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Expression of Surface Markers on Mature Monocyte-Derived Dendritic Cells from Allergic Asthmatics
https://repository.lib.tottori-u.ac.jp/records/5166
https://repository.lib.tottori-u.ac.jp/records/516649ec8ee0-09c8-49f8-8017-5204b7c3dbed
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
42_001-010.pdf (70.9 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Expression of Surface Markers on Mature Monocyte-Derived Dendritic Cells from Allergic Asthmatics | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | asthma | |||||
| キーワード | ||||||
| 主題 | dendritic cells | |||||
| キーワード | ||||||
| 主題 | histocompatibility leukocyte antigen-deoxyribose | |||||
| キーワード | ||||||
| 主題 | house dust mite | |||||
| キーワード | ||||||
| 主題 | mannose receptor | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | asthma | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | dendritic cells | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | histocompatibility leukocyte antigen-deoxyribose | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | house dust mite | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | mannose receptor | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Yajima, Hiroki
× Yajima, Hiroki× Tomita, Katsuyuki× Hitsuda, Yutaka× Yajima, Hiroki× Tomita, Katsuyuki× Hitsuda, Yutaka |
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| 著者所属 | ||||||
| 値 | Third Department of Internal Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Third Department of Internal Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Third Department of Internal Medicine, Faculty of Medicine, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Dendritic cells (DCs) are one type of important inflammatory cells in the pathogenesis of asthma for early response to allergen exposure. Monocyte-derived DCs (MoDCs) are characterized by a high antigen uptake capacity and poor T-cell stimulatory activity, both features of immature DCs. By stimulation with tumor necrosis factor-alpha (TNF-alpha) or antigen capture, these cells differentiate into mature DCs with the disappearance of antigen-capturing regions, and increase in stimulatory activity. We measured the expression of some molecules on MoDCs before and after stimulation with TNF-alpha or house dust mite (HDM) antigen, from 9 house dust mite (HDM)-allergic asthmatic patients and 8 normal control subjects by flow cytometry. Primary MoDCs from HDM-allergic asthmatics showed a greater expression of histocompatibility leukocyte antigen (HLA)-DR and mannose receptor (MR), but not of CD80, CD86 or intercellular adhesion molecule-1 (ICAM-1), than those from normal subjects (P < 0.05). After stimulation with TNF-alpha or HDM, DCs from asthmatic patients showed a greater expression of HLA-DR, CD86 and ICAM-1, than those from normal subjects. In HDM-allergic asthmatic patients, MR expression on DCs significantly declined after stimulation by HDM compared with stimulation by TNF-alpha (P < 0.05). Results suggest that the reduction of MR expression may be characteristic on mature DCs after HDM exposure in allergic asthma. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 42, 号 1, p. 1-10, 発行日 1999-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 1999, 42(1), 1-10 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
