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Apoptotic Cell Death and p53 Expression in Leiomyosarcoma of Soft-Tissue Origin
https://repository.lib.tottori-u.ac.jp/records/5144
https://repository.lib.tottori-u.ac.jp/records/51444371eaf3-583a-464c-9132-716873e441da
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
44_115-123.pdf (441.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Apoptotic Cell Death and p53 Expression in Leiomyosarcoma of Soft-Tissue Origin | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | apoptosis/immunohistochemistry/leiomyosarcoma/p53 protein | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | apoptosis/immunohistochemistry/leiomyosarcoma/p53 protein | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Yoshida, Haruhiko
× Yoshida, Haruhiko× Watanabe, Mari× Shomori, Kohei× Ito, Hisao× Minamizaki, Takeshi× Watanabe, Mari× Minamizaki, Takeshi |
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| 著者所属 | ||||||
| 値 | Department of Pathobiological Science and Technology, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | First Department of Pathology, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | First Department of Pathology, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | First Department of Pathology, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Orthopaedic Surgery, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Leiomyosarcoma (LMS) of soft-tissue origin was studied on the expression and the biological significance of apoptosis in relation to p53 oncoprotein. Immunohistochemical analysis was performed initially on the paraffin-embbeded sections taken from 29 surgical tissues (20 cases) including 9 recurrent/metastatic tumors. The results are as follows: A positive correlation was observed between the p53 indices (PIs) and the proliferative markers designated by Ki-67, PCNA and MCM2, both of which increased significantly in the high-grade malignant LMS much more than in the low-grade one (P < 0.001). Apoptotic cells were detected by the TUNEL method and evaluated as the apoptotic index (AI). A high AI-level was shown in the high-grade malignant LMS, especially in cases of the recurrent/metastatic sites in comparison with the tumors of the primary site (P < 0.05). The AI was statistically higher in the p53-positive cases of high-grade malignant LMS than in the p53-negative cases of low-grade malignant LMS. In conclusion, apoptotic activity paralleled the overexpression of p53 protein along with an increasing grade of malignancy and may be related intimately to the increased malignant potential, especially to recurrence/metastasis. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 44, 号 2, p. 115-123, 発行日 2001-07 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2001, 44(2), 115-123 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
