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Racemic Ketamine and S(+)-Ketamine Concentrations in Cerebrospinal Fluid after Epidural and Intravenous Administration in Rabbits
https://repository.lib.tottori-u.ac.jp/records/5079
https://repository.lib.tottori-u.ac.jp/records/5079ad018fd6-ec73-4bc8-b28d-3a3f87bddb0d
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-06-22 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Racemic Ketamine and S(+)-Ketamine Concentrations in Cerebrospinal Fluid after Epidural and Intravenous Administration in Rabbits | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | analgesia | |||||
キーワード | ||||||
主題 | cerebrospinal fluid | |||||
キーワード | ||||||
主題 | epidural administratin;ketamine | |||||
キーワード | ||||||
主題 | pharmacokinetics | |||||
キーワード | ||||||
言語 | en | |||||
主題 | analgesia | |||||
キーワード | ||||||
言語 | en | |||||
主題 | cerebrospinal fluid | |||||
キーワード | ||||||
言語 | en | |||||
主題 | epidural administratin;ketamine | |||||
キーワード | ||||||
言語 | en | |||||
主題 | pharmacokinetics | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
Adachi, Hiroshi
× Adachi, Hiroshi× Inagaki, Yoshimi× Okazaki, Naoto× Ishibe, Yuichi× Adachi, Hiroshi× Okazaki, Naoto× Ishibe, Yuichi |
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著者所属 | ||||||
Division of Anesthesiology and Critical Care Medicine, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | ||||||
著者所属 | ||||||
Division of Anesthesiology and Critical Care Medicine, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | ||||||
著者所属 | ||||||
Division of Anesthesiology and Critical Care Medicine, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | ||||||
著者所属 | ||||||
Division of Anesthesiology and Critical Care Medicine, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | ||||||
抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The pharmacokinetic characteristic of ketamine, particularly the shift from the epidural space to the cerebrospinal fluid (CSF), is still unclear. Furthermore pharmacokinetic differences between racemic ketamine and S(+)-ketamine are not clearly described when administered into the epidural space. We measured plasma and CSF concentrations of racemic ketamine and S(+)-ketamine after 2 mg/kg intravenous or 2 mg/kg epidural injection in 32 rabbits, and calculated pharmacokinetic parameters by the moment analysis method. The elimination half time of S(+)-ketamine was significantly shorter than that of racemic ketamine and the systemic distribution volume of S(+)-ketamine was significantly smaller than that of racemic ketamine in the CSF. Pharmacokinetic parameters in the CSF after epidural injection of racemic versus S(+)-ketamines were: maximum concentration, 0.4 ± 0.1 versus 0.6 ± 0.2 ?g/mL (not significant); time to maximum concentration, 9.7 ± 2.1 versus 9.0 ± 3.4 min (not significant); elimination half time, 127.1 ± 25.2 versus 89.3 ± 19.4 min (P = 0.005); area under the curve, 56.4 ± 6.4 versus 56.6 ± 11.0 ?g?mL/min (not significant); and distribution volume, 19,463.5 ± 3266.1 versus 13,613.3 ± 4895.2 mL (P = 0.014), respectively. When injected intravenously, there was no significant difference in these parameters of the CSF between racemic and S(+)-ketamines. Racemic ketamine passed easily through the blood brain barrier when administered intravenously. It also shifted to the CSF through the systemic circulation, even when they were administered epidurally. S(+)-Ketamine had similar movement as racemic ketamine. | |||||
書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 48, 号 1, p. 33-40, 発行日 2005-03 |
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出版者 | ||||||
出版者 | Tottori University Faculty of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13468049 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00892882 | |||||
権利 | ||||||
権利情報 | Yonago Acta medica 編集委員会 | |||||
情報源 | ||||||
関連名称 | Yonago Acta medica. 2005, 48(1), 33-40 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |