| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-06-22 |
| タイトル |
|
|
タイトル |
Biotransformation of Bile Acids by Bacteroides sp. Strain T-40 Isolated from Human Microflora |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Bacteroides |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
bile acid |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
biotransformation |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
dehydrogenase |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
hydrolase |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Bacteroides |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
bile acid |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
biotransformation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
dehydrogenase |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hydrolase |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
Ogura, Yoshio
Takei, Tsuyoshi
Suzuki, Takao
Yamaga, Nobuo
Itoh, Kikuji
Yamada, Kazuo
Ogura, Yoshio
Takei, Tsuyoshi
Suzuki, Takao
Yamaga, Nobuo
Itoh, Kikuji
Yamada, Kazuo
|
| 著者所属 |
|
|
値 |
Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Division of Functional Radiation Science, Research Center for BioScience and Technology, Tottori University |
| 著者所属 |
|
|
値 |
Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Laboratory of Veterinary Public Health, Graduate School of Agricultural and Life Sciences, The University of Tokyo |
| 著者所属 |
|
|
値 |
Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
The effects of Bacteroides sp. strain T-40 isolated from human feces on the biotransformation of bile acids were examined in an anaerobic culture system. Bacteroides sp. T-40 oxidized cholic acid (CA) and chenodeoxycholic acid (CDCA) to 3α,12α-dihydroxy-7-oxo-5β-cholanoic acid and 3α-hydroxy-7-oxo-5β-cholanoic acid, and reduced these oxo-bile acids to CA and CDCA, respectively. However, the reduction activities were lower than the oxidation activities. Hyocholic acid was dehydrogenated, but to a lesser extent than CA or CDCA. On the other hand, α-muricholic acid, which has a hydroxyl group at the position of 7α, was not dehydrogenated. Glycocholic acid was converted to free 3α,12α-dihydroxy-7-oxo-5β-cholanoic acid but any glycine conjugated 7-oxo product was not detected. These data indicate that Bacteroides sp. T-40 possesses bile acid hydrolase and 7α-hydroxysteroid dehydrogenase, by which conjugated bile acids are initially deconjugated, and then undergo oxidization of the 7α-hydroxy group. |
| 書誌情報 |
Yonago Acta medica
en : Yonago Acta medica
巻 50,
号 2,
p. 33-40,
発行日 2007-06
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| 出版者 |
|
|
出版者 |
Tottori University Faculty of Medicine |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13468049 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00892882 |
| 権利 |
|
|
権利情報 |
Yonago Acta medica 編集委員会 |
| 情報源 |
|
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|
関連名称 |
Yonago Acta medica. 2007, 50(2), 33-40 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
50_033-040.pdf (479.2 kB)
