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Effect of Partial Ileal Bypass on Cholesterol and Bile Acid Metabolism in Rats
https://repository.lib.tottori-u.ac.jp/records/5139
https://repository.lib.tottori-u.ac.jp/records/5139fad42b72-31f4-4e5a-93ee-18fd2d48766a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
44_069-077.pdf (176.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Effect of Partial Ileal Bypass on Cholesterol and Bile Acid Metabolism in Rats | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | biliary lipids | |||||
| キーワード | ||||||
| 主題 | fecal bile acids | |||||
| キーワード | ||||||
| 主題 | fecal sterols | |||||
| キーワード | ||||||
| 主題 | ileal bypass rat | |||||
| キーワード | ||||||
| 主題 | serum and liver lipids | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | biliary lipids | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | fecal bile acids | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | fecal sterols | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | ileal bypass rat | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | serum and liver lipids | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Uchida, Kiyohisa
× Uchida, Kiyohisa× Satoh, Takashi× Ogura, Yoshio× Yamaga, Nobuo× Yamada, Kazuo× Uchida, Kiyohisa× Satoh, Takashi× Ogura, Yoshio× Yamaga, Nobuo× Yamada, Kazuo |
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| 著者所属 | ||||||
| 値 | Department of Biochemistry, Tottori University Faculty of Medicine, The Cell Science Research Foundation | |||||
| 著者所属 | ||||||
| 値 | Shionogi & Co., Ltd. | |||||
| 著者所属 | ||||||
| 値 | Department of Biochemistry, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Biochemistry, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Biochemistry, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | In order to clarify the effect of ileal bypass on cholesterol and bile acid metabolism, partial (20 cm) ileal bypass rats were fed a 2% cholesterol supplemented diet for a week after 4 weeks of the operation. The serum and liver cholesterol and phospholipid levels, biliary cholesterol, phospholipid and bile acid secretions, and fecal cholesterol, coprostanol and bile acid excretions were examined. The serum cholesterol level in ileal bypass rats was lower than in normal rats and no hypercholesterolemia was brought about in ileal bypass rats by feeding them the cholesterol diet. The liver cholesterol level increased by feeding the cholesterol diet even in ileal bypass rats but the increase was far less than that in normal rats (22% versus 57%). Biliary bile acid secretion decreased and fecal bile acid excretion increased markedly in ileal bypass rats. Deoxycholic acid increased remarkably in both bile and feces and resulted in an increase in the ratio of the sum of bile acids derived from cholic acid over the sum of bile acids derived from chenodeoxycholic acid (CA/CDCA ratio) in the feces. These results suggest that the absorption of bile acids is impaired, the pool size of bile acids decreases and the hepatic synthesis of bile acids, especially that of cholic acid, increases in ileal bypass rats. As a result, cholesterol feeding to ileal bypass rats produces neither hypercholesterolemia nor a further increase in bile acid synthesis. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 44, 号 1, p. 69-77, 発行日 2001-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2001, 44(1), 69-77 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
