| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-06-22 |
| タイトル |
|
|
タイトル |
Protective Effects of Ginger against Aspirin-Induced Gastric Ulcers in Rats |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
aspirin |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
gastric damage |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
ginger powder |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
inflammatory cytokine |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
inducible form of NO synthase activity |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
aspirin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
gastric damage |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ginger powder |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
inflammatory cytokine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
inducible form of NO synthase activity |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
Wang, Zhongzhi
Hasegawa, Junichi
Wang, Xinhui
Matsuda, Akiko
Tokuda, Takahiro
Miura, Norimasa
Watanabe, Tatsuo
Wang, Zhongzhi
Wang, Xinhui
Tokuda, Takahiro
|
| 著者所属 |
|
|
値 |
Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, School of Medicine, Tottori University Faculty of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
We investigated the mechanism underlying the protective effects of ginger against gastric damage induced by aspirin in rats. Gastric mucosal lesions were produced by orally administering 200 mg/kg aspirin suspended in 1% carboxymethylcellulose solution to pyloric-ligated male Wistar rats. Ginger powder (200 mg/kg) markedly reduced the aspirin-induced gastric hemorrhagic ulcer area. The total acidity of gastric juice was not significantly influenced by aspirin or ginger. Ginger powder did not affect the aspirin-induced reduction in mucosal prostaglandin E2 (PGE2) content; however, it did ameliorate the aspirin-induced increases in mucosal activity of the inducible form of NO synthase (iNOS) and plasma tumor necrosis factor (TNF)-α and interleukin (IL)-1β levels. In the next experiment, high and low doses of 6-gingerol and 6-shogaol were used instead of ginger powder in the same experimental model to examine their roles in the anti-ulcer mechanism of ginger. Both 6-gingerol and 6-shogaol reduced aspirin induced ulcer formation, mucosal iNOS and plasma TNF-α and IL-1β levels. In conclusion, ginger powder prevents the aspirin induced gastric ulcer formation by reducing mucosal iNOS activity and the plasma levels of inflammatory cytokines but does not affect gastric juice or acid production or mucosal PGE2 content. This protective effect of ginger powder against gastric ulcers may be attributable to both gingerol and shogaol. |
| 書誌情報 |
Yonago Acta medica
en : Yonago Acta medica
巻 54,
号 1,
p. 11-19,
発行日 2011-03
|
| 出版者 |
|
|
出版者 |
Tottori University Faculty of Medicine |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13468049 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00892882 |
| 権利 |
|
|
権利情報 |
Yonago Acta medica 編集委員会 |
| 情報源 |
|
|
|
関連名称 |
Yonago Acta medica. 2011, 54(1), 11-19 |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
http://www.lib.tottori-u.ac.jp/yam/yam/yam54-1/yam54_011-019.html |
|
|
関連名称 |
http://www.lib.tottori-u.ac.jp/yam/yam/yam54-1/yam54_011-019.html |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
54_011-019.pdf (580.7 kB)
