000360

Kuwamoto, Satoshi

en Kuwamoto, Satoshi

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Nagata, Keiko

× Nagata, Keiko

WEKO 2430
e-Rad 50304209
研究者総覧鳥取大学 100001779

Nagata, Keiko

en Nagata, Keiko

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Kato, Masako

× Kato, Masako

WEKO 1365
e-Rad 80221183
研究者総覧鳥取大学 100000126

Kato, Masako

en Kato, Masako

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Kitamura, Yukisato

× Kitamura, Yukisato

WEKO 1585
e-Rad 20204919
研究者総覧鳥取大学 100000144

Kitamura, Yukisato

en Kitamura, Yukisato

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Hayashi, Kazuhiko

× Hayashi, Kazuhiko

WEKO 660
e-Rad 30180962
研究者総覧鳥取大学 100000220

Hayashi, Kazuhiko

en Hayashi, Kazuhiko

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Iwasaki, Takeshi

× Iwasaki, Takeshi

WEKO 17564

en Iwasaki, Takeshi

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Nonaka, Daisuke

× Nonaka, Daisuke

WEKO 17565

en Nonaka, Daisuke

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著者所属
値 Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine
著者所属
値 Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University
著者所属
値 Department of Histopathology, The Christie NHS Foundation Trust
著者所属
値 Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine
著者所属
値 Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine
著者所属
値 Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine
著者所属
値 Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine
著者所属
値 Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine
抄録
内容記述タイプ Other
内容記述 [Background] Merkel cell carcinomas (MCCs), clinically aggressive neuroendocrine skin cancers, are divided into Merkel cell polyomavirus (MCPyV)-positive and-negative tumors, which show different clinicopathological features and may develop through different mechanisms of carcinogenesis. Aberrant expression of activation-induced cytidine deaminase (AID) as a genomic modulator was demonstrated through pathogen-related NF-κB signal in Helicobacter pylori-associated gastric cancer, adult T cell leukemia/lymphoma (HTLV-1), hepatoma(HCV), and Burkitt lymphoma (EBV). [Methods] To elucidate the relation of aberrant AID expression in MCPyV-positive and -negative MCCs, we evaluated immunohistochemical expressions of AID and AID-regulating factors between 24 MCPyV-positive and 17 MCPyV-negative MCCs. [Results] AID expression was significantly higher in MCPyV-negative MCCs than MCPyV-positive ones (P = 0.026), although expression of NF-κB p65 (phospho S536) (AID-enhancer) was significantly higher in MCPyV-positive MCCs than MCPyV-negative ones (P = 0.034). Expressions of PAX5 and c-Myb were not significantly different between these subgroups. Expressions of AID and AID-regulating factors were not correlated to prognosis of MCC patients. [Conclusion] Our findings suggest that although pathogen-induced AID expression through upregulationof NF-κB may be relevant to carcinogenesis of MCPyV-positive MCCs, the significantly higher aberrant AID expression in MCPyV-negative MCCs is consistent with the fact that MCPyV-negative MCCs have an extremely extremely higher mutation burden than MCPyV-positive ones.
書誌情報 Yonago Acta Medica
en : Yonago Acta Medica

巻 60, 号 3, p. 145-153, 発行日 2017-09-15
出版者
出版者 Tottori University Faculty of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05135710
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00892882
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.33160/yam.2017.09.002
権利
権利情報 Yonago Acta medica 編集委員会
情報源
関連名称 Yonago Acta Medica. 2017, 60(3), 145-153
関連サイト
識別子タイプ URI
関連識別子 http://www.lib.tottori-u.ac.jp/yam/yam/yam60-3/yam-60-145.pdf
関連名称 http://www.lib.tottori-u.ac.jp/yam/yam/yam60-3/yam-60-145.pdf
著者版フラグ
出版タイプ VoR
EISSN
値 1346-8049
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