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Effects of Endothelin-1 and Angiotensin-II on Extracellular Matrix Metabolism in a Rat Mesangial Cell Line, CRL-2573
https://repository.lib.tottori-u.ac.jp/records/5066
https://repository.lib.tottori-u.ac.jp/records/50660e499933-ec2f-4c4b-9029-6ddcb034a0da
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-06-22 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effects of Endothelin-1 and Angiotensin-II on Extracellular Matrix Metabolism in a Rat Mesangial Cell Line, CRL-2573 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | angiotensin-II | |||||
キーワード | ||||||
主題 | endothelin-1 | |||||
キーワード | ||||||
主題 | extracellular matrix metabolism | |||||
キーワード | ||||||
主題 | mesangial cell | |||||
キーワード | ||||||
言語 | en | |||||
主題 | angiotensin-II | |||||
キーワード | ||||||
言語 | en | |||||
主題 | endothelin-1 | |||||
キーワード | ||||||
言語 | en | |||||
主題 | extracellular matrix metabolism | |||||
キーワード | ||||||
言語 | en | |||||
主題 | mesangial cell | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
Yamamoto, Satoru
× Yamamoto, Satoru× Koda, Masahiko× Ueki, Masaru× Munemura, Chishio× Maeta, Satoko× Murawaki, Yoshikazu× Yamamoto, Satoru× Koda, Masahiko× Maeta, Satoko |
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著者所属 | ||||||
Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | ||||||
著者所属 | ||||||
Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | ||||||
著者所属 | ||||||
Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | ||||||
著者所属 | ||||||
Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | ||||||
著者所属 | ||||||
Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | ||||||
著者所属 | ||||||
Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | ||||||
抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The profibrogenic role of endothelin-1 (ET-1) and angiotensin-II (AT-II) in renal fibrosis remains disputed. We therefore studied the effect of ET-1 and AT-II on rat mesangial cells (CRL-2573), the major source of extracellular matrix proteins in the kidney. ET-1 stimulated DNA synthesis assessed by BrdU uptake in microtiter tetrazolium assay in a dose dependent manner, but AT-II did not. Proliferation of the mesangial cells by ET-1 was suppressed by 15% with BQ123, an endothelin receptor A antagonist, which suggested a significant role of the endothelin receptor A on growth stimulation. In the mesangial cells, ET-1 increased the mRNA expressions of procollagen α1 (I), transforming growth factor-β1, connective tissue growth factor, tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-13 in dose dependent manners, whereas AT-II had exerted no effect on the expression of these mRNAs. These data suggested that ET-1 might be involved in renal fibrosis through the mesangial cell proliferation and/or the increase in fibrogenic cytokines. | |||||
書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 49, 号 1, p. 29-37, 発行日 2006-03 |
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出版者 | ||||||
出版者 | Tottori University Faculty of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13468049 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00892882 | |||||
権利 | ||||||
権利情報 | Yonago Acta medica 編集委員会 | |||||
情報源 | ||||||
関連名称 | Yonago Acta medica. 2006, 49(1), 29-37 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |