| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-06-22 |
| タイトル |
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|
タイトル |
Tyrosine Phosphorylation Regulates the Expression of Major Histocompatibility Complex Antigens on a Human Lung Cancer Cell Line by Interferon-gamma |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
human lung cancer |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
interferon-gamma |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
major histocompatibility complex |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
tyrosine phosphorylation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
human lung cancer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
interferon-gamma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
major histocompatibility complex |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
tyrosine phosphorylation |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
Suzuki, Yoshimasa
Tanaka, Yoshiyuki
Nakamura, Hiroshige
Ohgi, Shigetsugu
Tanaka, Yoshiyuki
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| 著者所属 |
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|
値 |
Second Department of Surgery, Faculty of Medicine, Tottori University |
| 著者所属 |
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|
値 |
Second Department of Surgery, Faculty of Medicine, Tottori University |
| 著者所属 |
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|
値 |
Second Department of Surgery, Faculty of Medicine, Tottori University |
| 著者所属 |
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|
値 |
Second Department of Surgery, Faculty of Medicine, Tottori University |
| 抄録 |
|
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内容記述タイプ |
Other |
|
内容記述 |
Expression of major histocompatibility complex (MHC) antigens on cancer cells is essential for cell-mediated immune function. However, these molecules are reduced on cancer cells enabling them to escape from host immune surveillance. It is well known that interferon-γ (IFN-γ) upregulates the expression of MHC molecules and restores the immunogenicity of cancer cells. Nevertheless, the mechanism by which IFN-γ modulates MHC expression on cancer cells is not clear. Therefore, in this report, we examined the role of tyrosine protein kinases in IFN-γ-induced MHC expression in a human lung adenocarcinoma cell line, HLC-1. We found that a tyrosine protein kinase inhibitor, herbimycin A, inhibited both IFN-γ-inducible MHC class I and class II expression, as assessed by flow cytometry. Additionally, assessment of tyrosine phosphorylation of cellular substrates by confocal laser microscopy using an anti-phosphotyrosine monoclonal antibody (mAb) revealed that IFN-γ induced protein tyrosine phosphorylation within 5 min of treatment. Herbimycin A inhibited this IFN-γ-induced tyrosine phosphorylation. Thus, tyrosine phosphorylation plays an important role in IFN-γ-induced MHC class I and class II expression on HLC-1 cells. |
| 書誌情報 |
Yonago Acta medica
en : Yonago Acta medica
巻 41,
号 1,
p. 1-6,
発行日 1998-03
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| 出版者 |
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|
出版者 |
Tottori University Faculty of Medicine |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13468049 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00892882 |
| 権利 |
|
|
権利情報 |
Yonago Acta medica 編集委員会 |
| 情報源 |
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|
関連名称 |
Yonago Acta medica. 1998, 41(1), 1-6 |
| 著者版フラグ |
|
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出版タイプ |
VoR |
41_001-006.pdf (271.0 kB)
