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Effects of Estrogen Replacement Therapy on the Expression of Apoptosis-Related Genes in Old Female Rats
https://repository.lib.tottori-u.ac.jp/records/5127
https://repository.lib.tottori-u.ac.jp/records/51276193fd66-a147-4f8d-b171-be2e0e33824f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
45_095-102.pdf (61.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Effects of Estrogen Replacement Therapy on the Expression of Apoptosis-Related Genes in Old Female Rats | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | apoptosis | |||||
| キーワード | ||||||
| 主題 | bladder | |||||
| キーワード | ||||||
| 主題 | estrogen | |||||
| キーワード | ||||||
| 主題 | rat | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | apoptosis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | bladder | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | estrogen | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | rat | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Ohata, Ryo
× Ohata, Ryo× Ohata, Ryo |
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| 著者所属 | ||||||
| 値 | Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Effects of estradiol (E2) on the urinary bladder of old female rats were investigated by morphological, immunohistochemical and apoptosis-related gene analysis. Sixteen-month-old female Wistar rats were divided into the following 5 groups: normal controls; rats replaced with low-dose E2 for 2 and 4 weeks, respectively; and rats replaced with high-dose E2 for 2 and 4 weeks, respectively. After treatment, the bladders were removed, weighed and stained with hematoxylin and eosin, and immunostained by monoclonal antibodies against Bcl-2 and Bax proteins. Further, the expression of apoptosis-related genes bcl-2 and bax were investigated by PCR analysis, and evaluated by computerized quantification. Immunostained bladders showed no difference between control and E2-replaced rats in reactivity against Bcl-2 protein. In contrast, against Bax protein, control rats showed immunoreactivity, whereas E2-replaced rats showed little reactivity. Upon mRNA analysis, the expression of bax mRNA was suppressed in the E2-replaced rats as compared with the controls, though the expression of bcl-2 mRNA showed no difference among groups. These results suggest that E2 administration affects the expression of apoptosis-related genes and suppressees apoptotic action, and that these changes could consequently alter voiding behavior. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 45, 号 4, p. 95-102, 発行日 2002-12 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892883 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2002, 45(3), 95-102 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
