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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
  1. 資料タイプ一覧
  2. 学術雑誌論文
  1. 鳥取大学の刊行物
  2. Yonago Acta Medica
  3. 52
  4. 1

Variations in Clinical Findings of Patients with Identical Tuberous Sclerosis Gene Mutations

https://repository.lib.tottori-u.ac.jp/records/5025
https://repository.lib.tottori-u.ac.jp/records/5025
ecd184c5-07fd-4d37-aeb6-a35632793590
名前 / ファイル ライセンス アクション
52_057-072.pdf 52_057-072.pdf (384.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-06-22
タイトル
タイトル Variations in Clinical Findings of Patients with Identical Tuberous Sclerosis Gene Mutations
言語 en
言語
言語 eng
キーワード
主題 colorectal neoplasm
キーワード
主題 gene analysis
キーワード
主題 matrix metalloproteinase
キーワード
主題 polymorphism
キーワード
主題 tumor necrosis factor-alpha
キーワード
言語 en
主題 colorectal neoplasm
キーワード
言語 en
主題 gene analysis
キーワード
言語 en
主題 matrix metalloproteinase
キーワード
言語 en
主題 polymorphism
キーワード
言語 en
主題 tumor necrosis factor-alpha
資源タイプ
資源タイプ journal article
著者 Sakurai, Yuko

× Sakurai, Yuko

WEKO 18440

Sakurai, Yuko

Search repository
Saito, Yoshiaki

× Saito, Yoshiaki

WEKO 3096
e-Rad 30328421
研究者総覧鳥取大学 100001228

Saito, Yoshiaki

en Saito, Yoshiaki

Search repository
Nanba, Eiji

× Nanba, Eiji

WEKO 2573
e-Rad 40237631
研究者総覧鳥取大学 100000739

Nanba, Eiji

en Nanba, Eiji

Search repository
Yamamoto, Toshiyuki

× Yamamoto, Toshiyuki

WEKO 18441

Yamamoto, Toshiyuki

Search repository
Ohno, Kousaku

× Ohno, Kousaku

WEKO 2804
e-Rad 70112109

Ohno, Kousaku

en Ohno, Kousaku

Search repository
Sakurai, Yuko

× Sakurai, Yuko

WEKO 18442

en Sakurai, Yuko

Search repository
Yamamoto, Toshiyuki

× Yamamoto, Toshiyuki

WEKO 18443

en Yamamoto, Toshiyuki

Search repository
著者所属
値 Division of Child Neurology, Institute of Neurological Sciences, Tottori University Faculty of Medicine
著者所属
値 Department of Child Neurology, National Center Hospital of Neurology and Psychiatry
著者所属
値 Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University
著者所属
値 International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women’s Medical University
著者所属
値 Division of Child Neurology, Institute of Neurological Sciences, Tottori University Faculty of Medicine
抄録
内容記述タイプ Other
内容記述 Colorectal carcinogenesis involves environmental factors and genetic predispositions. Recent studies have suggested the associations between colorectal neoplasm and functional polymorphism of matrix metalloproteinases (MMPs) and cytokine genes. In this study, we analyzed polymorphisms of MMPs and tumor necrosis factor (TNF)-alpha genes, focusing on the susceptibility to colorectal neoplasm and the tumor progression. The subjects were 186 patients (95 men and 91 women) who underwent total colonoscopy, and were classified into cancer, adenoma and non-neoplasm (control) groups of 47, 72 and 67 patients, respectively. The polymorphisms at the MMP-2 ?1306C/T, MMP-3 ?1171 5A/6A, MMP-7 ?181A/G, MMP-9 ?1562C/T and TNF-alpha ?308G/A loci were analyzed. Regarding background factors, significant differences were found in the age, sex ratio and alcohol-drinking and cigarette-smoking histories in the adenoma and cancer groups, compared to those in the control group. On these factors-adjusted logistic regression analysis of polymorphisms and disease susceptibility, no significant difference was noted in the frequency of any polymorphism in the adenoma and cancer groups, compared to those in the control group. The analysis of the involvement of polymorphisms in tumor progression in the adenoma and cancer groups revealed that the odds ratio for the MMP-3 5A allele was significantly higher in the cancer group (2.74; 95% confidence interval = 1.11?6.74, P = 0.02). The polymorphisms of MMP genes and TNF-alpha genes were not associated with the susceptibility to colorectal neoplasm, but the involvement of the MMP-3 5A allele in the progression of adenoma to cancer was suggested.
書誌情報 Yonago Acta medica
en : Yonago Acta medica

巻 52, 号 1, p. 57-72, 発行日 2009-03
出版者
出版者 Tottori University Faculty of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 13468049
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00892882
権利
権利情報 Yonago Acta medica 編集委員会
情報源
関連名称 Yonago Acta medica. 2009, 52(1), 57-72
著者版フラグ
出版タイプ VoR
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