Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2018-06-22 |
タイトル |
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言語 |
en |
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タイトル |
Higher Expression of Activation-induced Cytidine Deaminase Is Significantly Associated with Merkel Cell Polyomavirus-negative Merkel Cell Carcinomas |
言語 |
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言語 |
eng |
キーワード |
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主題Scheme |
Other |
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主題 |
activation-induced cytidine deaminase |
キーワード |
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主題Scheme |
Other |
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主題 |
Merkel cell carcinoma |
キーワード |
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主題Scheme |
Other |
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主題 |
Merkel cell polyomavirus |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
activation-induced cytidine deaminase |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Merkel cell carcinoma |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Merkel cell polyomavirus |
資源タイプ |
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資源タイプ |
journal article |
著者 |
Matsushita, Michiko
Iwasaki, Takeshi
Nonaka, Daisuke
Kuwamoto, Satoshi
Nagata, Keiko
Kato, Masako
Kitamura, Yukisato
Hayashi, Kazuhiko
Iwasaki, Takeshi
Nonaka, Daisuke
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著者所属 |
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Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine |
著者所属 |
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Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University |
著者所属 |
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Department of Histopathology, The Christie NHS Foundation Trust |
著者所属 |
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Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine |
著者所属 |
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Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine |
著者所属 |
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Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine |
著者所属 |
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Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine |
著者所属 |
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Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine |
抄録 |
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内容記述タイプ |
Other |
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内容記述 |
[Background] Merkel cell carcinomas (MCCs), clinically aggressive neuroendocrine skin cancers, are divided into Merkel cell polyomavirus (MCPyV)-positive and-negative tumors, which show different clinicopathological features and may develop through different mechanisms of carcinogenesis. Aberrant expression of activation-induced cytidine deaminase (AID) as a genomic modulator was demonstrated through pathogen-related NF-κB signal in Helicobacter pylori-associated gastric cancer, adult T cell leukemia/lymphoma (HTLV-1), hepatoma(HCV), and Burkitt lymphoma (EBV). [Methods] To elucidate the relation of aberrant AID expression in MCPyV-positive and -negative MCCs, we evaluated immunohistochemical expressions of AID and AID-regulating factors between 24 MCPyV-positive and 17 MCPyV-negative MCCs. [Results] AID expression was significantly higher in MCPyV-negative MCCs than MCPyV-positive ones (P = 0.026), although expression of NF-κB p65 (phospho S536) (AID-enhancer) was significantly higher in MCPyV-positive MCCs than MCPyV-negative ones (P = 0.034). Expressions of PAX5 and c-Myb were not significantly different between these subgroups. Expressions of AID and AID-regulating factors were not correlated to prognosis of MCC patients. [Conclusion] Our findings suggest that although pathogen-induced AID expression through upregulationof NF-κB may be relevant to carcinogenesis of MCPyV-positive MCCs, the significantly higher aberrant AID expression in MCPyV-negative MCCs is consistent with the fact that MCPyV-negative MCCs have an extremely extremely higher mutation burden than MCPyV-positive ones. |
書誌情報 |
Yonago Acta Medica
en : Yonago Acta Medica
巻 60,
号 3,
p. 145-153,
発行日 2017-09-15
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出版者 |
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出版者 |
Tottori University Faculty of Medicine |
ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
05135710 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00892882 |
DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.33160/yam.2017.09.002 |
権利 |
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権利情報 |
Yonago Acta medica 編集委員会 |
情報源 |
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関連名称 |
Yonago Acta Medica. 2017, 60(3), 145-153 |
関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
http://www.lib.tottori-u.ac.jp/yam/yam/yam60-3/yam-60-145.pdf |
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関連名称 |
http://www.lib.tottori-u.ac.jp/yam/yam/yam60-3/yam-60-145.pdf |
著者版フラグ |
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出版タイプ |
VoR |
EISSN |
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1346-8049 |