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Frequent Mutations in the β-Catenin Gene in Cholangiocarcinoma
https://repository.lib.tottori-u.ac.jp/records/5143
https://repository.lib.tottori-u.ac.jp/records/514338d054de-3123-40bd-9688-cb2e5b70869d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
44_107-114.pdf (98.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Frequent Mutations in the β-Catenin Gene in Cholangiocarcinoma | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | β-catenin | |||||
| キーワード | ||||||
| 主題 | cholangiocarcinoma | |||||
| キーワード | ||||||
| 主題 | deletion | |||||
| キーワード | ||||||
| 主題 | exon 3 | |||||
| キーワード | ||||||
| 主題 | mutation | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | β-catenin | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | cholangiocarcinoma | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | deletion | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | exon 3 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | mutation | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Miyake, Noriko
× Miyake, Noriko× Endo, Kanenori× Nanba, Eiji× Terada, Tadashi× Miyake, Noriko× Endo, Kanenori× Terada, Tadashi |
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| 著者所属 | ||||||
| 値 | Second Department of Pathology, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Second Department of Pathology, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Gene Research Center, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Second Department of Pathology, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The molecular pathogenesis of cholangiocarcinoma (CC) remains unclear. β-Catenin functions in both intercellular adhesion and signal transduction. As a signaling molecule, mutations in exon 3 of the β-catenin gene encoding the regions phosphorylated by glycogen synthase kinase (GSK)-3β stabilize this protein in cytoplasm. Subsequently, accumulated β-catenin protein translocates to nuclei and up-regulates the transcriptional activity of genes involved in oncogenesis. Recently, mutations in exon 3 of the β-catenin gene were detected in various carcinomas. Using polymerase chain reaction (PCR)-single-strand conformational polymorphism (SSCP) analysis, direct sequencing and subcloning-sequencing, we investigated mutations of exon 3 of the β-catenin gene in CC. Mutations were found in 26 out of 33 (78.8%) CC tumor samples. All of the mutations were heterozygous 1-base deletions at codon 15, resulting in a stop codon at codon 46. This is the first study demonstrating the presence of β-catenin gene mutations in CC. However, it was suggested that this mutation might not be involved in deregulation of β-catenin signaling, because no correlation was observed between the β-catenin mutation and immunolocalization of β-catenin protein. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 44, 号 2, p. 107-114, 発行日 2001-07 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2001, 44(2), 107-114 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
