{"_buckets": {"deposit": "212b90f3-1b06-4f4f-b8bb-c7a451159179"}, "_deposit": {"created_by": 10, "id": "5066", "owners": [10], "pid": {"revision_id": 0, "type": "depid", "value": "5066"}, "status": "published"}, "_oai": {"id": "oai:repository.lib.tottori-u.ac.jp:00005066", "sets": ["12", "9", "1059"]}, "author_link": ["18702", "18703", "4050", "2346", "18704", "2381", "18705", "18706", "18707"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "37", "bibliographicPageStart": "29", "bibliographicVolumeNumber": "49", "bibliographic_titles": [{"bibliographic_title": "Yonago Acta medica"}, {"bibliographic_title": "Yonago Acta medica", "bibliographic_titleLang": "en"}]}]}, "item_10001_checkbox_27": {"attribute_name": "部局名", "attribute_value_mlt": [{"subitem_checkbox_item": ["i-gakubu"]}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The profibrogenic role of endothelin-1 (ET-1) and angiotensin-II (AT-II) in renal fibrosis remains disputed. We therefore studied the effect of ET-1 and AT-II on rat mesangial cells (CRL-2573), the major source of extracellular matrix proteins in the kidney. ET-1 stimulated DNA synthesis assessed by BrdU uptake in microtiter tetrazolium assay in a dose dependent manner, but AT-II did not. Proliferation of the mesangial cells by ET-1 was suppressed by 15% with BQ123, an endothelin receptor A antagonist, which suggested a significant role of the endothelin receptor A on growth stimulation. In the mesangial cells, ET-1 increased the mRNA expressions of procollagen α1 (I), transforming growth factor-β1, connective tissue growth factor, tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-13 in dose dependent manners, whereas AT-II had exerted no effect on the expression of these mRNAs. These data suggested that ET-1 might be involved in renal fibrosis through the mesangial cell proliferation and/or the increase in fibrogenic cytokines.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Tottori University Faculty of Medicine"}]}, "item_10001_relation_16": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "Yonago Acta medica. 2006, 49(1), 29-37"}]}]}, "item_10001_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Yonago Acta medica　編集委員会"}]}, "item_10001_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00892882", "subitem_source_identifier_type": "NCID"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "13468049", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_text_25": 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University Faculty of Medicine"}, {"subitem_text_value": "Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine"}, {"subitem_text_value": "Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamamoto, Satoru"}], "nameIdentifiers": [{"nameIdentifier": "18702", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koda, Masahiko"}], "nameIdentifiers": [{"nameIdentifier": "18703", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ueki, Masaru"}, {"creatorName": "Ueki, Masaru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4050", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60542256", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60542256"}, {"nameIdentifier": "100000324", "nameIdentifierScheme": "研究者総覧鳥取大学", "nameIdentifierURI": "http://researchers.adm.tottori-u.ac.jp/html/100000324_ja.html"}]}, {"creatorNames": [{"creatorName": "Munemura, Chishio"}, {"creatorName": "Munemura, Chishio", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "2346", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "100000438", "nameIdentifierScheme": "研究者総覧鳥取大学", "nameIdentifierURI": "http://researchers.adm.tottori-u.ac.jp/html/100000438_ja.html"}]}, {"creatorNames": [{"creatorName": "Maeta, Satoko"}], "nameIdentifiers": [{"nameIdentifier": "18704", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murawaki, Yoshikazu"}, {"creatorName": "Murawaki, Yoshikazu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "2381", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90144659", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90144659"}]}, {"creatorNames": [{"creatorName": "Yamamoto, Satoru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "18705", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koda, Masahiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "18706", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maeta, Satoko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "18707", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2009-06-09"}], "displaytype": "detail", 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"endothelin-1", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "extracellular matrix metabolism", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mesangial cell", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Effects of Endothelin-1 and Angiotensin-II on Extracellular Matrix Metabolism in a Rat Mesangial Cell Line, CRL-2573", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Effects of Endothelin-1 and Angiotensin-II on Extracellular Matrix Metabolism in a Rat Mesangial Cell Line, CRL-2573", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "10", "path": ["12", "9", "1059"], "permalink_uri": "https://repository.lib.tottori-u.ac.jp/records/5066", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2018-06-22"}, "publish_date": "2018-06-22", "publish_status": "0", "recid": "5066", "relation": {}, "relation_version_is_last": true, "title": ["Effects of Endothelin-1 and Angiotensin-II on Extracellular Matrix Metabolism in a Rat Mesangial Cell Line, CRL-2573"], "weko_shared_id": -1}