{"_buckets": {"deposit": "3d8e92c6-6c5d-4b4a-97f2-abeb3b060435"}, "_deposit": {"created_by": 10, "id": "5166", "owners": [10], "pid": {"revision_id": 0, "type": "depid", "value": "5166"}, "status": "published"}, "_oai": {"id": "oai:repository.lib.tottori-u.ac.jp:00005166", "sets": ["12", "9", "1092"]}, "author_link": ["19194", "19195", "19196", "19197", "19198", "19199"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1999-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "10", "bibliographicPageStart": "1", "bibliographicVolumeNumber": "42", "bibliographic_titles": [{"bibliographic_title": "Yonago Acta medica"}, {"bibliographic_title": "Yonago Acta medica", "bibliographic_titleLang": "en"}]}]}, "item_10001_checkbox_27": {"attribute_name": "部局名", "attribute_value_mlt": [{"subitem_checkbox_item": ["i-gakubu"]}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Dendritic cells (DCs) are one type of important inflammatory cells in the pathogenesis of asthma for early response to allergen exposure. Monocyte-derived DCs (MoDCs) are characterized by a high antigen uptake capacity and poor T-cell stimulatory activity, both features of immature DCs. By stimulation with tumor necrosis factor-alpha (TNF-alpha) or antigen capture, these cells differentiate into mature DCs with the disappearance of antigen-capturing regions, and increase in stimulatory activity. We measured the expression of some molecules on MoDCs before and after stimulation with TNF-alpha or house dust mite (HDM) antigen, from 9 house dust mite (HDM)-allergic asthmatic patients and 8 normal control subjects by flow cytometry. Primary MoDCs from HDM-allergic asthmatics showed a greater expression of histocompatibility leukocyte antigen (HLA)-DR and mannose receptor (MR), but not of CD80, CD86 or intercellular adhesion molecule-1 (ICAM-1), than those from normal subjects (P \u003c 0.05). After stimulation with TNF-alpha or HDM, DCs from asthmatic patients showed a greater expression of HLA-DR, CD86 and ICAM-1, than those from normal subjects. In HDM-allergic asthmatic patients, MR expression on DCs significantly declined after stimulation by HDM compared with stimulation by TNF-alpha (P \u003c 0.05). Results suggest that the reduction of MR expression may be characteristic on mature DCs after HDM exposure in allergic asthma.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Tottori University Faculty of Medicine"}]}, "item_10001_relation_16": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "Yonago Acta medica. 1999, 42(1), 1-10"}]}]}, "item_10001_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Yonago Acta medica　編集委員会"}]}, "item_10001_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00892882", "subitem_source_identifier_type": "NCID"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "13468049", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_text_25": {"attribute_name": "EARMAS ID", "attribute_value_mlt": [{"subitem_text_value": "906"}]}, "item_10001_text_29": {"attribute_name": "最新掲載誌名", "attribute_value_mlt": [{"subitem_text_value": "yam;Yonago Acta medica;Yonago Acta medica"}]}, "item_10001_text_32": {"attribute_name": "著者所属", "attribute_value_mlt": [{"subitem_text_value": "Third Department of Internal Medicine, Faculty of Medicine, Tottori University"}, {"subitem_text_value": "Third Department of Internal Medicine, Faculty of Medicine, Tottori University"}, {"subitem_text_value": "Third Department of Internal Medicine, Faculty of Medicine, Tottori University"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yajima, Hiroki"}], "nameIdentifiers": [{"nameIdentifier": "19194", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tomita, Katsuyuki"}], "nameIdentifiers": [{"nameIdentifier": "19195", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hitsuda, Yutaka"}], "nameIdentifiers": [{"nameIdentifier": "19196", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yajima, Hiroki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "19197", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tomita, Katsuyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "19198", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hitsuda, Yutaka", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "19199", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2009-06-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "42_001-010.pdf", "filesize": [{"value": "70.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Yonago Acta medica　編集委員会", "licensetype": "license_note", "mimetype": "application/pdf", "size": 70900.0, "url": {"label": "42_001-010.pdf", "url": "https://repository.lib.tottori-u.ac.jp/record/5166/files/42_001-010.pdf"}, "version_id": "30a04f72-065e-458b-80bb-689ebcf5d9c7"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "asthma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "dendritic cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "histocompatibility leukocyte antigen-deoxyribose", "subitem_subject_scheme": "Other"}, {"subitem_subject": "house dust mite", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mannose receptor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "asthma", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "dendritic cells", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "histocompatibility leukocyte antigen-deoxyribose", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "house dust mite", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mannose receptor", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Expression of Surface Markers on Mature Monocyte-Derived Dendritic Cells from Allergic Asthmatics", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Expression of Surface Markers on Mature Monocyte-Derived Dendritic Cells from Allergic Asthmatics", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "10", "path": ["12", "9", "1092"], "permalink_uri": "https://repository.lib.tottori-u.ac.jp/records/5166", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2018-06-22"}, "publish_date": "2018-06-22", "publish_status": "0", "recid": "5166", "relation": {}, "relation_version_is_last": true, "title": ["Expression of Surface Markers on Mature Monocyte-Derived Dendritic Cells from Allergic Asthmatics"], "weko_shared_id": -1}