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Cardiac Preconditioning by Anesthetic Agents: Roles of Volatile Anesthetics and Opioids in Cardioprotection
https://repository.lib.tottori-u.ac.jp/records/5057
https://repository.lib.tottori-u.ac.jp/records/5057cd76a298-b295-4bc6-a931-6b424785b668
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
50_045-055.pdf (432.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Cardiac Preconditioning by Anesthetic Agents: Roles of Volatile Anesthetics and Opioids in Cardioprotection | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | ATP-sensitive potassium channel | |||||
| キーワード | ||||||
| 主題 | ischemic preconditioning | |||||
| キーワード | ||||||
| 主題 | pharmacological preconditioning | |||||
| キーワード | ||||||
| 主題 | volatile anesthetic | |||||
| キーワード | ||||||
| 主題 | opioid | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | ATP-sensitive potassium channel | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | ischemic preconditioning | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | pharmacological preconditioning | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | volatile anesthetic | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | opioid | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Inagaki, Yoshimi
× Inagaki, Yoshimi |
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| 著者所属 | ||||||
| 値 | Division of Anesthesiology and Critical Care Medicine, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Cardiac preconditioning is the most potent and consistently reproducible method of protecting heart tissue against myocardial ischemia-reperfusion injury. This review discussed about the signaling and amplification cascades from either ischemic preconditioning stimulus or pharmacological preconditioning stimulus, the putative end-effectors and the mechanisms involved in cellular protection. The pharmacological preconditioning induced by volatile anesthetics and opioids is very similar to the ischemic preconditioning. It includes activation of G-protein-coupled receptors, multiple protein kinases and ATP-sensitive potassium channels (KATP channels). Volatile anesthetics prime the activation of the sarcolemmal and mitochondrial KATP channels, which are the putative end-effectors of preconditioning, by stimulation of adenosine receptors and subsequent activation of protein kinase C (PKC) and by increased formation of nitric oxide and free oxygen radicals. Similarly, opioids activate δ- and κ-opioid receptors leading to activation of PKC. The open state of the mitochondrial KATP channel and sarcolemmal KATP channel ultimately induces cytoprotection by decreasing Ca2+ overload in the cytosol and mitochondria. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 50, 号 3, p. 45-55, 発行日 2007-09 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2007, 50(3), 45-55 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
