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NKG2D+CD4+ T Cells with Immune Suppressive Property Increase in Patients with Colorectal Cancer
https://repository.lib.tottori-u.ac.jp/records/5008
https://repository.lib.tottori-u.ac.jp/records/50083ad072ee-c431-4b63-97fa-7eafb12bc5ff
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
53_009-016.pdf (303.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | NKG2D+CD4+ T Cells with Immune Suppressive Property Increase in Patients with Colorectal Cancer | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | CD4+ T lymphocyte | |||||
| キーワード | ||||||
| 主題 | colorectal cancer | |||||
| キーワード | ||||||
| 主題 | NKG2D | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | CD4+ T lymphocyte | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | colorectal cancer | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | NKG2D | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Yamamoto, Manabu
× Yamamoto, Manabu× Saito, Hiroaki× Kihara, Kyoichi× Katano, Kuniyuki× Ikeguchi, Masahide× Kihara, Kyoichi× Katano, Kuniyuki |
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| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Some studies suggest that small populations of CD4+ T cells with activation-independent, constitutive, NKG2D expression are found in normal peripheral blood and have immune suppressive properties. The present study was designed to investigate NKG2D expression on CD4+ T lymphocytes and its relationship to immune evasion in colorectal cancer patients. We examined NKG2D expression on both circulating and tumor infiltrating CD4+ and CD8+ T cells or NK cells and evaluated it by multicolor flow cytometry. Furthermore, intracellular cytokine staining was carried out to determine the cytokine profile of NKG2D+CD4+ T cells in colorectal cancer patients. As a result, NKG2D expression on circulating and tumor-infiltrating CD8+ T cells and NK cells was downregulated in colorectal cancer patients. On the other hand, circulating and tumor-infiltrating NKG2D+CD4+ T cells increased in colorectal cancer patients. NKG2D+CD4+ T cells produced more immune suppressive cytokines, such as interleukin-10 and transforming growth factor-1β, than did NKG2D-CD4+ T cells. Increased NKG2D+CD4+ T cells as well as decreased NKG2D expression on CD8+ T cells and NK cells may be one of the key mechanisms responsible for immune evasion by tumors in colorectal cancer. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 53, 号 1, p. 9-16, 発行日 2010-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2010, 53(1), 9-16 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
