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Biotransformation of Bile Acids by Bacteroides sp. Strain T-40 Isolated from Human Microflora
https://repository.lib.tottori-u.ac.jp/records/5055
https://repository.lib.tottori-u.ac.jp/records/505517327ff8-ab72-474c-b018-7c8d62506842
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
50_033-040.pdf (479.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Biotransformation of Bile Acids by Bacteroides sp. Strain T-40 Isolated from Human Microflora | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Bacteroides | |||||
| キーワード | ||||||
| 主題 | bile acid | |||||
| キーワード | ||||||
| 主題 | biotransformation | |||||
| キーワード | ||||||
| 主題 | dehydrogenase | |||||
| キーワード | ||||||
| 主題 | hydrolase | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Bacteroides | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | bile acid | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | biotransformation | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | dehydrogenase | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | hydrolase | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Ogura, Yoshio
× Ogura, Yoshio× Takei, Tsuyoshi× Suzuki, Takao× Yamaga, Nobuo× Itoh, Kikuji× Yamada, Kazuo× Ogura, Yoshio× Takei, Tsuyoshi× Suzuki, Takao× Yamaga, Nobuo× Itoh, Kikuji× Yamada, Kazuo |
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| 著者所属 | ||||||
| 値 | Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Functional Radiation Science, Research Center for BioScience and Technology, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Laboratory of Veterinary Public Health, Graduate School of Agricultural and Life Sciences, The University of Tokyo | |||||
| 著者所属 | ||||||
| 値 | Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The effects of Bacteroides sp. strain T-40 isolated from human feces on the biotransformation of bile acids were examined in an anaerobic culture system. Bacteroides sp. T-40 oxidized cholic acid (CA) and chenodeoxycholic acid (CDCA) to 3α,12α-dihydroxy-7-oxo-5β-cholanoic acid and 3α-hydroxy-7-oxo-5β-cholanoic acid, and reduced these oxo-bile acids to CA and CDCA, respectively. However, the reduction activities were lower than the oxidation activities. Hyocholic acid was dehydrogenated, but to a lesser extent than CA or CDCA. On the other hand, α-muricholic acid, which has a hydroxyl group at the position of 7α, was not dehydrogenated. Glycocholic acid was converted to free 3α,12α-dihydroxy-7-oxo-5β-cholanoic acid but any glycine conjugated 7-oxo product was not detected. These data indicate that Bacteroides sp. T-40 possesses bile acid hydrolase and 7α-hydroxysteroid dehydrogenase, by which conjugated bile acids are initially deconjugated, and then undergo oxidization of the 7α-hydroxy group. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 50, 号 2, p. 33-40, 発行日 2007-06 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2007, 50(2), 33-40 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
