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Immunohistochemical Study of Dendritic Cells and Kupffer Cells in Griseofulvin-Induced Protoporphyric Mice
https://repository.lib.tottori-u.ac.jp/records/5132
https://repository.lib.tottori-u.ac.jp/records/5132678503f5-6e81-4a23-a386-3af3066c084d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
44_007-016.pdf (344.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Immunohistochemical Study of Dendritic Cells and Kupffer Cells in Griseofulvin-Induced Protoporphyric Mice | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | dendritic cell | |||||
| キーワード | ||||||
| 主題 | griseofulvin | |||||
| キーワード | ||||||
| 主題 | immunohistochemistry | |||||
| キーワード | ||||||
| 主題 | Kupffer cell | |||||
| キーワード | ||||||
| 主題 | protoporphyria | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | dendritic cell | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | griseofulvin | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | immunohistochemistry | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Kupffer cell | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | protoporphyria | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Kashiwagi, Ryota
× Kashiwagi, Ryota× Kaidoh, Toshiyuki× Inoue, Takao× Kashiwagi, Ryota |
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| 著者所属 | ||||||
| 値 | Second Department of Anatomy, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Second Department of Anatomy, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Second Department of Anatomy, Faculty of Medicine, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | To determine whether protoporphyric liver injury affects hepatic dendritic cells (DC) and Kupffer cells, we examined liver tissues of griseofulvin-induced protoporphyric mice using histological and immunohistochemical methods. After 1 week of griseofulvin feeding, the protoporphyric liver showed prominent hepatomegaly and a gradual increase in histopathological changes such as hepatocellular hypertrophy, focal necrosis and brown pigment deposits. After 4 weeks of treatment, marked ductular reaction was observed in the liver tissue. Immunohistochemical analyses indicated that the density of NLDC-145-positive hepatic DC gradually decreased during griseofulvin feeding. However, the index of the number of DC in the whole liver appeared to fall sharply after 6 weeks. In contrast, the density of F4/80-positive Kupffer cells gradually increased during griseofulvin feeding. In the spleen and lung, no significant differences were noted in the distribution of NLDC-145-positive DC between experimental and control mice. These results suggested that griseofulvin-induced protoporphyria leads to a specific decrease in the density of hepatic DC due to hepatomegaly until 4 weeks of treatment and is substantial after 6 weeks. This substantial decrease of hepatic DC might have been induced by some alterations in protoporphyric liver injury including ductular reaction at a later stage in this experiment. Since hepatic DC were reduced in number, they seemed to have no significant relation to the progression of griseofulvin-induced protoporphyric liver injury. However, the decrease of hepatic DC might affect the cellular immune response in protoporphyria. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 44, 号 1, p. 7-16, 発行日 2001-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2001, 44(1), 7-16 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
