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Regulation of TNF-α, IL-1β and ICAM-1 Gene Expression in THP-1 Monocytes Stimulated with Plasmodium falciparum-Cultured Medium by Excretory/Secretory Products from Spirometra erinaceieuropaei Plerocercoids
https://repository.lib.tottori-u.ac.jp/records/5088
https://repository.lib.tottori-u.ac.jp/records/5088b4298a3f-ddff-4804-a643-6cc83c94f123
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
47_007-015.pdf (79.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Regulation of TNF-α, IL-1β and ICAM-1 Gene Expression in THP-1 Monocytes Stimulated with Plasmodium falciparum-Cultured Medium by Excretory/Secretory Products from Spirometra erinaceieuropaei Plerocercoids | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | human monocytes | |||||
| キーワード | ||||||
| 主題 | mitogen-activated protein kinase | |||||
| キーワード | ||||||
| 主題 | Plasmodium falciparum | |||||
| キーワード | ||||||
| 主題 | Spirometra erinaceieuropaei | |||||
| キーワード | ||||||
| 主題 | tumor necrosis factor-α | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | human monocytes | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | mitogen-activated protein kinase | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Plasmodium falciparum | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Spirometra erinaceieuropaei | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | tumor necrosis factor-α | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Dirgahayu, Paramasari
× Dirgahayu, Paramasari× Fukumoto, Soji× Tademoto, Sayuri× Hirai, Kazumitsu× Dirgahayu, Paramasari× Tademoto, Sayuri |
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| 著者所属 | ||||||
| 値 | Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | We have reported that excretory/secretory (ES) products from Spirometra erinaceieuropaei plerocercoids suppress production and gene expression of tumor necrosis factor (TNF)-α in murine macrophages stimulated with lipopolysaccharide. The present study demonstrates that ES products suppress TNF-α, interleukin (IL)-1β and intercellular adhesion molecule (ICAM)-1 gene expression in human monocytic leukemia cell line THP-1 stimulated with Plasmodium falciparum-cultured medium (Pf-CM). Inhibition of extracellular-signal regulated protein kinase 1/2 (ERK1/2) with PD98059 reduced TNF-α, IL-1β and ICAM-1 gene expression; on the contrary inhibition of p38 mitogen-activated protein kinase (MAPK) with SB203580 increased the expression of these genes. These findings indicated that ERK1/2, but not p38 MAPK pathway is important for induction of TNF-α, IL-1β and ICAM-1 gene expression in Pf-CM stimulated THP-1 monocytes. ES products additionally suppress IL-1β, but not TNF-α and ICAM-1 gene expression in Pf-CM stimulated THP-1 cells treated with PD98059. We hypothesize that ES products may be useful in reducing falciparum malaria-induced inflammatory response and sequestration in the late stage of malarial diseases such as cerebral malaria. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 47, 号 1, p. 7-15, 発行日 2004-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2004, 47(1), 7-15 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
