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Association between Vitamin D Receptor Gene Polymorphisms and Renal Osteodystrophy in Patients on Maintenance Hemodialysis
https://repository.lib.tottori-u.ac.jp/records/5153
https://repository.lib.tottori-u.ac.jp/records/515360ad151c-4053-4885-98f2-b66fc09848b7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
43_027-038.pdf (186.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Association between Vitamin D Receptor Gene Polymorphisms and Renal Osteodystrophy in Patients on Maintenance Hemodialysis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | bone mineral density | |||||
| キーワード | ||||||
| 主題 | hemodialysis | |||||
| キーワード | ||||||
| 主題 | renal osteodystrophy | |||||
| キーワード | ||||||
| 主題 | vitamin D receptor gene polymorphismz | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | bone mineral density | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | hemodialysis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | renal osteodystrophy | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | vitamin D receptor gene polymorphismz | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Kohama, Kiyotaka
× Kohama, Kiyotaka× Uemasu, Jiro× Kawasaki, Hironaka× Nanba, Eiji× Tokumoto, Akihide× Kohama, Kiyotaka× Uemasu, Jiro× Kawasaki, Hironaka× Tokumoto, Akihide |
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| 著者所属 | ||||||
| 値 | Second Department of Internal Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Second Department of Internal Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Second Department of Internal Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Gene Research Center, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Division of Nephrology, Sanin Rosai Hospital | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | We examined the possible involvement of vitamin D receptor (VDR) gene polymorphisms in patients on maintenance hemodialysis and further investigated the relation between VDR genotypes and bone histology. Two hundred and nine patients undergoing regular hemodialysis (male/female ratio, 124/85) were included in this study. DNA was extracted from peripheral blood leukocytes. VDR genotypes were analyzed as restriction fragment length polymorphisms, by using BsmI, ApaI, TaqI and FokI. Lumbar bone mineral density was measured by dual-energy X-ray absorptiometry, and expressed as a Z-score. Serum 1,25(OH)2D3, osteocalcin and ntact-parathyroid hormone (i-PTH) were determined by an immunoradiometric assay. In 97 patients, bone biopsy as performed and the histology was divided into osteitis fibrosa, mild lesion, dynamic bone disease and osteomalacia. Serum levels of osteocalcin, i-PTH and bone mineral density were significantly lower in the presence of B, A, t and f alleles. However, in this study, we did not find any association between bone histology and the four VDR genotypes. We concluded that renal osteodystrophy in dialysis patients was modified by environmental factors such as medication with active vitamin D, age, gender and duration of chronic renal failure, and that the impact of the VDR allelic effect may play a small role in determining on bone histology. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 43, 号 1, p. 27-38, 発行日 2000-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2000, 43(1), 27-38 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
