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α-Fetoprotein Messenger RNA in the Blood Predicts Poor Prognosis of the Patients with Hepatocellular Carcinoma
https://repository.lib.tottori-u.ac.jp/records/5155
https://repository.lib.tottori-u.ac.jp/records/51559450030d-1b12-4379-a7fb-f3422c26dae3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
43_047-057.pdf (114.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | α-Fetoprotein Messenger RNA in the Blood Predicts Poor Prognosis of the Patients with Hepatocellular Carcinoma | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | α-fetoprotein messenger RNA | |||||
| キーワード | ||||||
| 主題 | hepatocellular carcinoma | |||||
| キーワード | ||||||
| 主題 | metastasis | |||||
| キーワード | ||||||
| 主題 | tumor marker | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | α-fetoprotein messenger RNA | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | hepatocellular carcinoma | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | metastasis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | tumor marker | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Kawakami, Manri
× Kawakami, Manri× Koda, Masahiko× Murawaki, Yoshikazu× Kawasaki, Hironaka× Ikawa, Shiro× Kawakami, Manri× Koda, Masahiko× Kawasaki, Hironaka× Ikawa, Shiro |
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| 著者所属 | ||||||
| 値 | Department of Clinical Laboratory Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Second Department of Internal Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Second Department of Internal Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Second Department of Internal Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Department of Clinical Laboratory Medicine, Faculty of Medicine, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | α-Fetoprotein (AFP) messenger RNA (mRNA) in the peripheral blood of patients with hepatocellular carcinoma (HCC) may indicate hematogenous spread of HCC. This study examined the presence of AFP mRNA in the blood of 148 patients, in terms of clinical parameters, tumor metastasis and survival rate. For the prospective study, 109 patients with HCC were followed in the period between March 1996 and March 1999. AFP mRNA in the blood was examined by means of nested reverse transcription polymerase chain reaction. AFP mRNA was detected in the blood in 23 (15.5%) of 148 patients with HCC. AFP mRNA in the blood was significantly correlated with protein induced by vitamin K absence or antagonist II level, higher AFP level (200 IU/mL or more) and extrahepatic metastases, but not with tumor size, number of tumor nodules or tumor-nodule-metastasis stage. This prospective study confirmed that intra- and extra-hepatic metastases developed more frequently in the 22 AFP mRNA-positive patients than in the 87 AFP mRNA-negative patients (P < 0.01). The cumulative survival rate was significantly lower in the former than in the latter (P < 0.01). In conclusion, AFP mRNA in the blood is closely related to hematogenous spread and might be a good predictor of metastasis and poorer survival rate in HCC patients. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 43, 号 1, p. 47-57, 発行日 2000-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2000, 43(1), 47-57 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
