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Phenotype Analysis and Quantification of Proliferating Cells in the Cortical Gray Matter of the Adult Rat
https://repository.lib.tottori-u.ac.jp/records/7086
https://repository.lib.tottori-u.ac.jp/records/7086b26c217b-2826-4177-8b38-f74a9ef750a9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ahc42(1)_1.pdf (1.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2020-01-22 | |||||
| タイトル | ||||||
| タイトル | Phenotype Analysis and Quantification of Proliferating Cells in the Cortical Gray Matter of the Adult Rat | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | NG2 | |||||
| キーワード | ||||||
| 主題 | adult brain | |||||
| キーワード | ||||||
| 主題 | precursor | |||||
| キーワード | ||||||
| 主題 | quantification | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | NG2 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | adult brain | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | precursor | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | quantification | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Mori, Tetsuji
× Mori, Tetsuji× Wakabayashi, Taketoshi× Takamori, Yasuharu× Kitaya, Kotaro× Yamada, Hisao |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy & Cell Science, Kansai Medical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy & Cell Science, Kansai Medical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy & Cell Science, Kansai Medical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy & Cell Science, Kansai Medical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy & Cell Science, Kansai Medical University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | In intact adult mammalian brains, there are two neurogenic regions: the subependymal zone and the subgranular layer of the hippocampus. Even outside these regions, small numbers of proliferating precursors do exist. Many studies suggest that the majority of these are oligodendrocyte precursors that express NG2, a chondroitin sulfate proteoglycan, and most of the residual proliferating cells seem to be endothelial cells. However, it is still unclear whether NG2-immunonegative proliferating precursors are present, because previous studies have neglected their possible existence. In this study, we systematically analyzed the phenotypes of the proliferating cells in the intact adult rat cortical gray matter. We improved our techniques and carefully characterized the proliferating cells, because there were several problems with identifying and quantifying the proliferating cells: the detection of NG2-expressing cells was dependent on the fixation condition; there were residual proliferating leukocytes in the blood vessels; and two anti-NG2 antibodies gave rise to different staining patterns. Moreover, we used two methods, BrdU and Ki67 immunostaining, to quantify the proliferating cells. Our results strongly suggest that in the intact adult cerebral cortical gray matter, there were only two types of proliferating cells: the majority were NG2-expressing cells, including pericytes, and the rest were endothelial cells. | |||||
| 書誌情報 |
Acta histochemica et cytochemica en : Acta histochemica et cytochemica 巻 42, 号 1, p. 1-8, 発行日 2009 |
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| 雑誌内区分 | ||||||
| 値 | REGULAR ARTICLE | |||||
| 出版者 | ||||||
| 出版者 | Japan Society of Histochemistry and Cytochemistry | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13475800 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA1202220X | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1267/ahc.08037 | |||||
| 権利 | ||||||
| 権利情報 | © 2009 By the Japan Society of Histochemistry and Cytochemistry. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original | |||||
| 情報源 | ||||||
| 関連名称 | Tetsuji Mori, Taketoshi Wakabayashi, Yasuharu Takamori, Kotaro Kitaya, Hisao Yamada. Phenotype Analysis and Quantification of Proliferating Cells in the Cortical Gray Matter of the Adult Rat. ACTA HISTOCHEMICA ET CYTOCHEMICA, 2009, Volume 42, Issue 1, Pag | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/ahc/42/1/42_08037/_article | |||||
| 関連名称 | https://www.jstage.jst.go.jp/article/ahc/42/1/42_08037/_article | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
