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Effect of a Nitric Oxide Donor on Intracellular Cytokine Production in Normal Human Peripheral Lymphocytes
https://repository.lib.tottori-u.ac.jp/records/5197
https://repository.lib.tottori-u.ac.jp/records/5197abcbabd4-c466-4301-b5a3-2966616e4d4c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
41_007-015.pdf (162.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Effect of a Nitric Oxide Donor on Intracellular Cytokine Production in Normal Human Peripheral Lymphocytes | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | IFN-γ | |||||
| キーワード | ||||||
| 主題 | IL-4 | |||||
| キーワード | ||||||
| 主題 | intracellular cytokines | |||||
| キーワード | ||||||
| 主題 | NO | |||||
| キーワード | ||||||
| 主題 | sodium nitroprusside | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | IFN-γ | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | IL-4 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | intracellular cytokines | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | NO | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | sodium nitroprusside | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Yamasaki, Akira
× Yamasaki, Akira× Tomita, Katsuyuki× Hitsuda, Yutaka× Tomita, Katsuyuki× Hitsuda, Yutaka |
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| 著者所属 | ||||||
| 値 | Third Department of Internal Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Third Department of Internal Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Third Department of Internal Medicine, Faculty of Medicine, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | It has been recently suggested that nitric oxide (NO) plays an important role in modulating immune responses including helper T (Th) cell differentiation. To investigate the effect of NO on cytokine production in T cells, we examined in vitro the percentage of interferon (IFN)-γ and interleukin (IL)-4 producing cells by the intracellular cytokine staining method with flow cytometry. The percentage of IFN-γ and IL-4 producing cells reached maximal value 8 h after stimulation by phorbol 12-myristate 13-acetate (PMA) and ionomycin. When an NO donor, sodium nitroprusside (SNP), was co-incubated with PMA and ionomycin for 8 h, nitrite levels increased in a dose dependent manner for SNP (P = 0.007; Friedman test). The percentage of IFN-γ producing cells was diminished in consequence of the increasing doses of SNP (P = 0.002; Friedman test). While the percentage of IL-4 producing cells tended to be diminished by SNP, this difference, however, was statistically not significant (P = 0.062; Friedman test). Therefore, we have suggested that NO might affect Th cell differentiation through inhibition of Th1-cytokine production and might cause a Th2 cell predominant state. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 41, 号 1, p. 7-15, 発行日 1998-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 1998, 41(1), 7-15 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
