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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
  1. 資料タイプ一覧
  2. 学術雑誌論文
  1. 鳥取大学の刊行物
  2. Yonago Acta Medica
  3. 44
  4. 2

Apoptotic Cell Death and p53 Expression in Leiomyosarcoma of Soft-Tissue Origin

https://repository.lib.tottori-u.ac.jp/records/5144
https://repository.lib.tottori-u.ac.jp/records/5144
4371eaf3-583a-464c-9132-716873e441da
名前 / ファイル ライセンス アクション
44_115-123.pdf 44_115-123.pdf (441.8 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-06-22
タイトル
タイトル Apoptotic Cell Death and p53 Expression in Leiomyosarcoma of Soft-Tissue Origin
言語 en
言語
言語 eng
キーワード
主題 apoptosis/immunohistochemistry/leiomyosarcoma/p53 protein
キーワード
言語 en
主題 apoptosis/immunohistochemistry/leiomyosarcoma/p53 protein
資源タイプ
資源タイプ journal article
著者 Yoshida, Haruhiko

× Yoshida, Haruhiko

WEKO 4502
e-Rad 40037429

Yoshida, Haruhiko

en Yoshida, Haruhiko

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Watanabe, Mari

× Watanabe, Mari

WEKO 19096

Watanabe, Mari

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Shomori, Kohei

× Shomori, Kohei

WEKO 3391
e-Rad 60314572

Shomori, Kohei

en Shomori, Kohei

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Ito, Hisao

× Ito, Hisao

WEKO 1103
e-Rad 60127610

Ito, Hisao

en Ito, Hisao

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Minamizaki, Takeshi

× Minamizaki, Takeshi

WEKO 19097

Minamizaki, Takeshi

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Watanabe, Mari

× Watanabe, Mari

WEKO 19098

en Watanabe, Mari

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Minamizaki, Takeshi

× Minamizaki, Takeshi

WEKO 19099

en Minamizaki, Takeshi

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著者所属
値 Department of Pathobiological Science and Technology, Tottori University Faculty of Medicine
著者所属
値 First Department of Pathology, Tottori University Faculty of Medicine
著者所属
値 First Department of Pathology, Tottori University Faculty of Medicine
著者所属
値 First Department of Pathology, Tottori University Faculty of Medicine
著者所属
値 Department of Orthopaedic Surgery, Tottori University Faculty of Medicine
抄録
内容記述タイプ Other
内容記述 Leiomyosarcoma (LMS) of soft-tissue origin was studied on the expression and the biological significance of apoptosis in relation to p53 oncoprotein. Immunohistochemical analysis was performed initially on the paraffin-embbeded sections taken from 29 surgical tissues (20 cases) including 9 recurrent/metastatic tumors. The results are as follows: A positive correlation was observed between the p53 indices (PIs) and the proliferative markers designated by Ki-67, PCNA and MCM2, both of which increased significantly in the high-grade malignant LMS much more than in the low-grade one (P < 0.001). Apoptotic cells were detected by the TUNEL method and evaluated as the apoptotic index (AI). A high AI-level was shown in the high-grade malignant LMS, especially in cases of the recurrent/metastatic sites in comparison with the tumors of the primary site (P < 0.05). The AI was statistically higher in the p53-positive cases of high-grade malignant LMS than in the p53-negative cases of low-grade malignant LMS. In conclusion, apoptotic activity paralleled the overexpression of p53 protein along with an increasing grade of malignancy and may be related intimately to the increased malignant potential, especially to recurrence/metastasis.
書誌情報 Yonago Acta medica
en : Yonago Acta medica

巻 44, 号 2, p. 115-123, 発行日 2001-07
出版者
出版者 Tottori University Faculty of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 13468049
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00892882
権利
権利情報 Yonago Acta medica 編集委員会
情報源
関連名称 Yonago Acta medica. 2001, 44(2), 115-123
著者版フラグ
出版タイプ VoR
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