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Niemann-Pick C1-Like 1: A Key Player in Intestinal Cholesterol Absorption
https://repository.lib.tottori-u.ac.jp/records/5011
https://repository.lib.tottori-u.ac.jp/records/50119f6b2c54-8cf8-4b1d-8c28-c15650b33d2f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
53_029-036.pdf (315.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Niemann-Pick C1-Like 1: A Key Player in Intestinal Cholesterol Absorption | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | ABCG5/G8 | |||||
| キーワード | ||||||
| 主題 | cholesterol | |||||
| キーワード | ||||||
| 主題 | low-density lipoprotein | |||||
| キーワード | ||||||
| 主題 | Niemann-Pick | |||||
| キーワード | ||||||
| 主題 | Niemann-Pick disease type C1-like 1 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | ABCG5/G8 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | cholesterol | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | low-density lipoprotein | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Niemann-Pick | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Niemann-Pick disease type C1-like 1 | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Ninomiya, Haruaki
× Ninomiya, Haruaki |
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| 著者所属 | ||||||
| 値 | Department of Biological Regulations, School of Health Science, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Niemann-Pick C1-Like 1 (NPC1-L1), as its name indicates, was identified in 2000 as a homolog of NPC1. Its major physiological function was clarified by a research group in Shöring’s laboratory who had long been searching for a target of ezetimibe, a cholesterol-lowering drug. They published a paper on 2004 in Science, reporting a reduction of intestinal cholesterol absorption and a lack of effects of ezetimibe in NPC1-L1 knockout mice. With subsequent studies that confirmed their findings, it is now clear that NPC1-L1 is a key player in one of the major pathways of intestinal cholesterol absorption and that it is the target of ezetimibe. This review summarizes what has been shown up to now about the structure and function of NPC1-L1. This review also refers to ABCG5/G8, a member of ABC family transporters, which co-localizes with NPC1-L1 on the intestinal epithelial cells and appears to work in a closely related manner. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 53, 号 2, p. 29-36, 発行日 2010-06 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2010, 53(2), 29-36 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.lib.tottori-u.ac.jp/yam/yam/yam53-2/yam53_029-036.html | |||||
| 関連名称 | https://www.lib.tottori-u.ac.jp/yam/yam/yam53-2/yam53_029-036.html | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
