{"_buckets": {"deposit": "42341d06-a278-47ac-bbde-57af8d40d451"}, "_deposit": {"created_by": 10, "id": "5079", "owners": [10], "pid": {"revision_id": 0, "type": "depid", "value": "5079"}, "status": "published"}, "_oai": {"id": "oai:repository.lib.tottori-u.ac.jp:00005079", "sets": ["12", "9", "1064"]}, "author_link": ["18776", "938", "18777", "18778", "18779", "18780", "18781"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2005-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "40", "bibliographicPageStart": "33", "bibliographicVolumeNumber": "48", "bibliographic_titles": [{"bibliographic_title": "Yonago Acta medica"}, {"bibliographic_title": "Yonago Acta medica", "bibliographic_titleLang": "en"}]}]}, "item_10001_checkbox_27": {"attribute_name": "部局名", "attribute_value_mlt": [{"subitem_checkbox_item": ["i-gakubu"]}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The pharmacokinetic characteristic of ketamine, particularly the shift from the epidural space to the cerebrospinal fluid (CSF), is still unclear. Furthermore pharmacokinetic differences between racemic ketamine and S(+)-ketamine are not clearly described when administered into the epidural space. We measured plasma and CSF concentrations of racemic ketamine and S(+)-ketamine after 2 mg/kg intravenous or 2 mg/kg epidural injection in 32 rabbits, and calculated pharmacokinetic parameters by the moment analysis method. The elimination half time of S(+)-ketamine was significantly shorter than that of racemic ketamine and the systemic distribution volume of S(+)-ketamine was significantly smaller than that of racemic ketamine in the CSF. Pharmacokinetic parameters in the CSF after epidural injection of racemic versus S(+)-ketamines were: maximum concentration, 0.4 ± 0.1 versus 0.6 ± 0.2 ?g/mL (not significant); time to maximum concentration, 9.7 ± 2.1 versus 9.0 ± 3.4 min (not significant); elimination half time, 127.1 ± 25.2 versus 89.3 ± 19.4 min (P = 0.005); area under the curve, 56.4 ± 6.4 versus 56.6 ± 11.0 ?g?mL/min (not significant); and distribution volume, 19,463.5 ± 3266.1 versus 13,613.3 ± 4895.2 mL (P = 0.014), respectively. When injected intravenously, there was no significant difference in these parameters of the CSF between racemic and S(+)-ketamines. Racemic ketamine passed easily through the blood brain barrier when administered intravenously. It also shifted to the CSF through the systemic circulation, even when they were administered epidurally. S(+)-Ketamine had similar movement as racemic ketamine.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Tottori University Faculty of Medicine"}]}, "item_10001_relation_16": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "Yonago Acta medica. 2005, 48(1), 33-40"}]}]}, "item_10001_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Yonago Acta medica　編集委員会"}]}, "item_10001_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00892882", "subitem_source_identifier_type": "NCID"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "13468049", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_text_25": {"attribute_name": "EARMAS ID", "attribute_value_mlt": [{"subitem_text_value": "436"}]}, "item_10001_text_29": {"attribute_name": "最新掲載誌名", "attribute_value_mlt": [{"subitem_text_value": "yam;Yonago Acta medica;Yonago Acta medica"}]}, "item_10001_text_32": {"attribute_name": "著者所属", "attribute_value_mlt": [{"subitem_text_value": "Division of Anesthesiology and Critical Care Medicine, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"}, {"subitem_text_value": "Division of Anesthesiology and Critical Care Medicine, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"}, {"subitem_text_value": "Division of Anesthesiology and Critical Care Medicine, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"}, {"subitem_text_value": "Division of Anesthesiology and Critical Care Medicine, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Adachi, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "18776", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Inagaki, Yoshimi"}, {"creatorName": "Inagaki, Yoshimi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "938", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40184717", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40184717"}, {"nameIdentifier": "100000092", "nameIdentifierScheme": "研究者総覧鳥取大学", "nameIdentifierURI": "http://researchers.adm.tottori-u.ac.jp/html/100000092_ja.html"}]}, {"creatorNames": [{"creatorName": "Okazaki, Naoto"}], "nameIdentifiers": [{"nameIdentifier": "18777", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishibe, Yuichi"}], "nameIdentifiers": [{"nameIdentifier": "18778", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Adachi, Hiroshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "18779", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okazaki, Naoto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "18780", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishibe, Yuichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "18781", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2009-06-09"}], "displaytype": "detail", "download_preview_message": "", 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"subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "epidural administratin;ketamine", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pharmacokinetics", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Racemic Ketamine and S(+)-Ketamine Concentrations in Cerebrospinal Fluid after Epidural and Intravenous Administration in Rabbits", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Racemic Ketamine and S(+)-Ketamine Concentrations in Cerebrospinal Fluid after Epidural and Intravenous Administration in Rabbits", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "10", "path": ["12", "9", "1064"], "permalink_uri": "https://repository.lib.tottori-u.ac.jp/records/5079", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2018-06-22"}, "publish_date": "2018-06-22", "publish_status": "0", "recid": "5079", "relation": {}, "relation_version_is_last": true, "title": ["Racemic Ketamine and S(+)-Ketamine Concentrations in Cerebrospinal Fluid after Epidural and Intravenous Administration in Rabbits"], "weko_shared_id": -1}