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Racemic Ketamine and S(+)-Ketamine Concentrations in Cerebrospinal Fluid after Epidural and Intravenous Administration in Rabbits
https://repository.lib.tottori-u.ac.jp/records/5079
https://repository.lib.tottori-u.ac.jp/records/5079ad018fd6-ec73-4bc8-b28d-3a3f87bddb0d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
48_033-040.pdf (199.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Racemic Ketamine and S(+)-Ketamine Concentrations in Cerebrospinal Fluid after Epidural and Intravenous Administration in Rabbits | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | analgesia | |||||
| キーワード | ||||||
| 主題 | cerebrospinal fluid | |||||
| キーワード | ||||||
| 主題 | epidural administratin;ketamine | |||||
| キーワード | ||||||
| 主題 | pharmacokinetics | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | analgesia | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | cerebrospinal fluid | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | epidural administratin;ketamine | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | pharmacokinetics | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Adachi, Hiroshi
× Adachi, Hiroshi× Inagaki, Yoshimi× Okazaki, Naoto× Ishibe, Yuichi× Adachi, Hiroshi× Okazaki, Naoto× Ishibe, Yuichi |
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| 著者所属 | ||||||
| 値 | Division of Anesthesiology and Critical Care Medicine, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Anesthesiology and Critical Care Medicine, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Anesthesiology and Critical Care Medicine, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Anesthesiology and Critical Care Medicine, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The pharmacokinetic characteristic of ketamine, particularly the shift from the epidural space to the cerebrospinal fluid (CSF), is still unclear. Furthermore pharmacokinetic differences between racemic ketamine and S(+)-ketamine are not clearly described when administered into the epidural space. We measured plasma and CSF concentrations of racemic ketamine and S(+)-ketamine after 2 mg/kg intravenous or 2 mg/kg epidural injection in 32 rabbits, and calculated pharmacokinetic parameters by the moment analysis method. The elimination half time of S(+)-ketamine was significantly shorter than that of racemic ketamine and the systemic distribution volume of S(+)-ketamine was significantly smaller than that of racemic ketamine in the CSF. Pharmacokinetic parameters in the CSF after epidural injection of racemic versus S(+)-ketamines were: maximum concentration, 0.4 ± 0.1 versus 0.6 ± 0.2 ?g/mL (not significant); time to maximum concentration, 9.7 ± 2.1 versus 9.0 ± 3.4 min (not significant); elimination half time, 127.1 ± 25.2 versus 89.3 ± 19.4 min (P = 0.005); area under the curve, 56.4 ± 6.4 versus 56.6 ± 11.0 ?g?mL/min (not significant); and distribution volume, 19,463.5 ± 3266.1 versus 13,613.3 ± 4895.2 mL (P = 0.014), respectively. When injected intravenously, there was no significant difference in these parameters of the CSF between racemic and S(+)-ketamines. Racemic ketamine passed easily through the blood brain barrier when administered intravenously. It also shifted to the CSF through the systemic circulation, even when they were administered epidurally. S(+)-Ketamine had similar movement as racemic ketamine. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 48, 号 1, p. 33-40, 発行日 2005-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2005, 48(1), 33-40 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
