{"_buckets": {"deposit": "5ab1f4ef-05da-4470-9425-b92d87e31c3e"}, "_deposit": {"created_by": 10, "id": "4863", "owners": [10], "pid": {"revision_id": 0, "type": "depid", "value": "4863"}, "status": "published"}, "_oai": {"id": "oai:repository.lib.tottori-u.ac.jp:00004863", "sets": ["12", "9", "1006"]}, "author_link": ["2075", "17562", "17563", "1855", "2430", "1365", "1585", "660", "17564", "17565"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-09-15", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "153", "bibliographicPageStart": "145", "bibliographicVolumeNumber": "60", "bibliographic_titles": [{"bibliographic_title": "Yonago Acta Medica"}, {"bibliographic_title": "Yonago Acta Medica", "bibliographic_titleLang": "en"}]}]}, "item_10001_checkbox_27": {"attribute_name": "部局名", "attribute_value_mlt": [{"subitem_checkbox_item": ["i-gakubu"]}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "[Background] Merkel cell carcinomas (MCCs), clinically aggressive neuroendocrine skin cancers, are divided into Merkel cell polyomavirus (MCPyV)-positive and-negative tumors, which show different clinicopathological features and may develop through different mechanisms of carcinogenesis. Aberrant expression of activation-induced cytidine deaminase (AID) as a genomic modulator was demonstrated through pathogen-related NF-κB signal in Helicobacter pylori-associated gastric cancer, adult T cell leukemia/lymphoma (HTLV-1), hepatoma(HCV), and Burkitt lymphoma (EBV). [Methods] To elucidate the relation of aberrant AID expression in MCPyV-positive and -negative MCCs, we evaluated immunohistochemical expressions of AID and AID-regulating factors between 24 MCPyV-positive and 17 MCPyV-negative MCCs. [Results] AID expression was significantly higher in MCPyV-negative MCCs than MCPyV-positive ones (P = 0.026), although expression of NF-κB p65 (phospho S536) (AID-enhancer) was significantly higher in MCPyV-positive MCCs than MCPyV-negative ones (P = 0.034). Expressions of PAX5 and c-Myb were not significantly different between these subgroups. Expressions of AID and AID-regulating factors were not correlated to prognosis of MCC patients. [Conclusion] Our findings suggest that although pathogen-induced AID expression through upregulationof NF-κB may be relevant to carcinogenesis of MCPyV-positive MCCs, the significantly higher aberrant AID expression in MCPyV-negative MCCs is consistent with the fact that MCPyV-negative MCCs have an extremely extremely higher mutation burden than MCPyV-positive ones.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Tottori University Faculty of Medicine"}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.33160/yam.2017.09.002", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_16": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "Yonago Acta Medica. 2017, 60(3), 145-153"}]}]}, 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"attribute_value_mlt": [{"subitem_text_value": "1346-8049"}]}, "item_10001_text_29": {"attribute_name": "最新掲載誌名", "attribute_value_mlt": [{"subitem_text_value": "yam;Yonago Acta medica;Yonago Acta medica"}]}, "item_10001_text_32": {"attribute_name": "著者所属", "attribute_value_mlt": [{"subitem_text_value": "Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine"}, {"subitem_text_value": "Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University"}, {"subitem_text_value": "Department of Histopathology, The Christie NHS Foundation Trust"}, {"subitem_text_value": "Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine"}, {"subitem_text_value": "Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine"}, {"subitem_text_value": "Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine"}, {"subitem_text_value": "Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine"}, {"subitem_text_value": "Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Matsushita, Michiko"}, {"creatorName": "Matsushita, Michiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "2075", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70642198", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70642198"}, {"nameIdentifier": "100000920", "nameIdentifierScheme": "研究者総覧鳥取大学", 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{"creatorNames": [{"creatorName": "Nonaka, Daisuke", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "17565", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "yam60(3)_145.pdf", "filesize": [{"value": "3.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Yonago Acta medica　編集委員会", "licensetype": "license_note", "mimetype": "application/pdf", "size": 3500000.0, "url": {"label": "yam60(3)_145.pdf", "url": "https://repository.lib.tottori-u.ac.jp/record/4863/files/yam60(3)_145.pdf"}, "version_id": "b968bd60-f472-4934-a324-c0daa1cb18dd"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "activation-induced cytidine 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