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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
  1. 資料タイプ一覧
  2. 学術雑誌論文
  1. 鳥取大学の刊行物
  2. Yonago Acta Medica
  3. 48
  4. 1

Racemic Ketamine and S(+)-Ketamine Concentrations in Cerebrospinal Fluid after Epidural and Intravenous Administration in Rabbits

https://repository.lib.tottori-u.ac.jp/records/5079
https://repository.lib.tottori-u.ac.jp/records/5079
ad018fd6-ec73-4bc8-b28d-3a3f87bddb0d
名前 / ファイル ライセンス アクション
48_033-040.pdf 48_033-040.pdf (199.0 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-06-22
タイトル
タイトル Racemic Ketamine and S(+)-Ketamine Concentrations in Cerebrospinal Fluid after Epidural and Intravenous Administration in Rabbits
言語 en
言語
言語 eng
キーワード
主題 analgesia
キーワード
主題 cerebrospinal fluid
キーワード
主題 epidural administratin;ketamine
キーワード
主題 pharmacokinetics
キーワード
言語 en
主題 analgesia
キーワード
言語 en
主題 cerebrospinal fluid
キーワード
言語 en
主題 epidural administratin;ketamine
キーワード
言語 en
主題 pharmacokinetics
資源タイプ
資源タイプ journal article
著者 Adachi, Hiroshi

× Adachi, Hiroshi

WEKO 18776

Adachi, Hiroshi

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Inagaki, Yoshimi

× Inagaki, Yoshimi

WEKO 938
e-Rad 40184717
研究者総覧鳥取大学 100000092

Inagaki, Yoshimi

en Inagaki, Yoshimi

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Okazaki, Naoto

× Okazaki, Naoto

WEKO 18777

Okazaki, Naoto

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Ishibe, Yuichi

× Ishibe, Yuichi

WEKO 18778

Ishibe, Yuichi

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Adachi, Hiroshi

× Adachi, Hiroshi

WEKO 18779

en Adachi, Hiroshi

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Okazaki, Naoto

× Okazaki, Naoto

WEKO 18780

en Okazaki, Naoto

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Ishibe, Yuichi

× Ishibe, Yuichi

WEKO 18781

en Ishibe, Yuichi

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著者所属
値 Division of Anesthesiology and Critical Care Medicine, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Division of Anesthesiology and Critical Care Medicine, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Division of Anesthesiology and Critical Care Medicine, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Division of Anesthesiology and Critical Care Medicine, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
抄録
内容記述タイプ Other
内容記述 The pharmacokinetic characteristic of ketamine, particularly the shift from the epidural space to the cerebrospinal fluid (CSF), is still unclear. Furthermore pharmacokinetic differences between racemic ketamine and S(+)-ketamine are not clearly described when administered into the epidural space. We measured plasma and CSF concentrations of racemic ketamine and S(+)-ketamine after 2 mg/kg intravenous or 2 mg/kg epidural injection in 32 rabbits, and calculated pharmacokinetic parameters by the moment analysis method. The elimination half time of S(+)-ketamine was significantly shorter than that of racemic ketamine and the systemic distribution volume of S(+)-ketamine was significantly smaller than that of racemic ketamine in the CSF. Pharmacokinetic parameters in the CSF after epidural injection of racemic versus S(+)-ketamines were: maximum concentration, 0.4 ± 0.1 versus 0.6 ± 0.2 ?g/mL (not significant); time to maximum concentration, 9.7 ± 2.1 versus 9.0 ± 3.4 min (not significant); elimination half time, 127.1 ± 25.2 versus 89.3 ± 19.4 min (P = 0.005); area under the curve, 56.4 ± 6.4 versus 56.6 ± 11.0 ?g?mL/min (not significant); and distribution volume, 19,463.5 ± 3266.1 versus 13,613.3 ± 4895.2 mL (P = 0.014), respectively. When injected intravenously, there was no significant difference in these parameters of the CSF between racemic and S(+)-ketamines. Racemic ketamine passed easily through the blood brain barrier when administered intravenously. It also shifted to the CSF through the systemic circulation, even when they were administered epidurally. S(+)-Ketamine had similar movement as racemic ketamine.
書誌情報 Yonago Acta medica
en : Yonago Acta medica

巻 48, 号 1, p. 33-40, 発行日 2005-03
出版者
出版者 Tottori University Faculty of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 13468049
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00892882
権利
権利情報 Yonago Acta medica 編集委員会
情報源
関連名称 Yonago Acta medica. 2005, 48(1), 33-40
著者版フラグ
出版タイプ VoR
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