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Expression of Surface Markers on Mature Monocyte-Derived Dendritic Cells from Allergic Asthmatics
https://repository.lib.tottori-u.ac.jp/records/5166
https://repository.lib.tottori-u.ac.jp/records/516649ec8ee0-09c8-49f8-8017-5204b7c3dbed
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-06-22 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Expression of Surface Markers on Mature Monocyte-Derived Dendritic Cells from Allergic Asthmatics | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | asthma | |||||
キーワード | ||||||
主題 | dendritic cells | |||||
キーワード | ||||||
主題 | histocompatibility leukocyte antigen-deoxyribose | |||||
キーワード | ||||||
主題 | house dust mite | |||||
キーワード | ||||||
主題 | mannose receptor | |||||
キーワード | ||||||
言語 | en | |||||
主題 | asthma | |||||
キーワード | ||||||
言語 | en | |||||
主題 | dendritic cells | |||||
キーワード | ||||||
言語 | en | |||||
主題 | histocompatibility leukocyte antigen-deoxyribose | |||||
キーワード | ||||||
言語 | en | |||||
主題 | house dust mite | |||||
キーワード | ||||||
言語 | en | |||||
主題 | mannose receptor | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
Yajima, Hiroki
× Yajima, Hiroki× Tomita, Katsuyuki× Hitsuda, Yutaka× Yajima, Hiroki× Tomita, Katsuyuki× Hitsuda, Yutaka |
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著者所属 | ||||||
Third Department of Internal Medicine, Faculty of Medicine, Tottori University | ||||||
著者所属 | ||||||
Third Department of Internal Medicine, Faculty of Medicine, Tottori University | ||||||
著者所属 | ||||||
Third Department of Internal Medicine, Faculty of Medicine, Tottori University | ||||||
抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Dendritic cells (DCs) are one type of important inflammatory cells in the pathogenesis of asthma for early response to allergen exposure. Monocyte-derived DCs (MoDCs) are characterized by a high antigen uptake capacity and poor T-cell stimulatory activity, both features of immature DCs. By stimulation with tumor necrosis factor-alpha (TNF-alpha) or antigen capture, these cells differentiate into mature DCs with the disappearance of antigen-capturing regions, and increase in stimulatory activity. We measured the expression of some molecules on MoDCs before and after stimulation with TNF-alpha or house dust mite (HDM) antigen, from 9 house dust mite (HDM)-allergic asthmatic patients and 8 normal control subjects by flow cytometry. Primary MoDCs from HDM-allergic asthmatics showed a greater expression of histocompatibility leukocyte antigen (HLA)-DR and mannose receptor (MR), but not of CD80, CD86 or intercellular adhesion molecule-1 (ICAM-1), than those from normal subjects (P < 0.05). After stimulation with TNF-alpha or HDM, DCs from asthmatic patients showed a greater expression of HLA-DR, CD86 and ICAM-1, than those from normal subjects. In HDM-allergic asthmatic patients, MR expression on DCs significantly declined after stimulation by HDM compared with stimulation by TNF-alpha (P < 0.05). Results suggest that the reduction of MR expression may be characteristic on mature DCs after HDM exposure in allergic asthma. | |||||
書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 42, 号 1, p. 1-10, 発行日 1999-03 |
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出版者 | ||||||
出版者 | Tottori University Faculty of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13468049 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00892882 | |||||
権利 | ||||||
権利情報 | Yonago Acta medica 編集委員会 | |||||
情報源 | ||||||
関連名称 | Yonago Acta medica. 1999, 42(1), 1-10 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |