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Tyrosine Phosphorylation Regulates the Expression of Major Histocompatibility Complex Antigens on a Human Lung Cancer Cell Line by Interferon-gamma
https://repository.lib.tottori-u.ac.jp/records/5196
https://repository.lib.tottori-u.ac.jp/records/5196708a9fdf-a581-4228-8e64-18225b63da80
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
41_001-006.pdf (271.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2018-06-22 | |||||||||
| タイトル | ||||||||||
| タイトル | Tyrosine Phosphorylation Regulates the Expression of Major Histocompatibility Complex Antigens on a Human Lung Cancer Cell Line by Interferon-gamma | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | human lung cancer | |||||||||
| キーワード | ||||||||||
| 主題 | interferon-gamma | |||||||||
| キーワード | ||||||||||
| 主題 | major histocompatibility complex | |||||||||
| キーワード | ||||||||||
| 主題 | tyrosine phosphorylation | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題 | human lung cancer | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題 | interferon-gamma | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題 | major histocompatibility complex | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題 | tyrosine phosphorylation | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
Suzuki, Yoshimasa
× Suzuki, Yoshimasa× Tanaka, Yoshiyuki× Nakamura, Hiroshige
WEKO
2488
× Ohgi, Shigetsugu× Tanaka, Yoshiyuki |
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| 著者所属 | ||||||||||
| 値 | Second Department of Surgery, Faculty of Medicine, Tottori University | |||||||||
| 著者所属 | ||||||||||
| 値 | Second Department of Surgery, Faculty of Medicine, Tottori University | |||||||||
| 著者所属 | ||||||||||
| 値 | Second Department of Surgery, Faculty of Medicine, Tottori University | |||||||||
| 著者所属 | ||||||||||
| 値 | Second Department of Surgery, Faculty of Medicine, Tottori University | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Expression of major histocompatibility complex (MHC) antigens on cancer cells is essential for cell-mediated immune function. However, these molecules are reduced on cancer cells enabling them to escape from host immune surveillance. It is well known that interferon-γ (IFN-γ) upregulates the expression of MHC molecules and restores the immunogenicity of cancer cells. Nevertheless, the mechanism by which IFN-γ modulates MHC expression on cancer cells is not clear. Therefore, in this report, we examined the role of tyrosine protein kinases in IFN-γ-induced MHC expression in a human lung adenocarcinoma cell line, HLC-1. We found that a tyrosine protein kinase inhibitor, herbimycin A, inhibited both IFN-γ-inducible MHC class I and class II expression, as assessed by flow cytometry. Additionally, assessment of tyrosine phosphorylation of cellular substrates by confocal laser microscopy using an anti-phosphotyrosine monoclonal antibody (mAb) revealed that IFN-γ induced protein tyrosine phosphorylation within 5 min of treatment. Herbimycin A inhibited this IFN-γ-induced tyrosine phosphorylation. Thus, tyrosine phosphorylation plays an important role in IFN-γ-induced MHC class I and class II expression on HLC-1 cells. | |||||||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 41, 号 1, p. 1-6, 発行日 1998-03 |
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| 出版者 | ||||||||||
| 出版者 | Tottori University Faculty of Medicine | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 13468049 | |||||||||
| 書誌レコードID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA00892882 | |||||||||
| 権利 | ||||||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||||||
| 情報源 | ||||||||||
| 関連名称 | Yonago Acta medica. 1998, 41(1), 1-6 | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
