{"_buckets": {"deposit": "1a0ee95e-e3ad-414f-9d9e-fc737fd361d7"}, "_deposit": {"created_by": 1, "id": "5196", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "5196"}, "status": "published"}, "_oai": {"id": "oai:repository.lib.tottori-u.ac.jp:00005196", "sets": ["9", "12", "1096"]}, "author_link": ["3524", "2779", "2488", "19322", "19323"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1998-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "6", "bibliographicPageStart": "1", "bibliographicVolumeNumber": "41", "bibliographic_titles": [{"bibliographic_title": "Yonago Acta medica"}, {"bibliographic_title": "Yonago Acta medica", "bibliographic_titleLang": "en"}]}]}, "item_10001_checkbox_27": {"attribute_name": "部局名", "attribute_value_mlt": [{"subitem_checkbox_item": ["i-gakubu"]}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Expression of major histocompatibility complex (MHC) antigens on cancer cells is essential for cell-mediated immune function. However, these molecules are reduced on cancer cells enabling them to escape from host immune surveillance. It is well known that interferon-γ (IFN-γ) upregulates the expression of MHC molecules and restores the immunogenicity of cancer cells. Nevertheless, the mechanism by which IFN-γ modulates MHC expression on cancer cells is not clear. Therefore, in this report, we examined the role of tyrosine protein kinases in IFN-γ-induced MHC expression in a human lung adenocarcinoma cell line, HLC-1. We found that a tyrosine protein kinase inhibitor, herbimycin A, inhibited both IFN-γ-inducible MHC class I and class II expression, as assessed by flow cytometry. Additionally, assessment of tyrosine phosphorylation of cellular substrates by confocal laser microscopy using an anti-phosphotyrosine monoclonal antibody (mAb) revealed that IFN-γ induced protein tyrosine phosphorylation within 5 min of treatment. Herbimycin A inhibited this IFN-γ-induced tyrosine phosphorylation. Thus, tyrosine phosphorylation plays an important role in IFN-γ-induced MHC class I and class II expression on HLC-1 cells.", "subitem_description_type": "Abstract"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Tottori University Faculty of Medicine"}]}, "item_10001_relation_16": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "Yonago Acta medica. 1998, 41(1), 1-6"}]}]}, "item_10001_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Yonago Acta medica　編集委員会"}]}, "item_10001_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00892882", "subitem_source_identifier_type": "NCID"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "13468049", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_text_25": {"attribute_name": "EARMAS ID", "attribute_value_mlt": [{"subitem_text_value": "1071"}]}, "item_10001_text_29": {"attribute_name": "最新掲載誌名", "attribute_value_mlt": [{"subitem_text_value": "yam;Yonago Acta medica;Yonago Acta medica"}]}, "item_10001_text_32": {"attribute_name": "著者所属", "attribute_value_mlt": [{"subitem_text_value": "Second Department of Surgery, Faculty of Medicine, Tottori University"}, {"subitem_text_value": "Second Department of Surgery, Faculty of Medicine, Tottori University"}, {"subitem_text_value": "Second Department of Surgery, Faculty of Medicine, Tottori University"}, {"subitem_text_value": "Second Department of Surgery, Faculty of Medicine, Tottori University"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Suzuki, Yoshimasa"}, {"creatorName": "Suzuki, Yoshimasa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3524", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "00335514", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=00335514"}, {"nameIdentifier": "100001959", "nameIdentifierScheme": "研究者総覧鳥取大学", "nameIdentifierURI": "http://researchers.adm.tottori-u.ac.jp/html/100001959_ja.html"}]}, {"creatorNames": [{"creatorName": "Tanaka, Yoshiyuki"}], "nameIdentifiers": [{"nameIdentifier": "19322", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Hiroshige"}, {"creatorName": "Nakamura, Hiroshige", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "2488", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30252852", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30252852"}, {"nameIdentifier": "100000400", "nameIdentifierScheme": "研究者総覧鳥取大学", "nameIdentifierURI": "http://researchers.adm.tottori-u.ac.jp/html/100000400_ja.html"}]}, {"creatorNames": [{"creatorName": "Ohgi, Shigetsugu"}, {"creatorName": "Ohgi, Shigetsugu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "2779", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50168845", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50168845"}]}, {"creatorNames": [{"creatorName": "Tanaka, Yoshiyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "19323", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2009-06-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "41_001-006.pdf", "filesize": [{"value": "271.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Yonago Acta medica　編集委員会", "licensetype": "license_free", "mimetype": "application/pdf", "size": 271000.0, "url": {"label": "41_001-006.pdf", "url": "https://repository.lib.tottori-u.ac.jp/record/5196/files/41_001-006.pdf"}, "version_id": "cd5958f3-e558-4ead-b91f-33b3f99f9a8b"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "human lung cancer", "subitem_subject_scheme": "Other"}, {"subitem_subject": "interferon-gamma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "major histocompatibility complex", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tyrosine phosphorylation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "human lung cancer", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "interferon-gamma", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "major histocompatibility complex", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tyrosine phosphorylation", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Tyrosine Phosphorylation Regulates the Expression of Major Histocompatibility Complex Antigens on a Human Lung Cancer Cell Line by Interferon-gamma", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Tyrosine Phosphorylation Regulates the Expression of Major Histocompatibility Complex Antigens on a Human Lung Cancer Cell Line by Interferon-gamma", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "1", "path": ["9", "12", "1096"], "permalink_uri": "https://repository.lib.tottori-u.ac.jp/records/5196", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-06-22"}, "publish_date": "2018-06-22", "publish_status": "0", "recid": "5196", "relation": {}, "relation_version_is_last": true, "title": ["Tyrosine Phosphorylation Regulates the Expression of Major Histocompatibility Complex Antigens on a Human Lung Cancer Cell Line by Interferon-gamma"], "weko_shared_id": -1}