| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-06-22 |
| タイトル |
|
|
タイトル |
NKG2D+CD4+ T Cells with Immune Suppressive Property Increase in Patients with Colorectal Cancer |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
CD4+ T lymphocyte |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
colorectal cancer |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
NKG2D |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
CD4+ T lymphocyte |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
colorectal cancer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
NKG2D |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
Yamamoto, Manabu
Saito, Hiroaki
Kihara, Kyoichi
Katano, Kuniyuki
Ikeguchi, Masahide
Kihara, Kyoichi
Katano, Kuniyuki
|
| 著者所属 |
|
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Some studies suggest that small populations of CD4+ T cells with activation-independent, constitutive, NKG2D expression are found in normal peripheral blood and have immune suppressive properties. The present study was designed to investigate NKG2D expression on CD4+ T lymphocytes and its relationship to immune evasion in colorectal cancer patients. We examined NKG2D expression on both circulating and tumor infiltrating CD4+ and CD8+ T cells or NK cells and evaluated it by multicolor flow cytometry. Furthermore, intracellular cytokine staining was carried out to determine the cytokine profile of NKG2D+CD4+ T cells in colorectal cancer patients. As a result, NKG2D expression on circulating and tumor-infiltrating CD8+ T cells and NK cells was downregulated in colorectal cancer patients. On the other hand, circulating and tumor-infiltrating NKG2D+CD4+ T cells increased in colorectal cancer patients. NKG2D+CD4+ T cells produced more immune suppressive cytokines, such as interleukin-10 and transforming growth factor-1β, than did NKG2D-CD4+ T cells. Increased NKG2D+CD4+ T cells as well as decreased NKG2D expression on CD8+ T cells and NK cells may be one of the key mechanisms responsible for immune evasion by tumors in colorectal cancer. |
| 書誌情報 |
Yonago Acta medica
en : Yonago Acta medica
巻 53,
号 1,
p. 9-16,
発行日 2010-03
|
| 出版者 |
|
|
出版者 |
Tottori University Faculty of Medicine |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13468049 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00892882 |
| 権利 |
|
|
権利情報 |
Yonago Acta medica 編集委員会 |
| 情報源 |
|
|
|
関連名称 |
Yonago Acta medica. 2010, 53(1), 9-16 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
53_009-016.pdf (303.5 kB)
