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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
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  2. 学術雑誌論文
  1. 鳥取大学の刊行物
  2. Yonago Acta Medica
  3. 46
  4. 4

Changes in Apoptosis-Related Genes (Bcl-2, Bax) in the Urethras of Old Female Rats Following Estrogen Replacement

https://repository.lib.tottori-u.ac.jp/records/5112
https://repository.lib.tottori-u.ac.jp/records/5112
667d2d96-26ed-4c74-b0b8-819a434881c4
名前 / ファイル ライセンス アクション
46_109-115.pdf 46_109-115.pdf (134.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-06-22
タイトル
タイトル Changes in Apoptosis-Related Genes (Bcl-2, Bax) in the Urethras of Old Female Rats Following Estrogen Replacement
言語 en
言語
言語 eng
キーワード
主題 apoptosis
キーワード
主題 estrogen replacement
キーワード
主題 old rat
キーワード
主題 urethra
キーワード
言語 en
主題 apoptosis
キーワード
言語 en
主題 estrogen replacement
キーワード
言語 en
主題 old rat
キーワード
言語 en
主題 urethra
資源タイプ
資源タイプ journal article
著者 Kinouchi, Shinichiro

× Kinouchi, Shinichiro

WEKO 18956

Kinouchi, Shinichiro

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Kinouchi, Shinichiro

× Kinouchi, Shinichiro

WEKO 18957

en Kinouchi, Shinichiro

Search repository
著者所属
値 Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
抄録
内容記述タイプ Other
内容記述 Following estrogen replacement in old female rats, changes in apoptosis-related genes (Bcl-2, Bax) in the urethra were investigated by immunohistochemical and RT-PCR analysis. A total of 40 old (16-month-old) female Wistar rats were divided into the following 5 groups: normal controls; rats replaced with low-dose estradiol (E2) for 2 and 4 weeks, respectively; and rats replaced with high-dose E2 for 2 and 4 weeks, respectively. After treatment, the urethras were removed, weighed and stained with hematoxylin and eosin, and then immunohistochemical stainings of Bcl-2 and Bax were performed. In addition,the expressions of the apoptosis-related genes bcl-2 and bax were investigated by PCR analysis, and then evaluated by computerized quantification. In the E2-replaced rats, the immunostained urethras showed little immunoreactivity against the Bcl-protein, and inthe control rats, no reactivity was seen. In contrast, the control rats showedimmunoreactivity against the Bax protein, whereas the E2-replaced rats showed little reactivity. Upon mRNA analysis, the expression of bcl-2 mRNA was uprisen in rats in the high-dose E2 for 4 weeks group as compared with the controls, but the expression of bax mRNA was suppressed in the E2-replaced rats as compared with the controls. As these results suggest, estrogen replacement up-regulated the expression of bcl-2 mRNA and down-regulated the expression of bax mRNA, which might suppress the apoptic action: these changes might alter lower urinary tract findings.
書誌情報 Yonago Acta medica
en : Yonago Acta medica

巻 46, 号 4, p. 109-115, 発行日 2003-12
出版者
出版者 Tottori University Faculty of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 13468049
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00892882
権利
権利情報 Yonago Acta medica 編集委員会
情報源
関連名称 Yonago Acta medica. 2003, 46(4), 109-115
著者版フラグ
出版タイプ VoR
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