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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
  1. 資料タイプ一覧
  2. 学術雑誌論文
  1. 鳥取大学の刊行物
  2. Yonago Acta Medica
  3. 53
  4. 2

Niemann-Pick C1-Like 1: A Key Player in Intestinal Cholesterol Absorption

https://repository.lib.tottori-u.ac.jp/records/5011
https://repository.lib.tottori-u.ac.jp/records/5011
9f6b2c54-8cf8-4b1d-8c28-c15650b33d2f
名前 / ファイル ライセンス アクション
53_029-036.pdf 53_029-036.pdf (315.5 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-06-22
タイトル
言語 en
タイトル Niemann-Pick C1-Like 1: A Key Player in Intestinal Cholesterol Absorption
言語
言語 eng
キーワード
主題 ABCG5/G8
キーワード
主題 cholesterol
キーワード
主題 low-density lipoprotein
キーワード
主題 Niemann-Pick
キーワード
主題 Niemann-Pick disease type C1-like 1
キーワード
言語 en
主題 ABCG5/G8
キーワード
言語 en
主題 cholesterol
キーワード
言語 en
主題 low-density lipoprotein
キーワード
言語 en
主題 Niemann-Pick
キーワード
言語 en
主題 Niemann-Pick disease type C1-like 1
資源タイプ
資源タイプ journal article
著者 Ninomiya, Haruaki

× Ninomiya, Haruaki

WEKO 2609
e-Rad 80212124
研究者総覧鳥取大学 100000212

Ninomiya, Haruaki

en Ninomiya, Haruaki

Search repository
著者所属
Department of Biological Regulations, School of Health Science, Tottori University Faculty of Medicine
抄録
内容記述タイプ Other
内容記述 Niemann-Pick C1-Like 1 (NPC1-L1), as its name indicates, was identified in 2000 as a homolog of NPC1. Its major physiological function was clarified by a research group in Shöring’s laboratory who had long been searching for a target of ezetimibe, a cholesterol-lowering drug. They published a paper on 2004 in Science, reporting a reduction of intestinal cholesterol absorption and a lack of effects of ezetimibe in NPC1-L1 knockout mice. With subsequent studies that confirmed their findings, it is now clear that NPC1-L1 is a key player in one of the major pathways of intestinal cholesterol absorption and that it is the target of ezetimibe. This review summarizes what has been shown up to now about the structure and function of NPC1-L1. This review also refers to ABCG5/G8, a member of ABC family transporters, which co-localizes with NPC1-L1 on the intestinal epithelial cells and appears to work in a closely related manner.
書誌情報 Yonago Acta medica
en : Yonago Acta medica

巻 53, 号 2, p. 29-36, 発行日 2010-06
出版者
出版者 Tottori University Faculty of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 13468049
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00892882
権利
権利情報 Yonago Acta medica 編集委員会
情報源
関連名称 Yonago Acta medica. 2010, 53(2), 29-36
関連サイト
識別子タイプ URI
関連識別子 https://www.lib.tottori-u.ac.jp/yam/yam/yam53-2/yam53_029-036.html
関連名称 https://www.lib.tottori-u.ac.jp/yam/yam/yam53-2/yam53_029-036.html
著者版フラグ
出版タイプ VoR
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