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Rho-ROCK Expression Predicts the Prognosis in Patients with T3/T4 Gastric Cancer
https://repository.lib.tottori-u.ac.jp/records/5052
https://repository.lib.tottori-u.ac.jp/records/5052bfd8a11a-ef5f-4836-a96e-b6a12220eb62
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
50_009-015.pdf (212.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Rho-ROCK Expression Predicts the Prognosis in Patients with T3/T4 Gastric Cancer | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | gastric carcinoma | |||||
| キーワード | ||||||
| 主題 | prognosis | |||||
| キーワード | ||||||
| 主題 | RhoA | |||||
| キーワード | ||||||
| 主題 | ROCK-1 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | gastric carcinoma | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | prognosis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | RhoA | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | ROCK-1 | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Taniguchi, Kenjiro
× Taniguchi, Kenjiro× Tsujitani, Shunichi× Tokuyasu, Naruo× Naka, Takuji× Tatebe, Shigeru× Kondo, Akira× Ikeguchi, Masahide× Taniguchi, Kenjiro× Tsujitani, Shunichi× Naka, Takuji× Tatebe, Shigeru |
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| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | A small GTPase Rho protein and an effector ROCK have significant roles in cancer adhsion, metastasis, invasion, angiogenesis and cell mortality. We investigated the expressions of RhoA protein and ROCK-1 protein in 100 patients with macroscopically T3/T4 gastric cancer immunohistochemically. The expression of RhoA was detected in gastric cancer specimens from 39 patients and that of ROCK-1 in specimens from 30 patients. The clinicopathological characteristics of 21 tumors with co-expression of RhoA and ROCK-1 proteins (Rho/ROCK ON) were compared with those of the 79 remaining tumors (Rho/ROCK OFF). The percentage of lymph node metastasis positive cases in the Rho/ROCK ON group (81%) was higher than that in the Rho/ROCK OFF group (66%), but the difference was not significant (P = 0.183). However, the prognosis of the 21 patients with Rho/ROCK ON was significantly poorer than that of the 79 with Rho/ROCK OFF (P = 0.006). Our results indicate that the evaluation of the protein expression of RhoA and ROCK-1 is useful for predicting the prognosis in patients with T3/T4 gastric cancer. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 50, 号 1, p. 9-15, 発行日 2007-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2007, 50(1), 9-15 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
