| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-06-22 |
| タイトル |
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|
タイトル |
Regulation of TNF-α, IL-1β and ICAM-1 Gene Expression in THP-1 Monocytes Stimulated with Plasmodium falciparum-Cultured Medium by Excretory/Secretory Products from Spirometra erinaceieuropaei Plerocercoids |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
human monocytes |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
mitogen-activated protein kinase |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Plasmodium falciparum |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Spirometra erinaceieuropaei |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
tumor necrosis factor-α |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
human monocytes |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
mitogen-activated protein kinase |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Plasmodium falciparum |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Spirometra erinaceieuropaei |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
tumor necrosis factor-α |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
Dirgahayu, Paramasari
Fukumoto, Soji
Tademoto, Sayuri
Hirai, Kazumitsu
Dirgahayu, Paramasari
Tademoto, Sayuri
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| 著者所属 |
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|
値 |
Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
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|
値 |
Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
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|
値 |
Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
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|
値 |
Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine |
| 抄録 |
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内容記述タイプ |
Other |
|
内容記述 |
We have reported that excretory/secretory (ES) products from Spirometra erinaceieuropaei plerocercoids suppress production and gene expression of tumor necrosis factor (TNF)-α in murine macrophages stimulated with lipopolysaccharide. The present study demonstrates that ES products suppress TNF-α, interleukin (IL)-1β and intercellular adhesion molecule (ICAM)-1 gene expression in human monocytic leukemia cell line THP-1 stimulated with Plasmodium falciparum-cultured medium (Pf-CM). Inhibition of extracellular-signal regulated protein kinase 1/2 (ERK1/2) with PD98059 reduced TNF-α, IL-1β and ICAM-1 gene expression; on the contrary inhibition of p38 mitogen-activated protein kinase (MAPK) with SB203580 increased the expression of these genes. These findings indicated that ERK1/2, but not p38 MAPK pathway is important for induction of TNF-α, IL-1β and ICAM-1 gene expression in Pf-CM stimulated THP-1 monocytes. ES products additionally suppress IL-1β, but not TNF-α and ICAM-1 gene expression in Pf-CM stimulated THP-1 cells treated with PD98059. We hypothesize that ES products may be useful in reducing falciparum malaria-induced inflammatory response and sequestration in the late stage of malarial diseases such as cerebral malaria. |
| 書誌情報 |
Yonago Acta medica
en : Yonago Acta medica
巻 47,
号 1,
p. 7-15,
発行日 2004-03
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| 出版者 |
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出版者 |
Tottori University Faculty of Medicine |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13468049 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00892882 |
| 権利 |
|
|
権利情報 |
Yonago Acta medica 編集委員会 |
| 情報源 |
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関連名称 |
Yonago Acta medica. 2004, 47(1), 7-15 |
| 著者版フラグ |
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出版タイプ |
VoR |
47_007-015.pdf (79.2 kB)
