| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-06-22 |
| タイトル |
|
|
タイトル |
Rho-ROCK Expression Predicts the Prognosis in Patients with T3/T4 Gastric Cancer |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
gastric carcinoma |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
prognosis |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
RhoA |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
ROCK-1 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
gastric carcinoma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
prognosis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
RhoA |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ROCK-1 |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
Taniguchi, Kenjiro
Tsujitani, Shunichi
Tokuyasu, Naruo
Naka, Takuji
Tatebe, Shigeru
Kondo, Akira
Ikeguchi, Masahide
Taniguchi, Kenjiro
Tsujitani, Shunichi
Naka, Takuji
Tatebe, Shigeru
|
| 著者所属 |
|
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
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|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
A small GTPase Rho protein and an effector ROCK have significant roles in cancer adhsion, metastasis, invasion, angiogenesis and cell mortality. We investigated the expressions of RhoA protein and ROCK-1 protein in 100 patients with macroscopically T3/T4 gastric cancer immunohistochemically. The expression of RhoA was detected in gastric cancer specimens from 39 patients and that of ROCK-1 in specimens from 30 patients. The clinicopathological characteristics of 21 tumors with co-expression of RhoA and ROCK-1 proteins (Rho/ROCK ON) were compared with those of the 79 remaining tumors (Rho/ROCK OFF). The percentage of lymph node metastasis positive cases in the Rho/ROCK ON group (81%) was higher than that in the Rho/ROCK OFF group (66%), but the difference was not significant (P = 0.183). However, the prognosis of the 21 patients with Rho/ROCK ON was significantly poorer than that of the 79 with Rho/ROCK OFF (P = 0.006). Our results indicate that the evaluation of the protein expression of RhoA and ROCK-1 is useful for predicting the prognosis in patients with T3/T4 gastric cancer. |
| 書誌情報 |
Yonago Acta medica
en : Yonago Acta medica
巻 50,
号 1,
p. 9-15,
発行日 2007-03
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| 出版者 |
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|
出版者 |
Tottori University Faculty of Medicine |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13468049 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00892882 |
| 権利 |
|
|
権利情報 |
Yonago Acta medica 編集委員会 |
| 情報源 |
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関連名称 |
Yonago Acta medica. 2007, 50(1), 9-15 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
50_009-015.pdf (212.2 kB)
