| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-12-15 |
| タイトル |
|
|
タイトル |
Cetuximab and paclitaxel combination therapy for recurrent basaloid squamous cell carcinoma in the ethmoid sinus |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Basaloid squamous cell carcinoma |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Cetuximab |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Head and neck |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Metastasis |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Chemotherapy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Basaloid squamous cell carcinoma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Cetuximab |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Head and neck |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Metastasis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Chemotherapy |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
小山, 哲史
藤原, 和典
中村, 陽祐
福原, 隆宏
竹内, 裕美
Morisaki, Tsuyoshi
Fujii, Taihei
|
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine / Center for Head and Neck Surgery, Kusatsu General Hospital |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Basaloid squamous cell carcinoma (BSCC), a histologically distinctive variant of squamous cell carcinoma comprising basal cell carcinoma and squamous cell carcinoma, is aggressive and shows a poor prognosis because of frequent lymph node invasion and distant metastases. To date few articles regarding chemotherapy for metastatic disease have been reported, thus feasible chemotherapy is not well established. Cetuximab is a monoclonal antibody for epithelial growth factor receptor (EGFR), which has great efficacy for head and neck squamous cell carcinoma due to EGFR signaling pathway blockage. Because BSCC also highly expresses EGFR, cetuximab may be effective for BSCC. We report here a first case of recurrent BSCC in the ethmoid sinus with intracranial extension treated with cetuximab-based chemotherapy, which revealed great response in a 40-year-old man. Positron emission tomography (PET) revealed no lymph node or distant metastasis. The patient underwent chemoradiotherapy 66 Gy in 33 fractions with triweekly 100 mg/m2 cisplatin. However, 12 weeks after treatment completion PET revealed a residual tumor at the primary cancer site. Combination therapy with weekly paclitaxel and cetuximab was started, and complete response was observed 2 months from treatment initiation. The patient has maintained complete response for 32 months, and no tumor regrowth has been observed. |
| 書誌情報 |
Auris Nasus Larynx
en : Auris Nasus Larynx
巻 48,
号 6,
p. 1189-1192,
発行日 2021-12
|
| 出版者 |
|
|
出版者 |
Elsevier B.V. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03858146 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.anl.2020.07.002 |
| 権利 |
|
|
権利情報 |
© 2020 Oto-Rhino-Laryngological Society of Japan Inc. Published by Elsevier B.V. All rights reserved. |
| 情報源 |
|
|
|
関連名称 |
Koyama, Satoshi. Fujiwara, Kazunori. Morisaki, Tsuyoshi. et al. Cetuximab and paclitaxel combination therapy for recurrent basaloid squamous cell carcinoma in the ethmoid sinus. Auris Nasus Larynx. 48(6), 1189-1192. 2020-07-16. |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.sciencedirect.com/science/article/pii/S0385814620301590 |
|
|
関連名称 |
https://www.sciencedirect.com/science/article/pii/S0385814620301590 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
anl48(6)_1189.pdf (482.8 kB)
